Knockdown of <i>fhplk1</i> disrupts growth and cell proliferation in juvenile <i>Fasciola hepatica in vitro.</i> by Paul McCusker (634425)

“…<b>(C)</b> Mean # EdU⁺ nuclei ±SEM significantly decreased after four weeks of <i>fhplk1</i> dsRNA treatments in juvenile <i>F. hepatica</i> (n ≥ 15 for each treatment; Mann-Whitney U test). …”

Primer pairs for RT-qPCR. by Yoichi Kurokawa (22290520)

“…Conversely, exposure to endogenous prooxidants (dopamine and adrenaline), certain food-derived polyphenols (chrysin and 3-<i><i>O</i></i>-methylquercetin), or 1,2-naphthoquinone led to a significant decrease (<0.5-fold) in Rmst expression. …”

RT-qPCR data tables. by Yoichi Kurokawa (22290520)

“…Conversely, exposure to endogenous prooxidants (dopamine and adrenaline), certain food-derived polyphenols (chrysin and 3-<i><i>O</i></i>-methylquercetin), or 1,2-naphthoquinone led to a significant decrease (<0.5-fold) in Rmst expression. …”

Information of core targets. by Guobing Wang (288885)

“…The difference between the single drug group and the corresponding low dose group was significant (P<0.001). After Hela cells were cultured for 72 h, the mRNA and protein expressions corresponding to EGFR, TNF-α, VEGFA, PI3K, AKT and MDM2 were decreased in the experimental group compared with the control group as confirmed by RT-PCR and Western blot, and the extent of the decrease was more obvious with the increase of the drug concentration, and under the condition of the same drug dosage, the effect of the Baicalein group was more pronounced than that of the Wogonin group, and the effect was more obvious in the two-drug group compared with the single-drug group (P<0.05).…”

Composition of Scutellaria Barbata. by Guobing Wang (288885)

“…The difference between the single drug group and the corresponding low dose group was significant (P<0.001). After Hela cells were cultured for 72 h, the mRNA and protein expressions corresponding to EGFR, TNF-α, VEGFA, PI3K, AKT and MDM2 were decreased in the experimental group compared with the control group as confirmed by RT-PCR and Western blot, and the extent of the decrease was more obvious with the increase of the drug concentration, and under the condition of the same drug dosage, the effect of the Baicalein group was more pronounced than that of the Wogonin group, and the effect was more obvious in the two-drug group compared with the single-drug group (P<0.05).…”

GO function enrichment analysis. by Guobing Wang (288885)

“…The difference between the single drug group and the corresponding low dose group was significant (P<0.001). After Hela cells were cultured for 72 h, the mRNA and protein expressions corresponding to EGFR, TNF-α, VEGFA, PI3K, AKT and MDM2 were decreased in the experimental group compared with the control group as confirmed by RT-PCR and Western blot, and the extent of the decrease was more obvious with the increase of the drug concentration, and under the condition of the same drug dosage, the effect of the Baicalein group was more pronounced than that of the Wogonin group, and the effect was more obvious in the two-drug group compared with the single-drug group (P<0.05).…”

KEGG functional enrichment analysis. by Guobing Wang (288885)

“…The difference between the single drug group and the corresponding low dose group was significant (P<0.001). After Hela cells were cultured for 72 h, the mRNA and protein expressions corresponding to EGFR, TNF-α, VEGFA, PI3K, AKT and MDM2 were decreased in the experimental group compared with the control group as confirmed by RT-PCR and Western blot, and the extent of the decrease was more obvious with the increase of the drug concentration, and under the condition of the same drug dosage, the effect of the Baicalein group was more pronounced than that of the Wogonin group, and the effect was more obvious in the two-drug group compared with the single-drug group (P<0.05).…”

Effects of receptor blockers on VO-induced hypertrophy in published experiments and the calibrated model. by Johane H. Bracamonte (12883844)

