Discovery of an Orally Active PDE1 Inhibitor for Disease-Modifying Treatment of Postmenopausal Osteoporosis via Dual Anabolic-Antiresorptive Mechanisms by Farman M. Abbasi (22318766)

“…In ovariectomized mice, <b>5cc</b> administration (5 mg/kg) improved the trabecular microarchitecture, bone mineral density, and strength, at levels comparable to teriparatide, while significantly reducing bone resorption markers. With 13.57% oral bioavailability and selectivity for PDE1A1 (32% inhibition at 500 nM), <b>5cc</b> offers an innovative therapeutic candidate for PMO with a dual anabolic-antiresorptive profile and oral efficacy, warranting further clinical development.…”

Table 3_Ageing, clinical complexity, and exercise therapy: a multidimensional approach.docx by Salvatore Corrao (441339)

“…Ageing represents the primary risk factor for chronic degenerative diseases, especially involving cardiovascular, metabolic, respiratory, and osteoarticular systems, determining the decrease in activities and quality of daily life. Regular physical activity can significantly reduce the risk of chronic degenerative diseases, moderate or severe functional limitations, and premature death in older adults. …”

Table 1_Ageing, clinical complexity, and exercise therapy: a multidimensional approach.docx by Salvatore Corrao (441339)

“…Ageing represents the primary risk factor for chronic degenerative diseases, especially involving cardiovascular, metabolic, respiratory, and osteoarticular systems, determining the decrease in activities and quality of daily life. Regular physical activity can significantly reduce the risk of chronic degenerative diseases, moderate or severe functional limitations, and premature death in older adults. …”

Table 2_Ageing, clinical complexity, and exercise therapy: a multidimensional approach.docx by Salvatore Corrao (441339)

“…Ageing represents the primary risk factor for chronic degenerative diseases, especially involving cardiovascular, metabolic, respiratory, and osteoarticular systems, determining the decrease in activities and quality of daily life. Regular physical activity can significantly reduce the risk of chronic degenerative diseases, moderate or severe functional limitations, and premature death in older adults. …”

Infrared thermal images of typical subjects. by Yongliang Jiang (6200549)

“…Regarding the thermal characteristics, compared with the healthy control group, the temperature of the somatic sites of the heart meridian (Shenmen(HT7)/Shaohai(HT3)), as well as Taiyuan (LU9) of the lung meridian, increased significantly (<i><i>P</i></i> < 0.05). With regard to the metabolic features, rSO₂ of the somatic site of the heart meridian (Shaohai (HT3)) in the CSAP group decreased significantly (<i><i>P</i></i> < 0.05) as compared to the healthy control group. …”

The CONSORT flowchart of the study. by Yongliang Jiang (6200549)

“…Regarding the thermal characteristics, compared with the healthy control group, the temperature of the somatic sites of the heart meridian (Shenmen(HT7)/Shaohai(HT3)), as well as Taiyuan (LU9) of the lung meridian, increased significantly (<i><i>P</i></i> < 0.05). With regard to the metabolic features, rSO₂ of the somatic site of the heart meridian (Shaohai (HT3)) in the CSAP group decreased significantly (<i><i>P</i></i> < 0.05) as compared to the healthy control group. …”

Location of 4 somatic measurement sites. by Yongliang Jiang (6200549)

“…Regarding the thermal characteristics, compared with the healthy control group, the temperature of the somatic sites of the heart meridian (Shenmen(HT7)/Shaohai(HT3)), as well as Taiyuan (LU9) of the lung meridian, increased significantly (<i><i>P</i></i> < 0.05). With regard to the metabolic features, rSO₂ of the somatic site of the heart meridian (Shaohai (HT3)) in the CSAP group decreased significantly (<i><i>P</i></i> < 0.05) as compared to the healthy control group. …”

Minimal data set. by Yongliang Jiang (6200549)

