Table 1_Organic fertilizer in combination with zeolite enhanced maize yield with lower greenhouse gas emissions in sandy loam soil in North China.docx by Xuexia Wang (3701098)

“…</p>Methods<p>In the present study, a 3-year maize field experiment was conducted on a sandy loam soil in the North China Plain with five treatments: no added fertilizer (control, CK), synthetic fertilizer (SF), organic fertilizer replacing 30% synthetic N fertilizer (OF), synthetic fertilizer with zeolite (ZSF), and organic fertilizer with zeolite (ZOF).…”

Table 1_Bacteroides ovatus-derived N-methylserotonin inhibit colorectal cancer via the HTR1D-mediated cAMP-PKA-NF-κB signaling axis.docx by Jikai He (11888466)

“…</p>Results<p>(1) CRC patients showed significantly increased metabolic pathways including glycolysis, methane metabolism, beneficial amino acid degradation, and linoleic acid degradation, along with significantly decreased B.o abundance and NMS levels, which were positively correlated; (2) NMS significantly inhibited CRC cell proliferation, migration, and invasion, while promoting apoptosis; (3) Combined treatment with B.o and orange fiber or NMS alone reduced tumorigenesis and improved intestinal barrier function; (4) Mechanistic studies revealed that these effects could be mediated through downregulation of 5-hydroxytryptamine receptor 1D (HTR1D) expression and inhibition of the cAMP/PKA/IκBα/NF-κB pathway; (5) The treatments optimized gut microbiota structure and metabolite composition.…”

Table 2_Bacteroides ovatus-derived N-methylserotonin inhibit colorectal cancer via the HTR1D-mediated cAMP-PKA-NF-κB signaling axis.xlsx by Jikai He (11888466)

“…</p>Results<p>(1) CRC patients showed significantly increased metabolic pathways including glycolysis, methane metabolism, beneficial amino acid degradation, and linoleic acid degradation, along with significantly decreased B.o abundance and NMS levels, which were positively correlated; (2) NMS significantly inhibited CRC cell proliferation, migration, and invasion, while promoting apoptosis; (3) Combined treatment with B.o and orange fiber or NMS alone reduced tumorigenesis and improved intestinal barrier function; (4) Mechanistic studies revealed that these effects could be mediated through downregulation of 5-hydroxytryptamine receptor 1D (HTR1D) expression and inhibition of the cAMP/PKA/IκBα/NF-κB pathway; (5) The treatments optimized gut microbiota structure and metabolite composition.…”

Exogenous jasmonic acid alleviates Cu-induced damages in guinea grass by enhancing photosynthesis, antioxidant enzyme activity and modifying associated metabolites by Jian Ren (175424)

“…The results indicated that Cu stress significantly reduced superoxide dismutase (−51.2%) and peroxidase (−38.0%), chlorophyll content, net photosynthetic rate (<i>Pn</i>), and led to decreases in leaf length, width, plant height, and biomass (−49.7%). …”

Data Sheet 1_Characterization of peripheral immune cells in kidney transplantation recipients under different immunosuppressive treatments.docx by Yunze Tai (21522872)

“…</p>Results<p>In KTRs, the expression of G-MDSCs and M-MDSCs was significantly higher than the HCs, while the expression of HLA-DR⁺ monocytes, CD38⁺/CD28⁺ activated T cells, CD4⁺ naïve T cells, CD4⁺ effector memory T cells, and central memory T cells were significantly lower. …”

HSP47 inhibitor Col003 may attenuates neurological impairment in chronic ischemic stroke rats by inhibiting LCN2 by Kejian Zhou (22557101)

“…</p> <p>Fourteen days post-MCAO, Col003 treatment significantly decreased cerebral infarct volume and enhanced neurological function scores in rats. …”

<i>Irresistible</i>^<i>p173</i> is an allele of the Cadherin-encoding gene <i>cdh16.</i> by Susannah S. Schloss (21238775)

“…<p><b>(A)</b> Conceptual translation of <i>cdh16</i> and the predicted consequences of the <i>irresistible</i>^<i>p173</i><i>,</i> and <i>cdh16</i>^<i>co79</i> mutations. …”

Data Sheet 1_Supplementary far-red light enhances the quality and root development of double-root-cutting grafted watermelon seedlings.docx by Cuinan Wu (650400)

“…The findings from this study present a practical method to enhance the quality of grafted watermelon seedlings.…”

<i>Edwardsiella piscicida</i> employs C3 derivative to mediate internalization and infection via the teleost-specific receptor by Mo-Fei Li (21624535)

“…When PoCD18 was knocked down or blocked, bacterial infection and tissue lesions were significantly decreased. Mechanistically, the intracellular domain of PoCD18 subsequently interacted with PoCytohesin and triggered the phosphorylation of the phosphatidylinositol 3-kinase (PI3K)/serine-threonine protein kinase (Akt) signalling pathway. …”

