Additional file 1 of MDM2-amplified esophageal adenocarcinomas exhibit an activated metabolic and immunosuppressive phenotype with multiple potential therapeutic targets by Karl Knipper (15016346)

“…Volcano plot of all detected proteins comparing the proteome of neoadjuvantly treated MDM2-amplified and non-amplified tumors. Grey: not significantly different expressed, blue: significantly decreased expression in neoadjuvantly treated MDM2-amplified tumors, red: significantly increased expression in neoadjuvantly treated MDM2-amplified tumors. …”

<b>Targeted Inhibition of Tumor-Intrinsic SIRPα Improve anti-PD-1 Resistance by Enhancing T Cell Immunity and Inhibits</b><b> Tumor </b><b>Proliferation in Esophageal Cancer: Thera... by Xi-Yang Tang (13184496)

“…Apoptosis of PBMC and Jurkat T cell were significantly decreased cocultured with SIRPA knockdown esophageal cells. …”

Data Sheet 1_α-Mangostin prevents diabetic cardiomyopathy by inhibiting oxidative damage and lipotoxicity through the AKT–FOXO1–CD36 pathway.pdf by Xue Bai (129175)

“…Oxidative stress and lipid metabolism disorder-induced myocardial cell damage are part of the pathogenesis of DCM. In this study, we investigated the effects of alpha-mangostin (A-MG), a natural antioxidant extracted from mangosteen peel, on in vitro and in vivo DCM models.…”

P4HA3 deficiency increased sensitization to immune checkpoint inhibitors and P4HA3 could predict the clinical therapeutic effect of PD-1 inhibitor (Camrelizumab). by Hong Yan Huang (20135965)

“…P4HA3 and Ki-67 were decreased in the knockdown groups by siRNA compared to the NC group. …”

The Effect of Chronic Stress on Apoptosis Regulation and Oncogenesis Evolution: A Theoretical Approach. by DIMITRIOS KIMOGLOU (20499350)

“…<br>Chronic stress disrupts the apoptotic process and contributes to<br>tumorigenesis. In particular, we seek to illustrate the epigenetic influence of stress on genes that control apoptosis, as well as the significance of the HPA axis as a therapeutic target for restoring cellular equilibrium. …”

Data Sheet 1_Effects of different fermentation temperatures on microbiomes of cigar tobacco leaves.pdf by Yun Jia (1583794)

“…Introduction<p>Microbiomes of cigar tobacco leaves play a pivotal role during the fermentation, and fermentation temperature is a key factor in shaping the structure and function of the microbial community. …”

A Proposal for Implementation of Multi-Factor Authentication (MFA) System for Enhanced Security By Stephen Mikah Makoshi by Stephen Mikah Makoshi (20998469)

“…<b>Reduced Reliance on Passwords</b>: Decreased risk of security incidents related to passwords.…”

<b>Nonlinear and Sex-Specific Associations of Vitamin D Metabolites with Inflammatory Blood Markers in 455,000 Adults</b> by XIN CHEN (10031207)

“…Lymphocytes: Inverse relationship with 25(OH)D (p < 0.001), and an inverse U-shaped relationship with 1,25(OH)₂D, peaking at ~90 pmol/L, with counts decreasing at both lower and higher levels (p < 0.001). …”

<b>Nonlinear and Sex-Specific Associations of Vitamin D Metabolites with Inflammatory Blood Markers in 455,000 Adults</b>Item by XIN CHEN (10031207)

“…Lymphocytes: Inverse relationship with 25(OH)D (p < 0.001), and an inverse U-shaped relationship with 1,25(OH)₂D, peaking at ~90 pmol/L, with counts decreasing at both lower and higher levels (p < 0.001). …”

Data Sheet 1_Dynamics of soil nutrients and biological activities along an infection chronosequence of pine wilt disease in subtropical Masson pine forests.docx by Xueyu Song (3600464)

“…The soil physicochemical properties, biological activities all decreased as soil depth increased. Redundancy analysis and Mantel tests underscored the critical role of Total potassium, pH, Total phosphorous, and bulk density in shaping microbial activities. …”

Data Sheet 4_Regulatory mechanisms of simulated precipitation on cbbL carbon-fixing microbial communities in the alpine source wetland.pdf by Ni Zhang (503928)

