Adult demyelination has no effect on PV interneuron’s firing rate or failures in autaptic responses. by Sara Hijazi (21656615)

PRV UL4 augments ASC oligomerization and speck formation. by Xiaohua Zhang (350570)

Remyelination in adulthood leads to an incomplete restoration of PV interneuron properties. by Sara Hijazi (21656615)

“…Average action potential (AP) frequency in response to 0-650 pA current steps illustrating a significant decrease in PV interneuron firing frequency in remyelination (green) mice (<i>group x current two-way repeated measures: n = 25/19 cells from 8 mice per group: F(13,546) = 3.962, ***p < 0.001</i>). …”

Inhibition of foam cell formation. by Bruno Musetti (9527085)

Table 1_Late-onset first epileptic seizure and cerebral small vessel disease: role of juxtacortical white matter lesions.docx by Adrian Nasca (20601542)

“…With regard to total WML volume, LOFES and TIA patients did not differ significantly. Compared to TIA group, LOFES patients gray matter volume was regionally decreased in the right pre- and postcentral gyrus.…”

Image 1_Unveiling the intricacies: small interfering RNA targeting Snail-1 unravels dynamics in endometrial carcinoma cell behavior.jpeg by Feng Li (30515)

“…Moreover, transfection correlated with increased apoptosis and decreased migration of treated HEC-1A cells.</p>Conclusion<p>The study emphasizes the significant influence of Snail-1 on EMT in EC cells, thereby impacting apoptosis and metastasis. …”

Supplementary file 1_Temporal interaction information and laser evoked responses: preliminary results in fibromyalgia patients with small fibers pathology.docx by Livio Clemente (22152382)

“…</p>Results<p>Control subjects generally exhibited synergy clusters corresponding to N2 and P2 peaks, whereas patients with fibromyalgia (FM), particularly those with distal denervation, exhibited increased redundancy and decreased synergy.</p>Conclusion<p>Patients with FM and small fiber pathology exhibited an alteration in higher-order integration mechanisms due to a complex interaction between cortical processing of pain and denervation of nociceptive fibers.…”

Prediction of bacterial BugBase phenotype. by Jun Sun (48981)

Juvenile demyelination induces a loss of functional autapses. by Sara Hijazi (21656615)

“…Cuprizone-treated mice show a significant decrease in the percentage of cells showing an autaptic response (<i>Fisher’s exact test; *p = 0.0173</i>). …”

AUT00201 (1 µM) can rescue AP width in cuprizone mice. by Sara Hijazi (21656615)

“…In the responsive cells from cuprizone mice (red) a significant increase in PV interneuron firing frequency at lower current steps (gray) was observed (<i>group x current two-way repeated measures: n = 8 cells from 4 mice: p = 0.05287; AUT00201 effect: F(1,60) = 5.050, *p = 0.0457. …”

Autapses play a crucial role in PV interneuron’s sustained firing at high frequencies. by Sara Hijazi (21656615)

“…Average action potential (AP) frequency in response to 0−650 pA current steps illustrating a significant increase in PV interneuron firing frequency at low-current steps in control cells without autapses (gray) compared to control cells with autapses (black). …”

Comparison between juvenile and adult demyelination. by Sara Hijazi (21656615)

“…Juvenile demyelination leads to impairment in PV interneuron maturation whereas adult demyelination induces a decrease in the excitability of PV interneurons. Summary data showing the averaged (± s.e.m) of the following intrinsic properties: (A) Resting membrane potential (RMP) (<i>ANOVA: n = 36,30,19,24 cells from 9/8/8/6 mice per group, ****p < 0.0001, post-hoc LSD test: *p < 0.05, **p < 0.01, ****p < 0.0001</i>), (B) Input resistance (IR) (<i>ANOVA: n = 36,30,19,24 cells from 9/8/8/6 mice per group, **p = 0.0024, post-hoc LSD test: *p < 0.05, **p < 0.01, ***p < 0.001</i>), (C) Sag (<i>ANOVA: n = 36,30,19,24 cells from 9/8/8/6 mice per group, **p = 0.0083, post-hoc LSD test: *p < 0.05, **p < 0.01</i>), (D) Rheobase (<i>ANOVA: n = 36,30,19,24 cells from 9/8/8/6 mice per group, p = 0.1230, post-hoc LSD test: *p < 0.05</i>) and (E) Action potential (AP) threshold (<i>ANOVA: n = 36,30,19,24 cells from 9/8/8/6 mice per group, *p = 0.0452, post-hoc LSD test: *p < 0.05</i>), (F) AP half-width (<i>ANOVA: n = 36,30,19,24 cells from 9/8/8/6 mice per group, **p = 0.0058, post-hoc LSD test: **p < 0.01</i>), (G) Average action potential (AP) frequency in response to 0–650 pA current steps illustrating no significant change in S1 PV interneuron firing frequency following juvenile demyelination (<i>group x current two-way repeated measures: n = 36,30,19,24 cells from 9/8/8/6 mice per group: F(39,1,291) = 2.487, ****p < 0.0001</i>) and (H) Maximum firing frequency per group (<i>ANOVA: n = 36,30,19,24 cells from 9/8/8/6 mice per group, ****p < 0.0001, post-hoc LSD test: ***p < 0.001, ****p < 0.0001</i>). …”

Multiscale QM/MM Simulations Identify the Roles of Asp239 and 1‑OH···Nucleophile in Transition State Stabilization in Arabidopsis thaliana Cell-Wall Invertase 1 by Wijitra Jitonnom (22410515)

“…The glycosylation and deglycosylation steps were considered in both wild type and mutants. …”

Differences in mean scores of upper extremity performance in all five accelerometer-derived variables across four time points- pre-HABIT, post-HABIT, 3-month, and 6-month post-HABI... by Shailesh S. Gardas (20490020)

“…<p>Values reported are means ± SEM as determined by distribution of data during each assessment time point. …”

Procedure for attaching the eye drop bottle and instilling eye drops. by Yuka Kasai (21354922)

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Demographics of the enrolled patients. by Yuka Kasai (21354922)

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The video demonstrates how to use the eye drop aid. by Yuka Kasai (21354922)

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Overhead view of the eye drop aid. by Yuka Kasai (21354922)

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Comparison of eye drop instillation success rates across different age groups. by Yuka Kasai (21354922)

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Supplementary Material for: Adjunctive active vitamin D (AVD) decreases kidney function during treatment of secondary hyperparathyroidism (SHPT) with extended-release calcifediol (... by figshare admin karger (2628495)