Flow chart of the study process. by Wan-Jing Zhen (20427813)

“…</p><p>Conclusions</p><p>This study elucidated the interplay between metabolism and the immune microenvironment in SIC, providing fresh perspectives on the investigation of potential SIC pathogenesis. PDHB emerged as a significant biomarker of SIC, with implications on its progression through the regulation of ERS and metabolism.…”

The degree score of 13 DE-ERSRGs. by Wan-Jing Zhen (20427813)

“…</p><p>Conclusions</p><p>This study elucidated the interplay between metabolism and the immune microenvironment in SIC, providing fresh perspectives on the investigation of potential SIC pathogenesis. PDHB emerged as a significant biomarker of SIC, with implications on its progression through the regulation of ERS and metabolism.…”

DE-ERSRGs-chemical interactive network. by Wan-Jing Zhen (20427813)

“…</p><p>Conclusions</p><p>This study elucidated the interplay between metabolism and the immune microenvironment in SIC, providing fresh perspectives on the investigation of potential SIC pathogenesis. PDHB emerged as a significant biomarker of SIC, with implications on its progression through the regulation of ERS and metabolism.…”

Data. by Rim Kooli (15426816)

“…The level of oxidative stress in sperm was significantly decreased after 24h of incubation with PRP at 2% (p = 0.001), 5% (p = 0.001) and 10% (p = 0.001) when compared to the control group. …”

Primer sequences and information. by Lai Jiang (2401513)

“…This study focuses on the role of the TRIM37-PEX5 axis in regulating oxidative stress in oligodendrocytes and myelin repair, exploring its potential as a novel therapeutic target for MS. Through bioinformatics analysis, TRIM37 was found to be significantly downregulated in MS patients. …”

The original plotting data. by Hongmei Qian (538647)

“…<div><p>Background</p><p>Glaucoma, characterized by a high incidence and significant ocular harm, has been elucidated through various mechanisms. …”

Averaged pupillary responses in bright and dark conditions. by Tomoe Hayakawa (20978784)

Clinical prognosis analysis. by Wan-Jing Zhen (20427813)

Cox model of LASSO model gene. by Wan-Jing Zhen (20427813)

Experimental validation. by Wan-Jing Zhen (20427813)

GO and KEGG analysis. by Wan-Jing Zhen (20427813)

Identification of gene co-expression modules associated with MS. by Lai Jiang (2401513)

Semen characteristics in the study population. by Rim Kooli (15426816)

“…The level of oxidative stress in sperm was significantly decreased after 24h of incubation with PRP at 2% (p = 0.001), 5% (p = 0.001) and 10% (p = 0.001) when compared to the control group. …”

Correlation analysis of DE-ERSRGs. by Wan-Jing Zhen (20427813)

Differential analysis of SIC. by Wan-Jing Zhen (20427813)

WGCNA selection of SIC disease-related modules co-expressed genes. by Wan-Jing Zhen (20427813)

Overexpression <i>TRIM37</i> enhances PEX5 protein stability by promoting PEX5 monoubiquitination. by Lai Jiang (2401513)

Sequence of <i>DpAP2</i> promoter. by Lingru Ruan (18995544)

“…It was speculated that MeJA significantly decreased expression of <i>DpAP2</i> gene, then the decreasing <i>DpAP2</i> expression significantly inhibited expression of some key enzyme genes such as <i>PSY</i>, <i>PDS</i> and <i>GGPS</i> in carotenoid biosynthesis pathway. …”

Predicted <i>cis</i>-acting elements in <i>DpAP2</i> promoter. by Lingru Ruan (18995544)

“…It was speculated that MeJA significantly decreased expression of <i>DpAP2</i> gene, then the decreasing <i>DpAP2</i> expression significantly inhibited expression of some key enzyme genes such as <i>PSY</i>, <i>PDS</i> and <i>GGPS</i> in carotenoid biosynthesis pathway. …”

Schematic diagram of the molecular mechanism by which TRIM37 improves MS by stabilizing PEX5 through monoubiquitination. by Lai Jiang (2401513)