“…Blue coloring of boxplot indicates predicted decrease in >75% of simulations, gray boxplots indicate mixed simulation results, filled markers indicate experimental means associated with statistically significant effects and open markers indicate means associated with non-significant effects.…”

Minimal data set. by Zhaoping Meng (4875040)

“…Over-exploitation of wild resources led to the rise of cultivation, along with a decrease in quality. Exposure of plants to adversity must generate substantial quantities of reactive oxygen species (ROS) and result in cellular damage. …”

Predicting Dinitrogen Activation and Coupling with Carbon Dioxide and Other Small Molecules by Methyleneborane: A Combined DFT and Machine Learning Study by Feiying You (22119041)

“…The capture of carbon dioxide is extremely important due to the increasingly severe greenhouse effect, and the conversion of dinitrogen into high-value N–C compounds is of great significance. Here, we predict through density functional theory calculations that the coupling of dinitrogen with carbon dioxide by methyleneborane becomes favorable both thermodynamically and kinetically. …”

Canonical Pathways. by Muhammad N. Aslam (6598001)

“…When cumulative pre-post differences were compared between the Aquamin and placebo groups, Aquamin treatment significantly decreased these differences (a 24% decrease as compared to a 38% increase with placebo, p = 0.0284). …”

Fragmentation patterns for Schisandrin A. by Zhaoping Meng (4875040)

“…Over-exploitation of wild resources led to the rise of cultivation, along with a decrease in quality. Exposure of plants to adversity must generate substantial quantities of reactive oxygen species (ROS) and result in cellular damage. …”

Chemical structure of a lignan. by Zhaoping Meng (4875040)

“…Over-exploitation of wild resources led to the rise of cultivation, along with a decrease in quality. Exposure of plants to adversity must generate substantial quantities of reactive oxygen species (ROS) and result in cellular damage. …”

Development of Novel PRMT7 Inhibitors for the Treatment of Prostate Cancer by Jiaxing Li (113609)

“…<b>A33</b> significantly inhibited the proliferation, colony formation, migration, and invasion of PCa cells and induced substantial cell cycle arrest and apoptosis. …”

Development of Novel PRMT7 Inhibitors for the Treatment of Prostate Cancer by Jiaxing Li (113609)

“…<b>A33</b> significantly inhibited the proliferation, colony formation, migration, and invasion of PCa cells and induced substantial cell cycle arrest and apoptosis. …”

Development of Novel PRMT7 Inhibitors for the Treatment of Prostate Cancer by Jiaxing Li (113609)

“…<b>A33</b> significantly inhibited the proliferation, colony formation, migration, and invasion of PCa cells and induced substantial cell cycle arrest and apoptosis. …”

Development of Novel PRMT7 Inhibitors for the Treatment of Prostate Cancer by Jiaxing Li (113609)

“…<b>A33</b> significantly inhibited the proliferation, colony formation, migration, and invasion of PCa cells and induced substantial cell cycle arrest and apoptosis. …”

Molecular Logic Gate for Sensing pH/Peroxynitrite with Potential Applications in Cisplatin Treatment by Lifang Guo (1460884)

“…With this probe, the significant roles of pH and ONOO^– in cisplatin treatment are disclosed, in which the cell account shows a dramatic reduction accompanied by decreased pH and upregulated ONOO^– levels. …”

Variation of shear stress during the pullout of a single fiber with respect to the shear strain [41]. by Ping Gao (172038)

Bioclimatic variables used for MaxEnt modeling. by Dong-Joo Kim (1797640)

“…Under the SSP2-4.5 scenario, potential suitable area for <i>S. koreana</i> increased, while those for <i>B. ermanii</i>, <i>T. cuspidata</i> decreased by the 2090s. Under the SSP5-8.5 scenario, suitable areas for <i>S. koreana</i>, <i>B. ermanii</i>, <i>T. cuspidata</i> decreased by 33.6%, 98.9%, and 90.1%, respectively. …”