Data Sheet 1_Metastatic organ count stratifies survival in immunotherapy-treated metastatic colorectal cancer: a retrospective cohort study.docx by Hai-Yan Fu (1586935)

“…</p>Conclusions<p>Increased metastatic organ count in patients with mCRC was associated with decreased immunotherapy ORR and worse prognosis, with a particularly pronounced effect observed in patients with lung metastasis.…”

Image 1_CD3zeta-mediated modulation of TCR signaling: a novel strategy for neuroprotection in retinal ganglion cell degeneration.jpeg by Kexin Xu (757891)

“…The neuroprotective effect of CD3ζ knockdown was accompanied by the restoration of MAPK signaling, specifically the phosphorylation of ERK and p38, and attenuation of NF-κB activation, indicated by decreased p65 phosphorylation. Furthermore, CD3ζ knockdown reduced the levels of proinflammatory mediators (IL-1β, TNF-α, and MMP-9) and increased that of the anti-inflammatory cytokine IL-10, creating a retinal microenvironment conducive to neuroprotection.…”

Table 1_Prevalence and prognostic value of sarcopenia in patients with bladder cancer undergoing radical cystectomy: a systematic review and meta-analysis.docx by Lei Zhang (38117)

“…Some studies have identified sarcopenia as a potential prognostic indicator associated with reduced survival following radical cystectomy (RC).…”

Table 1_Interaction between dietary selenium intake and age on severe headache or migraine in the United States: a population-based study.docx by Xinping Yu (555177)

“…The OR of developing migraine was 0.97 (95% CI: 0.94–0.98) in individuals with selenium intake ≥101.9 ug/day in adults with 20–50 years.</p>Conclusion<p>A higher dietary selenium intake is significantly associated with a decreased prevalence of migraine, and age can modify the association between them. …”

Data Sheet 1_Identification of a multiple DAMP scavenger mimicking the DAMP-binding site of TLR4 to ameliorate lethal sepsis.pdf by Takuya Murao (114383)

“…In vitro, OP18 reduced the production of the inflammatory cytokine TNF-α in DAMP-activated macrophages and restored mitochondrial function, as evidenced by improved oxygen consumption rate (OCR) and ATP production. In a lethal sepsis model induced by cecal ligation and puncture (CLP), DAMP levels were significantly elevated, while OP18 treatment markedly reduced the serum DAMP levels. …”

Image 1_Interaction between dietary selenium intake and age on severe headache or migraine in the United States: a population-based study.pdf by Xinping Yu (555177)

“…The OR of developing migraine was 0.97 (95% CI: 0.94–0.98) in individuals with selenium intake ≥101.9 ug/day in adults with 20–50 years.</p>Conclusion<p>A higher dietary selenium intake is significantly associated with a decreased prevalence of migraine, and age can modify the association between them. …”

Image 1_A four-gene signature identified by integrated transcriptomic analysis for differential diagnosis and prognosis of uterine smooth muscle tumors.pdf by Huiyi Hu (11226995)

“…Moreover, survival analysis revealed the prognostic significance of this four-gene signature: high TOP2A with low ABLIM1, FHL5, and MAP3K8 expression correlated with decreased overall survival in ULMS, implicating their potential role as diagnostic and prognostic markers. …”

Table1_Effect of inflammatory cytokines and plasma metabolome on OSA: a bidirectional two- sample Mendelian randomization study and mediation analysis.pdf by Xin Sun (127355)

“…Background<p>Obstructive sleep apnea (OSA) is a common sleep disorder. Inflammatory factors and plasma metabolites are important in assessing its progression. …”

Table 2_Expression, prognosis and preliminary investigation of the mechanism of action of ACTR6, a member of the ARPs gene family, in hepatocellular carcinoma.xlsx by Jing Wang (6206297)

“…Functionally, knocking down ACTR6 inhibited cell migration and proliferation, produced a G1 cell cycle arrest, and decreased the viability of liver cancer cells.…”

Table_1_Biological characterization and in vitro fungicide screening of a new causal agent of walnut leaf spot in Guizhou Province, China.DOCX by Xianxi Ao (19822227)

“…Increasing the light period significantly decreased conidia production and conidia germination. …”

Table1_Causal association between inflammatory bowel disease and acute pancreatitis: a two-sample bidirectional mendelian randomization study.XLSX by Cong Zhang (582922)

“…However, Crohn’s disease (CD) (OR = 1.023, 95% CI = 0.993-1.055, p = 0.134) did not show a causal association with the risk of AP. Interestingly, AP was suggestively associated with a decreased risk of CD (OR = 0.797, 95% CI = 0.637-0.997, p = 0.047). …”

Image 1_Expression, prognosis and preliminary investigation of the mechanism of action of ACTR6, a member of the ARPs gene family, in hepatocellular carcinoma.tif by Jing Wang (6206297)

“…Functionally, knocking down ACTR6 inhibited cell migration and proliferation, produced a G1 cell cycle arrest, and decreased the viability of liver cancer cells.…”

Table1_Causal association between inflammatory bowel disease and acute pancreatitis: a two-sample bidirectional mendelian randomization study.XLSX by Cong Zhang (582922)

“…However, Crohn’s disease (CD) (OR = 1.023, 95% CI = 0.993-1.055, p = 0.134) did not show a causal association with the risk of AP. Interestingly, AP was suggestively associated with a decreased risk of CD (OR = 0.797, 95% CI = 0.637-0.997, p = 0.047). …”

Image 2_Expression, prognosis and preliminary investigation of the mechanism of action of ACTR6, a member of the ARPs gene family, in hepatocellular carcinoma.tif by Jing Wang (6206297)

“…Functionally, knocking down ACTR6 inhibited cell migration and proliferation, produced a G1 cell cycle arrest, and decreased the viability of liver cancer cells.…”

Table 1_Expression, prognosis and preliminary investigation of the mechanism of action of ACTR6, a member of the ARPs gene family, in hepatocellular carcinoma.docx by Jing Wang (6206297)

“…Functionally, knocking down ACTR6 inhibited cell migration and proliferation, produced a G1 cell cycle arrest, and decreased the viability of liver cancer cells.…”

Data Sheet 1_A taste of one’s own medicine: Bacillus velezensis isolated from adult housefly intestines demonstrates effective fly control.pdf by Ying Li (38224)

“…Additionally, we observed a significant decrease in immune response in housefly larvae, with a reduction in phenoloxidase activity and melanization ability in treated larvae compared to controls.…”

Data Sheet 1_Overarching view of trends and disparities in malignant neoplasm of the ovary between 1999-2023: a comprehensive CDC WONDER database study.docx by Jaikin Patel (22555844)

“…All races analyzed saw a decrease in overall mortality related to malignant neoplasms of the ovary, with the largest decrease being observed in White patients (AAPC: -1.78). …”

Supplementary file 1_Effect of herbal medicine Bojungikgi-tang on gut microbiome and symptoms in anorexic patients with atopic dermatitis: a randomized controlled trial.docx by Boram Lee (549836)

“…Among the serum cytokines, IL-1β significantly decreased only in the BJT group, while IL-4 and IL-17 significantly decreased in both groups, with a more pronounced reduction observed in the BJT group. …”

Jitter plot illustrating the distribution of three racial groups across varying rural percentages. by Michael Bradfield (3540005)

Plots summarising the fixed effect coefficient estimates from fitting the generalised linear mixed effects models to contact matrices calculated at a resolution of 10 kb. by Tze Yee Lim (22057822)

“…(A) Model fit to the RMV7 Hi-C data. (B) Model fit to the RMV7 Pore-C data. …”