Supplementary Material for: Dynamics of RTEL1 helicase in meiotic cells: spatiotemporal distribution during prophase I in the rat Rattus norvegicus by figshare admin karger (2628495)

“…As meiosis progresses from early pachytene to diplotene, the significant decrease in RTEL1 and RPA signals underscores their predominant involvement in early prophase I. …”

DataSheet2_Bidirectional two-sample Mendelian randomization analysis investigates causal associations between cathepsins and inflammatory bowel disease.DOCX by Na Wang (193263)

“…</p>Results<p>The forward MR analyses showed no significant association between cathepsins and IBD. …”

Image 1_Multi-omics analysis reveals neutrophil heterogeneity and key molecular drivers in sepsis-associated acute kidney injury.jpg by Tianle Cheng (20788417)

“…This study employed a multi-omics approach, integrating single-cell and bulk RNA sequencing from 21 sepsis samples and Escherichia coli-induced sepsis datasets, alongside bioinformatics, machine learning, and experimental validation in a rat model and human peripheral blood. We identified four neutrophil subtypes—pro-inflammatory, anti-inflammatory, mature, and immature—revealing a significant increase in pro-inflammatory neutrophils in sepsis (40.53% versus 4.19% in controls) and a decrease in anti-inflammatory neutrophils (18.43% versus 27.04%). …”

Image 2_Multi-omics analysis reveals neutrophil heterogeneity and key molecular drivers in sepsis-associated acute kidney injury.jpg by Tianle Cheng (20788417)

“…This study employed a multi-omics approach, integrating single-cell and bulk RNA sequencing from 21 sepsis samples and Escherichia coli-induced sepsis datasets, alongside bioinformatics, machine learning, and experimental validation in a rat model and human peripheral blood. We identified four neutrophil subtypes—pro-inflammatory, anti-inflammatory, mature, and immature—revealing a significant increase in pro-inflammatory neutrophils in sepsis (40.53% versus 4.19% in controls) and a decrease in anti-inflammatory neutrophils (18.43% versus 27.04%). …”

Sensitivity indices of the model parameters for . by Sisay Fikadu Jaleta (20912783)

“…<div><p>Malaria remains a significant global health challenge, particularly in developing countries. …”

Table 2_Flammulina velutipes mycorrhizae dietary fiber attenuates the development of obesity via regulating lipid metabolism in high-fat diet-induced obese mice.xlsx by Fengjuan Jia (703605)

“…Introduction<p>Mounting evidence has shown that Flammulina velutipes mycorrhizae dietary fiber (Fv-DF) has the potential to significantly improve health outcomes by addressing lipid metabolic disorders. …”

Infected mosquitoes with fractional order and.. by Sisay Fikadu Jaleta (20912783)

“…<div><p>Malaria remains a significant global health challenge, particularly in developing countries. …”

Data Sheet 1_Low hydrostatic pressure promotes functional homeostasis of nucleus pulposus cells through the TRPV4/CRT/FA complex axis.zip by Junxian Hu (8158044)

“…CRT also exhibits distinct roles depending on its subcellular localization. In this study, we observed that under low hydrostatic pressure, TRPV4 activation and subsequent calcium influx led to an increase in CRT synthesis and a significant rise in its cytosolic expression. …”

Data Sheet 1_Synergistic remediation of continuous cropping obstacles in facility agriculture: insights from the Stropharia rugosoannulata-Ornamental Sunflower Rotation System.docx by Jia Lu (181094)

“…The SR-OS2 system significantly enhanced soil properties by increasing pH (+0.57 units), decreasing electrical conductivity (−37.56%), and boosting available phosphorus (+84.2%), while also shifting microbial communities toward bacterial dominance with a 37.4% increase in bacterial Chao1 diversity and a 39.1% decrease in fungal diversity, alongside strengthened bacterial connectivity (+42%) and reduced fungal modularity in co-occurrence networks. …”

Table2_Bidirectional two-sample Mendelian randomization analysis investigates causal associations between cathepsins and inflammatory bowel disease.XLSX by Na Wang (193263)

“…</p>Results<p>The forward MR analyses showed no significant association between cathepsins and IBD. …”

Table3_Bidirectional two-sample Mendelian randomization analysis investigates causal associations between cathepsins and inflammatory bowel disease.XLSX by Na Wang (193263)

“…</p>Results<p>The forward MR analyses showed no significant association between cathepsins and IBD. …”

None - by Sisay Fikadu Jaleta (20912783)

“…<div><p>Malaria remains a significant global health challenge, particularly in developing countries. …”

Supplementary Material for: Global, regional, and national epidemiology of Idiopathic Childhood Epilepsy from 1990 to 2021 by figshare admin karger (2628495)

“…Regionally, Southern Latin America saw the largest increase in incidence (EAPC, 0.49), and Eastern Europe observed the most significant mortality decrease (EAPC, -4.65). Ecuador reported the highest incidence rate, Tajikistan the highest mortality, and Zambia the highest DALYs in 2021. …”

Table 1_Effect of high-intensity intermittent rehabilitation training on physical function, gut microbiome and metabolite after percutaneous coronary intervention in patients with... by Lei Jiang (73366)

“…</p>Results<p>The 6MWT showed significantly greater improvement in the HIIT group compared to the MCT group (P = 0.0024). …”

Table 1_MiR-216a-3p inhibits the cytotoxicity of primary natural killer cells.xlsx by Rowan Abdelbary (20589248)

“…Among those targets is FOXO-1, which has been reported to play a role in NK cell maturation. Thus, we evaluated FOXO-1 expression upon mimicking miR-216a-3p in control NK cells that showed significant downregulation of FOXO-1 on both RNA and protein levels.…”

Engineered deletions of 1-TbAd biosynthesis genes reveal gene functions and greatly expand the lipid signature. by Jacob A. Mayfield (19762468)

“…Events with >4-fold decrease in all 3 mutants and <i>p</i> < 0.001 (Benjamini–Hochberg adjusted <i>p</i> value of the F-test) are shown in black. …”

Image 1_SQLE-mediated squalene metabolism promotes tumor immune evasion in pancreatic cancer.tif by Junchen Pan (19417598)

“…RT-PCR and Western blot analyses were used to investigate the relevant molecular mechanisms.</p>Results<p>We show that SQLE is significantly overexpressed in pancreatic cancer, and abrogation of SQLE results in a significant increase in squalene accumulation within tumor cells. …”

Table 4_Tracing priming effects in palsa peat carbon dynamics using a stable isotope-assisted metabolomics approach.csv by Christian Ayala-Ortiz (15255371)

“…Through this approach, we achieved molecule-specific tracking of carbon transformations at unprecedented detail.…”

Data Sheet 3_Global, regional, and national epilepsy of unknown cause incidence and mortality, 1990–2036: cross-national health inequalities and predictive analytics.pdf by Lijun Wang (176511)

“…It is crucial to describe and forecast cross-national health disparities in terms of years lived with disability (YLDs) for the forthcoming 15-year period. We examined and projected trends in the burden of disease and cross-national inequalities in epilepsy of unknown cause globally, by region and country from 1990 to 2036.…”

Data Sheet 4_Global, regional, and national epilepsy of unknown cause incidence and mortality, 1990–2036: cross-national health inequalities and predictive analytics.pdf by Lijun Wang (176511)

“…It is crucial to describe and forecast cross-national health disparities in terms of years lived with disability (YLDs) for the forthcoming 15-year period. We examined and projected trends in the burden of disease and cross-national inequalities in epilepsy of unknown cause globally, by region and country from 1990 to 2036.…”