Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer حسب Kaizhao Hu (15670612)

"…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …"

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer حسب Kaizhao Hu (15670612)

"…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …"

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer حسب Kaizhao Hu (15670612)

"…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …"

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer حسب Kaizhao Hu (15670612)

"…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …"

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer حسب Kaizhao Hu (15670612)

"…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …"

Volcano plot on differential expression. حسب Bingshuo Shi (21485387)

"…The findings revealed that 5558 genes in total were significantly altered during diapause, with pyruvate kinase (PK), trehalose synthase (TPS), superoxide dismutase (SOD), citrate synthase (CS), and 20-hydroxyecdysone (20E) showing significant decreases. …"

Coverage of plant species in each plot. حسب Xuemei Xiang (20756894)

"…With the increase of warming and nitrogen deposition, the Shannon-Wiener index of plants increased first and then decreased. The plant functional richness index, functional diversity index, functional dispersion index, and Rao’s quadratic entropy index showed a decreasing trend. …"

Specifications and effects of heating devices. حسب Xuemei Xiang (20756894)

"…With the increase of warming and nitrogen deposition, the Shannon-Wiener index of plants increased first and then decreased. The plant functional richness index, functional diversity index, functional dispersion index, and Rao’s quadratic entropy index showed a decreasing trend. …"

Critical Role of Voltage Application Points in “Analog” and “Digital” Electrospray Ionization Mass Spectrometry حسب Min-Min Hung (21096009)

"…We also show that a single-polarity square AC waveform can be applied to the union or sample reservoir electrode, and if its frequency is sufficiently high, it has a similar effect as decreasing DC voltage, allowing for digital control of electrospray with square waves (by varying duty cycle). …"

Critical Role of Voltage Application Points in “Analog” and “Digital” Electrospray Ionization Mass Spectrometry حسب Min-Min Hung (21096009)

"…We also show that a single-polarity square AC waveform can be applied to the union or sample reservoir electrode, and if its frequency is sufficiently high, it has a similar effect as decreasing DC voltage, allowing for digital control of electrospray with square waves (by varying duty cycle). …"

Participant characteristics. حسب Ronald Kusolo (13200268)

"…Uganda conducted its first nationally representative NCD risk factor survey in 2014, and a second in 2023. We analyzed the prevalence of the common NCD risk factors to assess changes in these between 2014 and 2023. …"

Uganda 2023 NCD risk factor STEPS survey data. حسب Ronald Kusolo (13200268)

"…Uganda conducted its first nationally representative NCD risk factor survey in 2014, and a second in 2023. We analyzed the prevalence of the common NCD risk factors to assess changes in these between 2014 and 2023. …"

Uganda 2014 NCD risk factor STEPS survey data. حسب Ronald Kusolo (13200268)

"…Uganda conducted its first nationally representative NCD risk factor survey in 2014, and a second in 2023. We analyzed the prevalence of the common NCD risk factors to assess changes in these between 2014 and 2023. …"

The (A) logistic regression model (LRM) and (B) random forest model (RFM) with only conservation scores as independent variables (orange, yellow) show decreased model fitting metri... حسب Bushra Haque (20513785)

Photosynthetic efficiency (<i>Fv/Fm</i>) of (A) <i>Acropora</i> sp. and (B) <i>P. verrucosa</i> for the four groups. حسب Malte Ostendarp (13217973)

Refractive error, spectacle wear, and referrals among public and private school children based on the AAPOS 2021 referral criteria. حسب Zahi Wehbi (14863016)

الموضوعات:

Referral rate and rates of different refractive errors according to the different referral criteria. حسب Zahi Wehbi (14863016)

الموضوعات:

Demographics of all study participants (n = 308 students; 616 eyes). حسب Zahi Wehbi (14863016)

الموضوعات:

The sets of referral criteria applied in the study. حسب Zahi Wehbi (14863016)

الموضوعات:

BT9 exhibits a dose- and time-dependent cytotoxic effect on medulloblastoma. حسب Zahra Motahari (6814013)