Data Sheet 1_Global, regional, and national burden of hyperglycemia-associated colorectal cancer, 1990-2021: a systemic analysis for the Global Burden of Disease study.zip by Yijuan Liu (5195747)

“…Background<p>Colorectal cancer (CRC) is a leading gastrointestinal malignancy with rising incidence. …”

Table 1_The effects of pond purification system on intestinal function of channel catfish (Ictalurus punctatus): a focus on intestinal development, digestion and absorption, and ju... by Zhong-Bing Zheng (22253200)

“…The intestinal morphology of these channel catfish exhibited increased villus height and a reduced number of mucus cells. Furthermore, serum levels of diamine oxidase and D-lactic acid were significantly decreased in channel catfish raised in the PPS group, while the expression of genes related to the apical junction complex was significantly upregulated, suggesting improved intestinal structural integrity. …”

Supplementary file 2_Effects of Lactiplantibacillus plantarum DSM 33464 in children with elevated blood lead levels: a randomized, double-blind, placebo-controlled study.docx by Wenjing Ji (720509)

“…Probiotics, combined with a multivitamin/mineral supplement, significantly reduced the BLLs in these children within 12 weeks of supplementation by 40%, similar to that of the control group, which received a placebo plus multivitamin/mineral supplement. …”

Supplementary file 1_Effects of Lactiplantibacillus plantarum DSM 33464 in children with elevated blood lead levels: a randomized, double-blind, placebo-controlled study.docx by Wenjing Ji (720509)

“…Probiotics, combined with a multivitamin/mineral supplement, significantly reduced the BLLs in these children within 12 weeks of supplementation by 40%, similar to that of the control group, which received a placebo plus multivitamin/mineral supplement. …”

Data Sheet 1_Application of compost amended with biochar on the distribution of antibiotic resistance genes in a soil–cucumber system—from the perspective of high-dose fertilizatio... by Shuai Shi (333614)

“…Compost application to soils significantly decreased ARG abundance in cucumbers; SBTC had the most significant effect and reduced the number of host bacteria at the phylum level from four to three. …”

Data Sheet 1_Impacts of DRG point-based payment system on healthcare resource utilization and provider behavior: a pilot quasi-experimental study in China.docx by Xiao Huang (223709)

“…Background<p>Developing countries commonly face challenges regarding budget constraints and inadequate cost-accounting capabilities during the implementation of a Diagnosis-Related Group (DRG) payment system. …”

Data Sheet 1_Do you speak cat? Assessing the impact of a training video on human recognition of cat emotions and behaviours during play interactions.pdf by Julia S. L. Henning (22302784)

“…Previous vocational cat experience was associated with higher accuracy in negative interactions. Training had a small but significant positive impact on overall performance but paradoxically significantly decreased subtle negative behaviour recognition. …”

Data Sheet 1_Comprehensive analysis of metabolism-related genes in sepsis reveals metabolic–immune heterogeneity and highlights GYG1 as a potential therapeutic target.csv by Jie Zheng (31208)

“…In vivo, Gyg1 was markedly upregulated in septic mice, and LNP-mediated siRNA knockdown of Gyg1 significantly improved survival in the LPS model. Mechanistically, Gyg1 knockdown significantly reduced glycogen content in myeloid cells, attenuated IL-6 and TNF-α production, alleviated LPS-induced neutrophil, and modestly decreased CD40 expression in monocytes and dendritic cells. …”

S1 File - by Dan Liu (108669)

“…Western Blot analysis indicated a significant reduction of G6PD expression in the retina, and immunofluorescence staining showed distribution of G6PD especially in the retinal endothelium cell decreased.…”

DataSheet1_Causal effects of serum calcium, phosphate, and 25-hydroxyvitamin D on kidney function: a genetic correlation, pleiotropic analysis, and Mendelian randomization study.zi... by Yanjun Liang (4394089)

“…Similarly, serum P was associated with a decrease in eGFRcrea (beta −0.01, P-value 2.0E−04; beta −0.005, P-value 2.0E−03) and an increase in BUN (beta 0.02, P-value 3.0E−03; beta 0.02, P-value 7.5E−07). …”

Table 1_Decadal trends and regional disparities in tuberculosis burden: a comprehensive analysis of global, African, and Southeast Asian data from the GBD 1990–2021.docx by Shiwei Xie (3617159)

“…</p>Conclusion<p>TB remains a significant public health issue, especially in Africa and Southeast Asia. …”

Schematic model depicting the relationship between lipids and proteins by target gene knockdown. by Takuya Kitamoto (11721639)

“…Non-significant but decreasing trends are marked with small light blue arrows pointing downwards. …”

Sensitivity of modeled cell trajectories to parameter perturbations. by Renad Al-Ghazawi (22411258)

Image 1_Snowmelt seepage fluxes of dissolved organic matter in forest and grassland – a molecular-level case study from the Hainich Critical Zone Exploratory, Germany.pdf by Chen Huang (202847)

“…This study, conducted at the Hainich Critical Zone Exploratory in Germany, seeks to address a significant gap in understanding the molecular impacts of snowmelt-induced DOM flows and their ability to alter soil ecosystems rapidly. …”

Participant interview topics. by Lex D. de Jong (22138778)

“…</p><p>Conclusion</p><p>Using a valgus brace decreased knee pain intensity during walking activities. …”

The participants’ baseline characteristics. by Lex D. de Jong (22138778)

“…</p><p>Conclusion</p><p>Using a valgus brace decreased knee pain intensity during walking activities. …”

Data Sheet 1_A zebrafish model of crim1 loss of function has small and misshapen lenses with dysregulated clic4 and fgf1b expression.docx by Tien Le (634791)

“…We used Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 to make a stable Danio rerio model of crim1 deficiency, generating zebrafish that were homozygous for a 2 basepair deletion, c.339_340delCT p.Leu112Leufs*, in crim1.…”

Table 1_Association of serum iron with all-cause mortality and cardiovascular mortality in the cardiovascular patients: a retrospective cohort study based on the NHANES 1999–2018.d... by Jing Lu (120666)

“…</p>Conclusion<p>Higher SI is associated with a decreased risk of all-cause and cardiovascular mortality in CVD patients. …”

Image 1_Multi level effects of Sanghuang Tongxie Formula on type 2 diabetes rats: a comprehensive analysis from intestinal bacteria to metabolome and transcriptome.tif by Jiaxuan Liu (5185280)

“…</p>Results<p>SHTX treatment significantly altered the gut microbiota composition in T2DM rats, increasing the relative abundance of Bacteroidetes while decreasing that of Firmicutes, which was closely correlated with improved insulin sensitivity. …”

Data Sheet 1_Effect of Helicobacter pylori eradication on gastric cancer risk in patients with intestinal metaplasia or dysplasia: a meta-analysis of randomized controlled trials.d... by Qiang Fu (129583)

“…Further, if the study conducted in countries other than those in Asia, sample size <500, percentage of male <50.0%, follow-up duration <5.0 years, and low study quality, then there was no significant association between H. pylori eradication and a decreased risk of gastric cancer.…”