Novel Small-Molecule miR-124 Inducer Acts as “a Physiological Brake” of Inflammation in Ulcerative Colitis by Targeting the PIK3R2/PI3K/Akt Axis by Tiantian Wang (1688881)

“…This study identified FHND5032, a novel small-molecule miR-124 inducer, as a potent therapeutic candidate for UC. We found that FHND5032 significantly upregulated miR-124 expression in macrophages, surpassing the clinical-stage comparator ABX464 in vitro and in vivo. …”

Discovery of an Orally Active PDE1 Inhibitor for Disease-Modifying Treatment of Postmenopausal Osteoporosis via Dual Anabolic-Antiresorptive Mechanisms by Farman M. Abbasi (22318766)

“…Postmenopausal osteoporosis (PMO) is characterized by an imbalance in bone remodeling with increased osteoclast and decreased osteoblast activity, leading to bone loss and higher fracture risk. …”

Discovery of an Orally Active PDE1 Inhibitor for Disease-Modifying Treatment of Postmenopausal Osteoporosis via Dual Anabolic-Antiresorptive Mechanisms by Farman M. Abbasi (22318766)

“…Postmenopausal osteoporosis (PMO) is characterized by an imbalance in bone remodeling with increased osteoclast and decreased osteoblast activity, leading to bone loss and higher fracture risk. …”

Discovery of an Orally Active PDE1 Inhibitor for Disease-Modifying Treatment of Postmenopausal Osteoporosis via Dual Anabolic-Antiresorptive Mechanisms by Farman M. Abbasi (22318766)

“…Postmenopausal osteoporosis (PMO) is characterized by an imbalance in bone remodeling with increased osteoclast and decreased osteoblast activity, leading to bone loss and higher fracture risk. …”

Specifications of prototypes of RSSCA system. by Ngoc-Hai Vu (22290844)

“…Compared to conventional PV systems, the RSSCA offers improved light uniformity, better land-use efficiency, and significantly higher electricity generation. However, in regions with limited direct sunlight, such as Seoul in winter, system performance decreases. …”

S1 Data - by Jessica C. M. Hui (20370522)

“…Compared to the SD, the HFD and SDG models exhibited significantly increased and decreased contraction velocities and could be used as models of diarrhoea and constipation in DM, respectively, while the ED model showed comparatively little change in motility. …”

Design of a RSSCA system for agriculture. by Ngoc-Hai Vu (22290844)

“…Compared to conventional PV systems, the RSSCA offers improved light uniformity, better land-use efficiency, and significantly higher electricity generation. However, in regions with limited direct sunlight, such as Seoul in winter, system performance decreases. …”

pI7L suppresses the IFN-<i>γ</i>-triggered JAK-STAT signaling pathway. by Meilin Li (1832905)

pI7L inhibits the phosphorylation of STAT1 depending on its tyrosine at position 98. by Meilin Li (1832905)

Effect of O-ag modifying glycosyltransferases on complement activation and <i>Salmonella</i> interactions with human serum. by Fermin E. Guerra (6084545)

“…Statistical analysis was performed by one-way ANOVA on 3–4 biological replicates, with P values in red indicating statistical significance with P < 0.05. Column bars represent the means, with error bars displaying standard deviation. …”

O-ag length and composition impacts complement activation by <i>Salmonella</i> nontyphoidal and enteric fever serovars. by Fermin E. Guerra (6084545)

Modulating the Coordination Environment of Cu-Embedded Mo<i>X</i>₂ (<i>X</i> = S, Se, and Te) Monolayers for Electrocatalytic Reduction of CO₂ to CH<sub>4</su... by Thamarainathan Doulassiramane (17382128)

“…We found that the catalytic activity is mainly due to the level of antibonding states filling between the Cu atom and *OCHOH intermediate. …”

<i>S</i>. Paratyphi A has deficient L O-ag production due to R98C mutation in WzzB. by Fermin E. Guerra (6084545)

Reduction of L O-ag production and antigenic shift to O2-antigen in by Fermin E. Guerra (6084545)

“…Statistical analysis was performed by one-way ANOVA on 3–5 biological replicates, with P values in red indicating statistical significance with P < 0.05. Column bars represent the means, with error bars showing standard deviation. …”

Renal GRK4 knockdown impacted Mas receptor phosphorylation and Its-induced renal function in SHRs. by Lin Chen (54305)

The contribution of O-ag length and the Vi capsule to serum resistance is serovar dependent. by Fermin E. Guerra (6084545)

Box plot of queens and males in the young colony (left) and old colony (right) A-B compares the queens and males distribution in the young and old colonies, respectively. by Moïse Pierre Exélis (21578515)

Effects of bortezomib/venetoclax on the growth suppression of sLCL 381 xenografts in SCID mice. by Kam Pui Tam (19746865)

Structural equation model of potential predictors of maternal mental health of postpartum women during the COVID-19 pandemic in Argentina. by Agustín Ramiro Miranda (10399847)

Effect of preplant treatments on botrytis fruit rot (BFR) diseases during the 2022/23 and 2023/24 growing seasons. by Baker D. Aljawasim (22765921)