Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Effect of <i>BgILP8</i> RNAi on secretory cell length and protein in <i>Blattella germanica.</i> by Viviana Pagone (22086362)

Basic parameters of backfill material. by Lei Zhu (16642)

“…The results indicate that: (1) The manifestation of mining pressure in gangue backfill mining is influenced by factors such as mining height and backfill collapse ratio; (2) Under the support of coal gangue, the concentrated stress in the coal seam significantly decreases, forming an arched shape according to the mining stages; (3) The range of plastic failure in the coal seam remains relatively stable under gangue backfill mining, with the plastic zone of the roof plate exhibiting a strip-like distribution; (4) Both range analysis and variance analysis revealed that the sensitivity ranking is backfill collapse ratio > mining height > elastic modulus. …”

Analysis data. by Lei Zhu (16642)

“…The results indicate that: (1) The manifestation of mining pressure in gangue backfill mining is influenced by factors such as mining height and backfill collapse ratio; (2) Under the support of coal gangue, the concentrated stress in the coal seam significantly decreases, forming an arched shape according to the mining stages; (3) The range of plastic failure in the coal seam remains relatively stable under gangue backfill mining, with the plastic zone of the roof plate exhibiting a strip-like distribution; (4) Both range analysis and variance analysis revealed that the sensitivity ranking is backfill collapse ratio > mining height > elastic modulus. …”

Basic mechanical parameters of rocks. by Lei Zhu (16642)

“…The results indicate that: (1) The manifestation of mining pressure in gangue backfill mining is influenced by factors such as mining height and backfill collapse ratio; (2) Under the support of coal gangue, the concentrated stress in the coal seam significantly decreases, forming an arched shape according to the mining stages; (3) The range of plastic failure in the coal seam remains relatively stable under gangue backfill mining, with the plastic zone of the roof plate exhibiting a strip-like distribution; (4) Both range analysis and variance analysis revealed that the sensitivity ranking is backfill collapse ratio > mining height > elastic modulus. …”

Range analysis data. by Lei Zhu (16642)

“…The results indicate that: (1) The manifestation of mining pressure in gangue backfill mining is influenced by factors such as mining height and backfill collapse ratio; (2) Under the support of coal gangue, the concentrated stress in the coal seam significantly decreases, forming an arched shape according to the mining stages; (3) The range of plastic failure in the coal seam remains relatively stable under gangue backfill mining, with the plastic zone of the roof plate exhibiting a strip-like distribution; (4) Both range analysis and variance analysis revealed that the sensitivity ranking is backfill collapse ratio > mining height > elastic modulus. …”

Peak stress of orthogonal experimental group. by Lei Zhu (16642)

“…The results indicate that: (1) The manifestation of mining pressure in gangue backfill mining is influenced by factors such as mining height and backfill collapse ratio; (2) Under the support of coal gangue, the concentrated stress in the coal seam significantly decreases, forming an arched shape according to the mining stages; (3) The range of plastic failure in the coal seam remains relatively stable under gangue backfill mining, with the plastic zone of the roof plate exhibiting a strip-like distribution; (4) Both range analysis and variance analysis revealed that the sensitivity ranking is backfill collapse ratio > mining height > elastic modulus. …”

Orthogonal test results diagram. by Lei Zhu (16642)

“…The results indicate that: (1) The manifestation of mining pressure in gangue backfill mining is influenced by factors such as mining height and backfill collapse ratio; (2) Under the support of coal gangue, the concentrated stress in the coal seam significantly decreases, forming an arched shape according to the mining stages; (3) The range of plastic failure in the coal seam remains relatively stable under gangue backfill mining, with the plastic zone of the roof plate exhibiting a strip-like distribution; (4) Both range analysis and variance analysis revealed that the sensitivity ranking is backfill collapse ratio > mining height > elastic modulus. …”

FLAC3D code. by Lei Zhu (16642)

“…The results indicate that: (1) The manifestation of mining pressure in gangue backfill mining is influenced by factors such as mining height and backfill collapse ratio; (2) Under the support of coal gangue, the concentrated stress in the coal seam significantly decreases, forming an arched shape according to the mining stages; (3) The range of plastic failure in the coal seam remains relatively stable under gangue backfill mining, with the plastic zone of the roof plate exhibiting a strip-like distribution; (4) Both range analysis and variance analysis revealed that the sensitivity ranking is backfill collapse ratio > mining height > elastic modulus. …”

Establishment of Numerical Model. by Lei Zhu (16642)

“…The results indicate that: (1) The manifestation of mining pressure in gangue backfill mining is influenced by factors such as mining height and backfill collapse ratio; (2) Under the support of coal gangue, the concentrated stress in the coal seam significantly decreases, forming an arched shape according to the mining stages; (3) The range of plastic failure in the coal seam remains relatively stable under gangue backfill mining, with the plastic zone of the roof plate exhibiting a strip-like distribution; (4) Both range analysis and variance analysis revealed that the sensitivity ranking is backfill collapse ratio > mining height > elastic modulus. …”

<i>BgILP1-8</i> expression in different <i>Blattella germanica</i> adult male tissues and in response to starvation. by Viviana Pagone (22086362)

Photomicrographs of H&E-stained cerebellum sections from control and different pregnant mothers: control (A & B) and BM (C & D) groups, showing normal histological structure of the... by Amoura M. Abou-El-Naga (21001524)

Effect of Bcl-xl on the tumorigenicity of MDCK cells in nude mice. by Jiahao Zheng (807470)

Data Sheet 1_Host identity, more than elevation, shapes bee microbiomes along a tropical elevation gradient.pdf by Andrea Pinos (22268176)

“…We applied DNA metabarcoding on the 16S rRNA region of gut samples from five bee tribes: Apini (honey bees), Bombini (bumble bees), Meliponini (stingless bees), Euglossini (orchid bees), and Halictini (sweat bees). …”

An infographic outlining the data used for each analysis. by Shelby L. Sturrock (10751675)

Causal relationships between allergic diseases and significant declines in lung function: a multivariable Mendelian randomization study by Jiannan Lin (6954983)

“…Only allergic asthma continued to show a significant causal relationship with decreased lung function (OR [95%CI]: 1.019 [1.008–1.030], <i>p</i> < .001).…”

Discovery of MKP10241, a Novel Small Molecule Targeting the GPR119/Incretin Axis to Treat Metabolic Disorders by Santosh Kumar Rai (22382996)

“…Chronic treatment of MKP10241 in DIO-mice exhibited marked reduction in body weight and feed intake at tested doses, which was associated with decreased blood glucose level, lipid parameters, and body fats. …”

Image1_The immunological and prognostic significance of the diabetes mellitus-related gene WFS1 in endometrial cancer.tif by Wenzhe Li (815057)

“…First, we identified WFS1 as the target gene and obtained EC data from the TCGA database. …”

Table2_The immunological and prognostic significance of the diabetes mellitus-related gene WFS1 in endometrial cancer.xlsx by Wenzhe Li (815057)

“…First, we identified WFS1 as the target gene and obtained EC data from the TCGA database. …”

Table3_The immunological and prognostic significance of the diabetes mellitus-related gene WFS1 in endometrial cancer.docx by Wenzhe Li (815057)

“…First, we identified WFS1 as the target gene and obtained EC data from the TCGA database. …”