Data_Sheet_1_A novel chimeric endolysin Cly2v shows potential in treating streptococci-induced bovine mastitis and systemic infections.docx by Shuang Wang (46453)

“…With the development of multidrug-resistant bacteria, it is crucial to develop novel antibiotic alternatives. Here, we constructed a novel chimeric endolysin, Cly2v, which comprises the Ply2741 CHAP domain (1-155aa) and the PlyV12 CBD domain (146-314aa). …”

Data Sheet 2_Saikosaponin A induces cellular senescence in triple-negative breast cancer by inhibiting the PI3K/Akt signalling pathway.docx by Yingchao Wu (2870927)

“…Existing therapeutic agents are generally accompanied by significant side effects. Here, we highlight Saikosaponin A (SSA), a promising natural metabolite characterized by low toxicity, demonstrating significant efficacy against breast cancer through the induction of cellular senescence.…”

Table 4_Trends in immune cell profiles of osteomyelitis: a clinical study supported by Mendelian randomization analysis.docx by Zemin Liu (224306)

“…Subgroup analysis revealed significantly increased lymphocyte counts and decreased neutrophil counts across all subgroups, except for the mixed infection group. …”

Table 7_Burden of malaria in the Comoros, 1990–2021: findings from the global burden of disease study 2021.xlsx by Sheng Zhou (66217)

“…Analyzing the malaria burden will aid in designing prevention, control, and eradication strategies based on scientific evidence.</p>Methods<p>We retrieved data from the 2021 Global Burden of Disease (GBD) database to assess the malaria burden in the Comoros in 2021, stratified by sex and age. …”

Table 6_Burden of malaria in the Comoros, 1990–2021: findings from the global burden of disease study 2021.xlsx by Sheng Zhou (66217)

“…Analyzing the malaria burden will aid in designing prevention, control, and eradication strategies based on scientific evidence.</p>Methods<p>We retrieved data from the 2021 Global Burden of Disease (GBD) database to assess the malaria burden in the Comoros in 2021, stratified by sex and age. …”

Table 3_Dose-dependent changes in global brain activity and functional connectivity following exposure to psilocybin: a BOLD MRI study in awake rats.xlsx by Evan Fuini (21224939)

“…This is the first study to use MRI to follow functional changes in brain activity in response to different doses of psilocybin in fully awake, drug naive rats. We hypothesized that psilocybin would show a dose-dependent increase in activity in the prefrontal cortex and thalamus, while decreasing hippocampal activity. …”

Control analyses of behavioral timescales. by Isabel Raposo (21615517)

“…<b>(B)</b> Two location task example: We observed no statistically significant differences between different smoothing windows for the two location task, but for the four location task (two locations: <i>F</i>3,39 = 1.35, <i>p</i> = 0.2727; four locations: <i>F</i>3,39 = 32.15, <i>p</i> < 0.0001, repeated-measures ANOVA). …”

Table 5_OSH45, a homeobox transcription factor, coordinates low-phosphate adaptation in rice.xlsx by Hong Lu (58784)

“…<p>Phosphorus (P), an essential macronutrient critical for plant growth and development, faces significant availability constraints in agricultural soils, substantially limiting crop yield potential. …”

Supplementary file 1_Global, regional, and national total burden related to hepatitis B and attributable risk factors in adults aged 65 years and older from 1990 to 2021 and projec... by Linying Gao (4379200)

“…ASIR and ASPR both showed significant decreasing trends in males and females, with persistently higher rates observed among males across all study years. …”

Supplementary file 1_Association of antenatal dexamethasone administration timing with outcomes in preterm infants in a low- and middle-income country.docx by Vijay Kalrao (22696397)

“…No other secondary outcomes differed significantly.</p>Conclusion<p>Dexamethasone administration within 24 h before delivery did not reduce mortality but significantly decreased the risk of severe NEC. …”

<b>Targeted Metabolomic Profiling Reveals Inflammation – Associated longitudinal</b><b>changes in Plasma Metabolites Following on-pump Coronary Bypass Surgery</b> by Frieder Neu (18393729)

Datafiles and R script for analyses and figures for submitted manuscript titled: Loss of dominant tree-mycorrhizal mutualism increases soil fungal diversity and alters community st... by Lindsay McCulloch (8565423)

“…Fungal alpha diversity was significantly greater in the OG₁₀₀ and OG₅₀ compared to the control, largely driven by decreased ECM abundance and increased saprophytic fungal abundance in OG₁₀₀ and OG₅₀. …”

Table 1_Time trends in mechanical thrombectomy (2017–2021): do real-world data reflect advances in evidence?.docx by Christoph Riegler (3554054)

“…Background<p>In recent years, we have witnessed a continuous, evidence-based expansion of indications for endovascular therapy (EVT) in the treatment of ischaemic stroke, driven by advancements in extended time windows and target vessel occlusion. …”

Data Sheet 1_Global burden of cancer in adolescents and young adults aged 10–24 years: a trend analysis.pdf by Junjun Yang (307892)

“…The age-standardized death rate(ASDR) and age-standardized DALY rate of total cancer have decreased significantly globally in adolescents and young adults aged 10–24 years. …”

Supplementary Material: Spent hemp biomass as a feed ingredient for beef steers: effects on performance, blood parameters, behavior, cannabinoid residues, and consumer exposure lev... by Agung Irawan (14145081)

“…In this study, we investigated the inclusion of SHB in the diet of beef stockers to assess its effect on animal health, performance, and cannabinoid accumulation in meat. …”

Data Sheet 1_Modified life’s essential 8 mediate the correlation between dietary index for gut microbiota and sleep disorders.docx by Juanjuan Fang (413481)

“…We used mediation analysis to assess the intermediary role of mLE8 (Modified Life’s Essential 8) and all its components.…”

Altered spatial distribution of EPDCs in <i>Wt1</i>^Cre; <i>Sox9</i>^fl/fl; <i>R26</i>^mG hearts. by Andrew B. Harvey (21587431)

“…<b>(I)</b> Nearest-neighbor analysis reveals a decreased average distance between GFP+ object centroids and their nearest CD109 + neighbor in <i>Wt1</i>^Cre; <i>Sox9</i>^fl/fl; <i>R26</i>^mG specimens. …”

Pilot study on the impact of HIFU treatment on miRNA profiles in vaginal secretions of uterine fibroids and adenomyosis patients by Wei-Chun Chen (276732)

“…Notably, hsa-miR-7977, hsa-miR-155-5p, hsa-miR-191-5p, and hsa-miR-223-3p showed significant changes in fibroid cases, except in low-energy treatments. hsa-miR-7977 consistently decreased post-treatment, while hsa-miR-155-5p decreased in the least efficient cases. …”

Supplementary file 1_Burden of urogenital congenital anomalies: findings from the global burden of disease study 2021.docx by Yiwei Yue (22307683)

“…Regionally, Southern Sub-Saharan Africa exhibited the highest prevalence, while Oceania and East Asia showed significant increases and decreases, respectively. Decomposition analysis of change in prevalence indicated that, globally, population contributed the most to changes in prevalence, followed by aging and epidemiological change. …”

Data Sheet 1_Successional patterns of microbial communities across various stages of leaf litter decomposition in poplar plantations.pdf by Shuang Hu (182425)

“…With the decomposition of leaf litter, the total N content increased gradually, while other nutrients (C, P, K, cellulose and hemicellulose) decreased progressively. Litter characteristics had significant effects on microbial community structure: C/N, TK and residual hemicellulose (RH) were the primary driving factors affecting fungal community structure, whereas bacterial community structure was influenced by TK, RH, residual cellulose (RC) and lignin contents.…”