“…Chlorophyta exhibited an “n”-shaped variation pattern (P < 0.05). Soil carbon and nitrogen were the most important factors influencing the cbbL carbon-fixing microbial community in the source wetland, with their concentrations decreasing as precipitation increased. …”

Data Sheet 2_Regulatory mechanisms of simulated precipitation on cbbL carbon-fixing microbial communities in the alpine source wetland.pdf by Ni Zhang (503928)

“…Chlorophyta exhibited an “n”-shaped variation pattern (P < 0.05). Soil carbon and nitrogen were the most important factors influencing the cbbL carbon-fixing microbial community in the source wetland, with their concentrations decreasing as precipitation increased. …”

Data Sheet 3_Regulatory mechanisms of simulated precipitation on cbbL carbon-fixing microbial communities in the alpine source wetland.pdf by Ni Zhang (503928)

“…Chlorophyta exhibited an “n”-shaped variation pattern (P < 0.05). Soil carbon and nitrogen were the most important factors influencing the cbbL carbon-fixing microbial community in the source wetland, with their concentrations decreasing as precipitation increased. …”

Data Sheet 1_Regulatory mechanisms of simulated precipitation on cbbL carbon-fixing microbial communities in the alpine source wetland.pdf by Ni Zhang (503928)

“…Chlorophyta exhibited an “n”-shaped variation pattern (P < 0.05). Soil carbon and nitrogen were the most important factors influencing the cbbL carbon-fixing microbial community in the source wetland, with their concentrations decreasing as precipitation increased. …”

Data Sheet 5_Regulatory mechanisms of simulated precipitation on cbbL carbon-fixing microbial communities in the alpine source wetland.pdf by Ni Zhang (503928)

“…Chlorophyta exhibited an “n”-shaped variation pattern (P < 0.05). Soil carbon and nitrogen were the most important factors influencing the cbbL carbon-fixing microbial community in the source wetland, with their concentrations decreasing as precipitation increased. …”

data.xlsx by Juanjuan cui (22072841)

“…Our study also showed that foliar phosphorus, soil total phosphorus (TP), and microbial biomass phosphorus (MBP) decreased significantly from the growth phase to the stable phase, indicating potentialTP loss In addition, correlation analysis showed complex interactions between plants, soils, and microorganisms. …”

3-D burrow morphology of <i>Chondrites targionii</i> (Brongniart, 1828) from an Upper Jurassic firmground of Southern Germany by Franz-Josef Scharfenberg (13134765)

“…With intermediate effect size, statistically compared branch widths revealed significantly decreasing widths from unbranched tunnels over root branches to their side branches, which, along with the scale-leaf-shaped structures, may indicate a vermiform tracemaker. …”

Table 1_Dynamic evolution and influencing factors of green total factor productivity in the Yangtze River Economic Belt: a study based on the three-stage SBM-ML index model.xlsx by Fei Chen (13690)

“…The study revealed that (1) GTFP exhibits notable spatial disparities among the upper, middle, and lower reaches of the YREB, with the downstream areas showing higher levels than the upstream and midstream areas do. (2) After excluding environmental factors and random errors, the true GTFP level significantly decreases, indicating a notable environmental masking effect, with a masking effect of up to 63.9%. (3) The spatial distribution of GTFP overall shows a “low-high-low-high” pattern from west to east, forming an “N”-shaped spatial pattern. (4) The Tobit model regression results show that government governance enhances GTFP, while economic growth and intergovernmental fiscal decentralization hinder real GTFP. …”

DataSheet2_Fibroblasts modulate epithelial cell behavior within the proliferative niche and differentiated cell zone within a human colonic crypt model.xlsx by Angelo Massaro (11939127)

“…Bulk-RNA sequencing revealed 41 genes that were significantly upregulated and 190 genes that were significantly downregulated in cocultured epithelium relative to epithelium cultured without fibroblasts. …”

DataSheet1_Fibroblasts modulate epithelial cell behavior within the proliferative niche and differentiated cell zone within a human colonic crypt model.docx by Angelo Massaro (11939127)

“…Bulk-RNA sequencing revealed 41 genes that were significantly upregulated and 190 genes that were significantly downregulated in cocultured epithelium relative to epithelium cultured without fibroblasts. …”