“…Regarding the thermal characteristics, compared with the healthy control group, the temperature of the somatic sites of the heart meridian (Shenmen(HT7)/Shaohai(HT3)), as well as Taiyuan (LU9) of the lung meridian, increased significantly (<i><i>P</i></i> < 0.05). With regard to the metabolic features, rSO₂ of the somatic site of the heart meridian (Shaohai (HT3)) in the CSAP group decreased significantly (<i><i>P</i></i> < 0.05) as compared to the healthy control group. …”

Changes in intraocular pressure (IOP) from before to after omidenepag isopropyl administration in different patient groups. by Kana Tokumo (21702784)

“…<b>(b)</b> Comparison of IOP before and after omidenepag isopropyl in the new administration group. There was a significant decrease in IOP after starting the eye drops (<i>P</i> = 0.03, Wilcoxon signed-rank test).…”

Data Sheet 1_Platelet count and retinopathy of prematurity, a systematic review and meta-analysis.docx by Qian Zeng (2866592)

“…The pooled analysis indicated a significant decrease in mean platelet count among the ROP group compared to the non-ROP group (mean difference: −18.65, 95% confidence interval: −22.80 to −14.50, P < .00001). …”

A, B. Effects on explicit instruction about prospects of alternative goals on behavior. by Sneha Aenugu (21364349)

“…<p><b>A.</b> Task performance improves with instructions yet significantly falls short of the optimal prospective agent. …”

A protein-protein interaction (PPI) map of the paclitaxel associated DRG proteome. by Rania Hanna (18830411)

Data Sheet 1_Irrigation, variety, and year exert a greater influence on organic potato production than microbial inoculation: case study results of a 2-year on-farm experiment.docx by Orsolya Papp (18206269)

“…Concerning the effects of microbial inoculations, significant differences were observed only in plant stomatal conductance among all measured parameters: inoculation with T. asperelloides significantly decreased stomatal conductance in potato plants. …”

Table 1_Muscle quality index and hyperuricemia: adipose tissue as a mediator.docx by Ya Shao (16975896)

“…Each one-unit increment in MQI corresponded to a 50% decrease in the odds of hyperuricemia (OR: 0.50, 95% CI: 0.43–0.57). …”

Table 1_Effects of a community pharmacy-based structured medication review on drug-related problems in all-comers with polypharmacy: a randomized, controlled, double-blind, paralle... by Thorsten Bischof (19848696)

“…Furthermore, a medication review decreased the mean number of active ingredients by ~9% in the intervention group compared to the control group.…”

Citation patterns of Cochrane Reviews and other systematic reviews: a bibliometric analysis by Louise Olsbro Rosengaard (20439098)

“…The time window in which systematic reviews received citations has been progressively decreasing, possibly indicating a trend toward quicker recognition and uptake of these reviews within the academic community. …”

The Effect of Chronic Stress on Apoptosis Regulation and Oncogenesis Evolution: A Theoretical Approach. by DIMITRIOS KIMOGLOU (20499350)

“…In particular, we seek to illustrate the epigenetic influence of stress on genes that control apoptosis, as well as the significance of the HPA axis as a therapeutic target for restoring cellular equilibrium. …”

Structural equation model of potential predictors of maternal mental health of postpartum women during the COVID-19 pandemic in Argentina. by Agustín Ramiro Miranda (10399847)

Data Sheet 1_Pingers as a potential deterrent tool to mitigate Burmeister’s porpoise (Phocoena spinipinnis) bycatch while foraging nocturnally in the Humboldt Current System: a pil... by Diego Díaz (3286374)

“…For 27 days during austral summer, a full wave form capture porpoise detector was anchored 7 m above sea level in Mejillones Bay where Burmeister’s porpoises are frequently observed. …”

Supplementary file 1_Ivarmacitinib reduces the need for adding/escalating medications in moderate-to-severe rheumatoid arthritis patients: a post hoc analysis from a phase III tria... by Huaxiang Liu (322464)

“…</p>Conclusion<p>Ivarmacitinib significantly reduces the need for adding/escalating medications compared to placebo, thereby potentially decreasing treatment burden. …”