Data Sheet 1_Cellular effects of splenectomy on liver regeneration after 70% resection.pdf by Andrey Elchaninov (3122742)

“…According to high-throughput sequencing data, these cells express high levels of cell adhesion molecules. The spleen has a significant effect on liver regeneration through secretion of biologically active substances and migrating leukocytes. …”

Preeclamptic plasma disrupts endothelial function and promotes inflammation in endothelial cells: beneficial effects of glibenclamide and MCC950 in this scenario by Karoliny Nune Santos (21752603)

“…<p>Preeclampsia (PE) is characterized by systemic endothelial dysfunction and remains a significant clinical challenge. Activation of NLRP3 inflammasome, reactive oxygen species (ROS) production, and pyroptosis and autophagy are important mechanisms in this condition. …”

Data Sheet 1_Global burden of disease among adolescents and young adults with drug use disorders, 1990–2021: based on GBD 2021.doc by Ming Wang (172316)

“…Additionally, gender plays a significant role in the distribution of this burden, with males experiencing a higher burden than females. …”

Data Sheet 1_Global burden and trend of stroke attributable to metabolic risks among young adults (20–39 years old) from 1990 to 2021.docx by Qingguo Liu (9620123)

“…</p>Conclusions<p>Despite a decline in ASDR, the absolute burden of stroke attributable to metabolic risks among young adults has increased globally, with significant regional and national disparities. …”

Table 4_Antifungal mechanism and transcriptome analysis of Bacillomycin D-C16 against Fusarium oxysporum.xlsx by Fuxing Lin (7418234)

“…Furthermore, nearly all DEGs related to DNA replication were significantly suppressed. Biochemical assays confirmed these observations: Reduced activities of mitochondrial enzymes [malate dehydrogenase (MDH), isocitrate dehydrogenase (IDH), pyruvate dehydrogenase (PDH), and complexes I–V], decreased mitochondrial membrane potential, and diminished ATP content collectively indicated mitochondrial dysfunction. …”

Supplementary file 1_Exploration of the renoprotective effect of Yi-Shen-Hua-Shi granules on db/db mice and the mechanism of podocyte apoptosis based on the GRP78/CHOP signaling pa... by Yanmo Cai (22235563)

“…</p>Results<p>YSHS significantly improved the general status of db/db mice, with a significant reduction in body mass, renal function indices, total cholesterol, triglycerides, and low-density lipoprotein. …”

Table 1_Antifungal mechanism and transcriptome analysis of Bacillomycin D-C16 against Fusarium oxysporum.docx by Fuxing Lin (7418234)

“…Furthermore, nearly all DEGs related to DNA replication were significantly suppressed. Biochemical assays confirmed these observations: Reduced activities of mitochondrial enzymes [malate dehydrogenase (MDH), isocitrate dehydrogenase (IDH), pyruvate dehydrogenase (PDH), and complexes I–V], decreased mitochondrial membrane potential, and diminished ATP content collectively indicated mitochondrial dysfunction. …”

Table 2_The global burden of pediatric infective endocarditis (5–14 years): epidemiological patterns from 1990 to 2021 and projected trajectories.pdf by Ying Xiao (6517)

“…Background<p>Pediatric infective endocarditis (IE) remains a rare but life-threatening condition, with substantial morbidity and mortality among children worldwide. …”

DataSheet1_Effects of inulin-type oligosaccharides (JSO) from Cichorium intybus L. on behavioral deficits induced by chronic restraint stress in mice and associated molecular alter... by Caihong Yao (15344128)

“…Using a mouse model of chronic restraint stress (CRS), JSO was administered orally at doses of 50, 100, and 200 mg/kg for 21 days. …”

Data Sheet 1_Altered immune cell profiles in blood of mature/peripheral T-cell leukemia/lymphoma patients: an EuroFlow study.docx by F. Javier Morán-Plata (18986483)

“…Further dissection of the normal T-cell compartment showed a significant reduction of the earliest T-cell maturation compartments (N/CM) in T-PLL and SS/MF, whereas T-cells remained within normal ranges in T-LGLL, with only a minor reduction of N/CM T-cells.…”

Image 2_Antifungal mechanism and transcriptome analysis of Bacillomycin D-C16 against Fusarium oxysporum.tif by Fuxing Lin (7418234)

