Discovery of an Orally Active PDE1 Inhibitor for Disease-Modifying Treatment of Postmenopausal Osteoporosis via Dual Anabolic-Antiresorptive Mechanisms by Farman M. Abbasi (22318766)

“…In ovariectomized mice, <b>5cc</b> administration (5 mg/kg) improved the trabecular microarchitecture, bone mineral density, and strength, at levels comparable to teriparatide, while significantly reducing bone resorption markers. With 13.57% oral bioavailability and selectivity for PDE1A1 (32% inhibition at 500 nM), <b>5cc</b> offers an innovative therapeutic candidate for PMO with a dual anabolic-antiresorptive profile and oral efficacy, warranting further clinical development.…”

Discovery of an Orally Active PDE1 Inhibitor for Disease-Modifying Treatment of Postmenopausal Osteoporosis via Dual Anabolic-Antiresorptive Mechanisms by Farman M. Abbasi (22318766)

“…In ovariectomized mice, <b>5cc</b> administration (5 mg/kg) improved the trabecular microarchitecture, bone mineral density, and strength, at levels comparable to teriparatide, while significantly reducing bone resorption markers. With 13.57% oral bioavailability and selectivity for PDE1A1 (32% inhibition at 500 nM), <b>5cc</b> offers an innovative therapeutic candidate for PMO with a dual anabolic-antiresorptive profile and oral efficacy, warranting further clinical development.…”

Effect of <i>CrBV3-31</i> interference on the performance of <i>Cotesia ruficrus</i> offspring. by Xian Li (201841)

Gene inactivation by RNAi of the synMuv suppressor genes encoding the chromatin remodeling and histone methylation factors <i>isw-1</i> and <i>mes-4</i> significantly suppresses th... by Ashwin Seetharaman (615458)

Heterogeneity analysis. by Ying Zhao (16546)

“…Instrumental variables (IVs) were identified as genome-wide significant single-nucleotide polymorphisms (SNPs) with a significance threshold of <i>P </i>< 1 × 10⁻⁸ and an independence criterion of <i>r</i>² < 0.001. …”

Reverse MR analysis data. by Ying Zhao (16546)

“…Instrumental variables (IVs) were identified as genome-wide significant single-nucleotide polymorphisms (SNPs) with a significance threshold of <i>P </i>< 1 × 10⁻⁸ and an independence criterion of <i>r</i>² < 0.001. …”

SNP dressing by screening. by Ying Zhao (16546)

“…Instrumental variables (IVs) were identified as genome-wide significant single-nucleotide polymorphisms (SNPs) with a significance threshold of <i>P </i>< 1 × 10⁻⁸ and an independence criterion of <i>r</i>² < 0.001. …”

Sensitivity analysis. by Ying Zhao (16546)

A trend in the discussion of additional factors and by-products of depression. by Seoyoung Kim (2603596)

O-ag length and composition impacts complement activation by <i>Salmonella</i> nontyphoidal and enteric fever serovars. by Fermin E. Guerra (6084545)

Decomposition of changes in the number of CRC burden in East Asian countries, the United States, and globally, 1990–2021. by Yuanyi Cao (22394797)

Effect of O-ag modifying glycosyltransferases on complement activation and <i>Salmonella</i> interactions with human serum. by Fermin E. Guerra (6084545)

“…</i> Paratyphi A decrease complement activation as measured by C5a release and (B) IgM binding. …”

Reduction of L O-ag production and antigenic shift to O2-antigen in by Fermin E. Guerra (6084545)

“…<p><b><i>S.</i> Paratyphi A decreases IgM binding. (</b>A) and (B) Restored <i>S.…”

Continuing evolution of H5N1 highly pathogenic avian influenza viruses of clade 2.3.2.1a G2 genotype in domestic poultry of Bangladesh during 2018–2021 by Mohammed Nooruzzaman (3175290)

“…Consequently, antigenic analysis revealed a significant loss of cross-reactivity between viruses from different host species and periods. …”

The contribution of O-ag length and the Vi capsule to serum resistance is serovar dependent. by Fermin E. Guerra (6084545)

Variation law of AE <i>b</i>-value of sandstone under different freeze-thaw cycles at a loading rate of 0.20mm/min. by Wenyu Lv (20139458)

Variation law of AE <i>b</i>-value of sandstone under different freeze-thaw cycles at a loading rate of 0.05 mm/min. by Wenyu Lv (20139458)

Period-specific relative risks (RRs) for CRC burden by sex in East Asian countries, the United States, and globally, based on the age-period-cohort model. by Yuanyi Cao (22394797)

Age-specific relative risks (RRs) for CRC burden by sex in East Asian countries, the United States, and globally, based on the age-period-cohort model. by Yuanyi Cao (22394797)

Cohort-specific relative risks (RRs) for CRC burden by sex in East Asian countries, the United States, and globally, based on the age-period-cohort model. by Yuanyi Cao (22394797)