Table 1_Burden of pulmonary arterial hypertension in children globally, regionally, and nationally (1990–2021): results from the global burden of disease study.docx by Lili Deng (152262)

“…Significantly, reductions were observed in both mortality and disability-adjusted life years (DALYs) associated with pediatric PAH, with mortality decreasing by 57.66% and DALYs by 63.59% over the study period, indicating progress in mitigating the disease burden. …”

Table 1_Genome-wide analysis of lncRNA in wheat (Triticum aestivum) and functional characterization of TalncR9 in response to drought stress.xlsx by Lianzhe Wang (6202643)

“…<p>Long noncoding RNAs (lncRNAs) play essential roles in a variety of biological processes in plants. While many lncRNAs have been identified, their functional roles in wheat (Triticum aestivum) remain largely unknown. …”

Data Sheet 1_Potential cerebrospinal fluid metabolomic biomarkers and early prediction model for Parkinson’s disease.docx by Yifan Zhang (119570)

“…A bidirectional causal relationship exists between genetically determined PD susceptibility and metabolites.…”

Table 5_Burden of pulmonary arterial hypertension in children globally, regionally, and nationally (1990–2021): results from the global burden of disease study.docx by Lili Deng (152262)

“…Significantly, reductions were observed in both mortality and disability-adjusted life years (DALYs) associated with pediatric PAH, with mortality decreasing by 57.66% and DALYs by 63.59% over the study period, indicating progress in mitigating the disease burden. …”

<b>Human Milk Oligosaccharides Mitigate Infant </b><b>Diarrhea</b><b> </b><b>and </b><b>Anxiety</b><b>-like </b><b>Behaviors</b><b> via Gut Microbiota Modulation in an EPEC O127 In... by wang wenxiu (21257327)

“…The results showed that HMOs significantly alleviated diarrhea symptoms, mitigated anxiety-like behaviors, reduced colon inflammation, and <a href="" target="_blank">restored gut barrier integrity</a>. …”

DataSheet1_Type I-conventional dendritic cells support the progression of multiple myeloma in the bone marrow.docx by Sayaka Suzuki (248729)

“…Consequently, the frequencies of exhausted CD8 T cells and regulatory T cells significantly decreased in the bone marrow of cDC1-depleted mice.…”

Data Sheet 1_Dynamic brain network reconfiguration following rTMS in males with cocaine use disorder.pdf by Chengjie Le (22099766)

“…Although FPCN-state self-transition decreased significantly following stimulation, it was not directly linked to craving improvement, indicating a potentially supportive but nonspecific role in perceptual recalibration. …”

Table1_Rethinking the prognosis model of differentiated thyroid carcinoma.docx by Liang He (305820)

“…More patients were classified as stage I, and the number of stage IV patients decreased significantly. The new system had a higher proportion of variance explained (PVE) (5.04%) and lower Akaike information criterion (AIC) (18,331.906) than the 8th TNM staging system (a PVE of 4.11% and AIC of 18,692.282). …”

Ameliorative impact of Juniperus Macrocarpa extract on methotrexate-induced hepatic damage in rats by Shahad Hassan Hadi (20141025)

“…Rats in groups 3 and 4 were given daily dosages of 100 mg and 200 mg of Juniperus macrocarpa aqueous extract, respectively, for two weeks before receiving a single intraperitoneal MTX injection. Juniperus macrocarpa extracts at both low and high doses substantially alleviated the MTX-provoked biochemical alterations, as evidenced by decreased levels of inflammatory parameters including TNF-α and IL-6 and hepatic enzymes including ALT, AST, and ALP. …”

Data Sheet 1_Cordycepin attenuates NLRP3/Caspase-1/GSDMD-mediated LPS-induced macrophage pyroptosis.pdf by Zige Liu (20724752)

“…Cordycepin pre-treatment significantly reduced ROS levels and XO activity, inhibited the expression of NLRP3, cleaved-Caspase-1, and cleaved-GSDMD, and decreased pyroptosis-associated inflammatory cytokines IL-1β and IL-18, along with Caspase-1 activity. …”

3-D burrow morphology of <i>Chondrites targionii</i> (Brongniart, 1828) from an Upper Jurassic firmground of Southern Germany by Franz-Josef Scharfenberg (13134765)

“…With intermediate effect size, statistically compared branch widths revealed significantly decreasing widths from unbranched tunnels over root branches to their side branches, which, along with the scale-leaf-shaped structures, may indicate a vermiform tracemaker. …”

Vitreous Olink Proteomics Uncovers Novel Inflammatory Proteins in Patients with Proliferative Diabetic Retinopathy by Jiayu Zhang (128702)

