Functional Delivery Systems for Targeting Tumor Heterogeneity: Reversing Immunosuppression and Modulating Cancer-Immune Interplay by Di Han (618795)

“…By developing a delivery vector that specifically targets circulating malignant cells (CMCs) in patient blood samples, we established an ex vivo platform to study the dynamic interplay between patient-derived cancer cells and immune cells. …”

Functional Delivery Systems for Targeting Tumor Heterogeneity: Reversing Immunosuppression and Modulating Cancer-Immune Interplay by Di Han (618795)

“…By developing a delivery vector that specifically targets circulating malignant cells (CMCs) in patient blood samples, we established an ex vivo platform to study the dynamic interplay between patient-derived cancer cells and immune cells. …”

Image 1_Ketogenic diet–induced changes in methylation status and neuropeptide signaling: relationships between S-adenosylmethionine (AdoMet), orexin-A, and metabolic health.pdf by Laura Mosca (704904)

“…Circulating AdoMet (−75.7%) and Orexin-A (−7.2%) levels also decreased significantly. …”

Summary of KEGG enrichment analysis. by Zeynab Hosseinpoor (19762319)

“…While the expression levels of <i>IRS2</i>, <i>FOXO1</i>, and <i>ERK2</i> (<i>MAPK1</i>) were significantly decreased, the <i>SERPINF1</i> gene exhibited high expression simultaneously. pAAV-delivered <i>MIR-96</i> had no adverse effect on the viability of human RPE cells. …”

Descriptive statistics and estimated parameters of length-weight relationships (w = <i><i>a</i></i>L^<i>b</i>) for <i><i>E. erythropterus</i></i> before and after opening... by Jeong-Soo Gim (18058588)

iBAT characterization of the <i>aP2-Drp1</i>^f/f neonatal mice. by Yuta Ibayashi (20404811)

a Positive ion mode correlation heat map (A) Mild PTOA group VS Severe PTOA group (B) Mild PTOA group VS normal group (C) Severe PTOA group VS normal group. b. Negative ion mode co... by Peng-fei Han (694841)

PCA of bacterial communities. by Jun Sun (48981)

“…A significant positive correlation was observed between AK and both <i>Firmicutes</i> and <i>Kapabacteria</i> individually; furthermore, AP exhibited a highly significant positive correlation with <i>Kapabacteria</i> but a significant negative correlation with <i>unidentified Archaea</i>. …”

OUT Venn diagram. by Jun Sun (48981)

“…A significant positive correlation was observed between AK and both <i>Firmicutes</i> and <i>Kapabacteria</i> individually; furthermore, AP exhibited a highly significant positive correlation with <i>Kapabacteria</i> but a significant negative correlation with <i>unidentified Archaea</i>. …”

Histogram of the area factorψ. by Hong Zhang (25820)

“…The measured <i>I</i>_s decreases following a power-law trend as <i>β</i> and <i>D</i> increase, with weathering reducing the sensitivity of <i>I</i>_s to <i>β</i> but not significantly altering its sensitivity to <i>D</i>. …”

Raw dataset Fig. 6. by Hong Zhang (25820)

“…The measured <i>I</i>_s decreases following a power-law trend as <i>β</i> and <i>D</i> increase, with weathering reducing the sensitivity of <i>I</i>_s to <i>β</i> but not significantly altering its sensitivity to <i>D</i>. …”

Molecular dynamics simulation results for Apo-TP53 (red), wild-typeTP53. by Ashraf Attia Mahmoud (21262201)

Schematic for measuring <i>D</i> and <i>D</i>′ values. by Hong Zhang (25820)

“…The measured <i>I</i>_s decreases following a power-law trend as <i>β</i> and <i>D</i> increase, with weathering reducing the sensitivity of <i>I</i>_s to <i>β</i> but not significantly altering its sensitivity to <i>D</i>. …”

Primer sequences for RT-qPCR. by Wenlong Shen (9313937)

“…Data from TCGA showed that NCOA4 shows greater downgrade in tumor tissues than in non-tumor tissues and the overall survival (OS) of patients with low NCOA4 expression was significantly shorter than that of patients with high NCOA4 expression.The qPCR results showed that NCOA4 was expressed at low levels in cholangiocarcinoma tissue specimens; the mRNA expression of NCOA4 decreased after knocking down NCOA4 in cells. …”

siRNA sequences and negative controls sequences. by Wenlong Shen (9313937)

“…Data from TCGA showed that NCOA4 shows greater downgrade in tumor tissues than in non-tumor tissues and the overall survival (OS) of patients with low NCOA4 expression was significantly shorter than that of patients with high NCOA4 expression.The qPCR results showed that NCOA4 was expressed at low levels in cholangiocarcinoma tissue specimens; the mRNA expression of NCOA4 decreased after knocking down NCOA4 in cells. …”

Antibodies used in the study. by Wenlong Shen (9313937)

“…Data from TCGA showed that NCOA4 shows greater downgrade in tumor tissues than in non-tumor tissues and the overall survival (OS) of patients with low NCOA4 expression was significantly shorter than that of patients with high NCOA4 expression.The qPCR results showed that NCOA4 was expressed at low levels in cholangiocarcinoma tissue specimens; the mRNA expression of NCOA4 decreased after knocking down NCOA4 in cells. …”

(a) Data Acquisition System (b) Real time data collection. by Shaheer Ahmed Khan (17797647)

LEfSe analysis of root zone soil bacterium from different tea varieties. by Jun Sun (48981)

RDA and pearson correlation analysis of soil bacterial communities and soil environmental factors. by Jun Sun (48981)

Gentamicin treatment selects for surviving bacteria with reduced S10 expression in the mouse spleen. by Justin Greene (306625)