Tilmicosin inhibits the infections of currently prevalent porcine reproductive and respiratory syndrome viruses via the downregulation of CD163 expression by Ming Qiu (762714)

“…<p>Porcine reproductive and respiratory syndrome virus (PRRSV) has a disastrous impact on the global swine industry. …”

Data Sheet 1_Chito-oligosaccharide composites enhanced the adaptability of cotton seedlings to salinized soil by modulating photosynthetic efficiency and metabolite.doc by Mengjie An (9501175)

“…The results showed that salt stress reduced the contents of K⁺ and Ca²⁺ and enhanced the content of Na⁺ in cotton leaves compared to the control, which inhibited leaf photosynthesis and seedling growth. COS-PA application decreased leaf Na⁺ content significantly in salt-stressed cotton seedlings by 69.70%, and increased the leaf Ca²⁺ content, fresh weight of each plant part, transpiration rate, leaf chlorophyll concentration (Chl a), actual quantum yield, as well as stomatal conductance by 7.22%, 46.33%-96.36%, 96.65%, 44.53%, 27.15%, and 168.24%, respectively, compared with the no COS-PA application treatment. …”

Table 1_Integrative multiomics analysis reveals association of gut microbiota and its metabolites with susceptibility to keloids.xls by Dang Li (16400478)

“…<p>Keloid scarring is a fibroproliferative disease of the skin, which can significantly impact one’s quality of life through cosmetic concerns, physical discomfort (itchy; painful), restricted movement, and psychological distress. …”

Table_2_ATG5 and ATG7 Expression Levels Are Reduced in Cutaneous Melanoma and Regulated by NRF1.docx by Živa Frangež (5946392)

“…<p>Autophagy is a highly conserved cellular process in which intracellular proteins and organelles are sequestered and degraded after the fusion of double-membrane vesicles known as autophagosomes with lysosomes. …”

Image 13_Integrative multiomics analysis reveals association of gut microbiota and its metabolites with susceptibility to keloids.jpeg by Dang Li (16400478)

“…<p>Keloid scarring is a fibroproliferative disease of the skin, which can significantly impact one’s quality of life through cosmetic concerns, physical discomfort (itchy; painful), restricted movement, and psychological distress. …”

Image 1_Resveratrol and β-hydroxy-β-methylbutyric acid supplementation promotes ileal development and digestive function by altering microbial community abundance and metabolites i... by Jiacheng Gan (20413847)

“…These findings may provides a novel reference for the nutritional regulation to improve the production of Tibetan sheep.…”

Image 1_Integrative multiomics analysis reveals association of gut microbiota and its metabolites with susceptibility to keloids.jpeg by Dang Li (16400478)

“…<p>Keloid scarring is a fibroproliferative disease of the skin, which can significantly impact one’s quality of life through cosmetic concerns, physical discomfort (itchy; painful), restricted movement, and psychological distress. …”

Data Sheet 1_Anti-colorectal cancer effect of total minor ginsenosides produced by lactobacilli transformation of major ginsenosides by inducing apoptosis and regulating gut microb... by Yunjiao Shen (20524133)

“…</p>Materials and Methods<p>We employed the Cell Counting Kit-8 (CCK-8), TdT-mediated dUTP nick end labeling (TUNEL), and Western blot analysis in vitro to explore the anti-proliferative and pro-apoptotic functions of TMG in CT26.WT cells. In vivo, a xenograft model was established by subcutaneously injecting mice with CT26.WT cells and administering a dose of 100 mg/kg/day TMG to the tumor-bearing mice. …”

Alteration of Ubiquitination in the Brain of ENOPH1 Knockout Mice after Early Ischemic Stroke by Yike Wu (20982007)

“…Hence, the present study explored changes in the ubiquitinomic in early ischemic brain tissues between wildtype and ENOPH1 knockout mice using a comprehensive quantitative analysis. Our results showed that 4000 ubiquitination-modified sites in 1613 proteins were quantified, with 772 ubiquitinated sites in 464 proteins significantly decreasing or increasing after ENOPH1 knockout (fold change >1.5 or <1/1.5, <i>p</i> < 0.05). …”

Image 3_Gallic acid attenuates diabetic cardiomyopathy by inhibiting ferroptosis and protecting mitochondria via the TSPO/FTMT pathway.jpeg by Chenchao Zou (22768010)

“…Purpose<p>Diabetic cardiomyopathy (DCM), which is diabetes mellitus-induced cardiomyopathy, significantly elevates the risk of heart failure and sudden cardiac death. …”

Image 12_Integrative multiomics analysis reveals association of gut microbiota and its metabolites with susceptibility to keloids.jpeg by Dang Li (16400478)

“…<p>Keloid scarring is a fibroproliferative disease of the skin, which can significantly impact one’s quality of life through cosmetic concerns, physical discomfort (itchy; painful), restricted movement, and psychological distress. …”