“…Furthermore, nearly all DEGs related to DNA replication were significantly suppressed. Biochemical assays confirmed these observations: Reduced activities of mitochondrial enzymes [malate dehydrogenase (MDH), isocitrate dehydrogenase (IDH), pyruvate dehydrogenase (PDH), and complexes I–V], decreased mitochondrial membrane potential, and diminished ATP content collectively indicated mitochondrial dysfunction. …”

Table 3_Antifungal mechanism and transcriptome analysis of Bacillomycin D-C16 against Fusarium oxysporum.xlsx by Fuxing Lin (7418234)

“…Furthermore, nearly all DEGs related to DNA replication were significantly suppressed. Biochemical assays confirmed these observations: Reduced activities of mitochondrial enzymes [malate dehydrogenase (MDH), isocitrate dehydrogenase (IDH), pyruvate dehydrogenase (PDH), and complexes I–V], decreased mitochondrial membrane potential, and diminished ATP content collectively indicated mitochondrial dysfunction. …”

Data Sheet 1_Association of cardiovascular health with COPD (NHANES 2007-2020): mediating potential of lean body mass.docx by Ruoyu Gou (11835929)

“…Background<p>Chronic Obstructive Pulmonary Disease (COPD) is a major global health concern, with lifestyle factors playing a crucial role in its prevention. …”

Table 1_Trend analysis of pediatric urolithiasis prevalence from 1990 to 2021 in the BRICS.docx by Zhi-gang Zhang (328212)

“…Encouragingly, the Age-Standardized Prevalence Rate (ASPR) has shown a decreasing trend. The disease burden of pediatric urolithiasis is higher in India and Russia, with the prevalence in India and ASPR in Russia being the highest in the BRICS countries. …”

Table 2_Antifungal mechanism and transcriptome analysis of Bacillomycin D-C16 against Fusarium oxysporum.docx by Fuxing Lin (7418234)

“…Furthermore, nearly all DEGs related to DNA replication were significantly suppressed. Biochemical assays confirmed these observations: Reduced activities of mitochondrial enzymes [malate dehydrogenase (MDH), isocitrate dehydrogenase (IDH), pyruvate dehydrogenase (PDH), and complexes I–V], decreased mitochondrial membrane potential, and diminished ATP content collectively indicated mitochondrial dysfunction. …”

Data Sheet 1_Celecoxib prevents malignant progression of smoking-induced lung tumors via suppression of the COX-2/PGE2 signaling pathway in mice.pdf by Kaori Sakurai (1272567)

“…Introduction<p>Lung cancer is characterized by a poor prognosis and is a significant comorbidity of chronic obstructive pulmonary disease (COPD). …”

Data Sheet 1_Impact of artificial intelligence on electronic health record-related burnouts among healthcare professionals: systematic review.pdf by Berna Sarraf (21651629)

“…Nevertheless, EHR-related workload has been considered as a significant contributor to healthcare professionals’ burnout, a syndrome associated with emotional exhaustion, depersonalization, and reduced personal accomplishment. …”

Table 7_Antifungal mechanism and transcriptome analysis of Bacillomycin D-C16 against Fusarium oxysporum.xlsx by Fuxing Lin (7418234)

“…Furthermore, nearly all DEGs related to DNA replication were significantly suppressed. Biochemical assays confirmed these observations: Reduced activities of mitochondrial enzymes [malate dehydrogenase (MDH), isocitrate dehydrogenase (IDH), pyruvate dehydrogenase (PDH), and complexes I–V], decreased mitochondrial membrane potential, and diminished ATP content collectively indicated mitochondrial dysfunction. …”

<i>Tmprss6</i> modulates radiation-induced liver injury through the hepcidin axis and PI3K/AKT pathway by Ya-Li Zhou (21696911)

“…<p>Radiation-induced liver injury (RILI) poses a significant challenge in abdomino-pelvic tumor radiotherapy, adversely impacting normal liver tissues. …”

Supplementary file 1_Bioinformatics analysis combined with experimental validation reveals the novel mechanisms of multi-targets of dapagliflozin attenuating diabetic liver injury.... by Pengyu Wang (6680312)

“…Dapagliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor, has shown significant therapeutic benefits in clinical trials for the management of diabetes However, the specific mechanism on the treatment of diabetic liver injury with dapagliflozin is not fully understood. …”