related to Fig 3. (A) Live eggs induce AIM2 pyroptosome formation. Microscopy of AIM2-citrine macrophages stimulated with live eggs for 48 h. by Madhusoodhanan Suresh Kumar Meena Kumari (20896666)

Comparison of sleep and activity the night before and after surgery in Experiment 1. by Akihiro Ohnishi (10989900)

Comparison of postoperative rest and activity between APS score groups in Experiment 2. by Akihiro Ohnishi (10989900)

Data for Fig 1. by Rachael M. Giersch (22331947)

“…We also observe a significant decrease in survival in animals that progress to >10% cancer in their hemolymph, while we see no effect on survival in clams with BTN that are long-term non-progressors. …”

NBs in Mod-depleted brains display defects in expression of key cell identity factors. by Amalia S. Parra (4173004)

Eggs jointly coordinate a caspase-1 and caspase-8 dependent pyroptotic cell death. by Madhusoodhanan Suresh Kumar Meena Kumari (20896666)

Blocking IFNAR leads to enhancement of IL-1β and IL-17 production. by Madhusoodhanan Suresh Kumar Meena Kumari (20896666)

related to Fig 4. ROS, K+ efflux and cathepsin B do not affect TNFα production in response to eggs. by Madhusoodhanan Suresh Kumar Meena Kumari (20896666)

Molecular docking showed that ABT-199 can fit into active site of ALK^Mutant. by Richard Junior Zapata Dongo (17912565)

Loss of Mod causes cell cycle defects. by Amalia S. Parra (4173004)

ROS, K⁺ efflux and cathepsin B are required for NLRP3 activation. by Madhusoodhanan Suresh Kumar Meena Kumari (20896666)

Ba/F3 EML4-ALK^mutants exhibit variable dose-response to ABT-199 treatment. by Richard Junior Zapata Dongo (17912565)

Mod loss is associated with a reduction of central brain NBs. by Amalia S. Parra (4173004)

The binding energy values of ATP, ALK inhibitors and ABT-199 to ALK were obtained from AlphaFold and modeled protein structures. by Richard Junior Zapata Dongo (17912565)

Anecdotal case of regression in a clam with naturally acquired BTN. by Rachael M. Giersch (22331947)

Negative (Prednisone) and basal (ATP) control compounds binding to ALK protein. by Richard Junior Zapata Dongo (17912565)

S1 Data - by Richard Junior Zapata Dongo (17912565)

“…This interaction was further supported by a significant decrease of ALK phosphorylation in single and combination treatment with 300nM ABT-199. …”

RNA targets of Mod identified by RiP-Seq. by Amalia S. Parra (4173004)

“…Mod is expressed in larval brains and its loss leads to a significant decrease in the number of central brain NBs. …”

The loss of NLRP3 and AIM2 results in reduced Th17 and enhanced Th2 cytokine responses. by Madhusoodhanan Suresh Kumar Meena Kumari (20896666)

Egg-induced IL-1β and IL-17 production is dependent on both Caspase-1 and Caspase-8. by Madhusoodhanan Suresh Kumar Meena Kumari (20896666)