“…Key findings revealed 22 differentially expressed proteins (DEPs) when comparing the PDR and IMH groups, with 21 proteins showing increased expression and only one demonstrating decreased levels. Among these DEPs, fibroblast growth factor 23 (FGF23) emerged as a particularly promising candidate, as elevated expression was observed in retinal tissue from both diabetic (db/db) mice and the high-glucose (HG) or glyoxal-treated Müller glia (MG) cultures. …”

Data Sheet 1_BMP9 induces postnatal zonal stratification of immature articular cartilage through reconfiguration of the existing collagen framework.pdf by Miles Anderson-Watters (20626604)

“…In explants exposed to BMP9, collagen fibrils underwent angular displacement from 19° to 78° with respect to the surface, cell density decreased 1.77-fold, and chondrons were significantly larger. …”

Supplementary file 1_Cistanche tubulosa glycosides ameliorate cognitive decline in APP/PS1 mice via modulation of gut microbiota and fatty acid metabolism: insights from multi-omic... by Rui Hou (161624)

“…</p>Results<p>GCT treatment significantly improved spatial memory and reduced the protein levels of Aβ and proinflammatory factors in APP/PS1 mice. …”

Supplementary Material for: From childhood to adolescence: Long-term trends in severe obesity in German youth (2002–2023) by figshare admin karger (2628495)

“…Results Pre-pandemic, SO remained stable or declined in children under 12 until 2010: OR5: 0.8-1, p<0.001) but rose significantly afterward (OR5: 1.1-1.2, p<0.001). Children between 12-16 years of age showed a continuous increase, especially boys (boys12-16: OR5: 1.3, girls12-16: OR5: 1.1, p<0.001). …”

Data Sheet 1_Personalized temporal interference stimulation targeting striatum reduces functional stability and dynamic connectivity variability in the sensorimotor network.docx by Dongsheng Tang (5526149)

“…</p>Results<p>(1) Functional stability: TI stimulation significantly decreased functional stability in bilateral SMA regions (predominantly SMA proper, with parts of pre-SMA) compared to Sham and baseline conditions (P < 0.01). (2) Dynamic functional connectivity: TI stimulation reduced dFC variability between the right striatum and left SMA region (predominantly SMA proper, with parts of pre-SMA) compared to baseline (P < 0.01). (3) Safety: No adverse cognitive effects or side effects were observed, with good blinding effectiveness maintained throughout the study.…”

<b>Targeted Inhibition of Tumor-Intrinsic SIRPα Improve anti-PD-1 Resistance by Enhancing T Cell Immunity and Inhibits</b><b> Tumor </b><b>Proliferation in Esophageal Cancer: Thera... by Xi-Yang Tang (13184496)

“…Apoptosis of PBMC and Jurkat T cell were significantly decreased cocultured with SIRPA knockdown esophageal cells. …”

Data Sheet 1_Prepandemic levels of cytokines and immunoglobulins and risk of SARS-CoV-2 infection and COVID-19 in the general population of Barcelona.docx by Miquel Porta (199379)

“…</p>Results<p>Higher concentrations in 2016–17 of IL-8 and TNF-α significantly decreased the risk of SARS-CoV-2 seropositivity in 2020–21, whereas higher concentrations of MIP-1α were a risk factor for seropositivity. …”

Data Sheet 1_Suppressed intestinal secondary bile acids in moxifloxacin-induced hyperglycemia: studies in normal and diabetic GK rats.docx by Yewen Sun (8334138)

“…Gut microbiota associated with SBAs metabolism were significantly reduced, leading to decreased intestinal deoxycholic acid (DCA) and lithocholic acid (LCA). …”

Table 1_Exploring the alleviating effects of Bifidobacterium metabolite lactic acid on non-alcoholic steatohepatitis through the gut-liver axis.docx by Hongmei Zhao (250090)

“…</p>Results<p>In vivo findings indicated that, in comparison to CBX group (Control group without antibiotic treatment), NAFLD/CBX group (NAFLD group without antibiotic administration) and NAFLD/ABX group (NAFLD group with antibiotic administration) exhibited increased liver-to-body weight ratio, higher lipid droplet accumulation, aggravated liver histopathological damage, and elevated levels of AST (Aspartate Aminotransferase), ALT (Alanine Aminotransferase), TC (Total Cholesterol), TG (Triglycerides), LDL-C (Low-Density Lipoprotein Cholesterol), IL-6 (Interleukin-6), TNF-α (Tumor Necrosis Factor-alpha), IL-1β (Interleukin-1 beta), and NLRP3-related molecules, while HDL-C (High-Density Lipoprotein Cholesterol) levels significantly decreased. Intervention with Bifidobacterium significantly reversed these adverse changes. …”