Image2_Combined administration of catalpol, puerarin, gastrodin, and borneol modulates the Tlr4/Myd88/NF-κB signaling pathway and alleviates microglia inflammation in Alzheimer’s d... by Huijing Ren (19986303)

“…The results demonstrated that the combined administration of these 4 components (CPGB) had superior mitigating effects on AD cell model, as evidenced by the reduced pro-inflammatory cytokine production and decreased deposition of Aβ protein. Further in vivo and in vitro experiments confirmed that varying doses of CPGB formula effectively ameliorated STZ-induced cognitive deficits, as shown by NOR, MWM, and EMP tests, as well as pathological changes in hippocampal tissues and a 3-dimensional brain neurovascular unit (3D-NVU) model, including decreased deposition of Aβ protein and formation of plaques. …”

DataSheet1_Combined administration of catalpol, puerarin, gastrodin, and borneol modulates the Tlr4/Myd88/NF-κB signaling pathway and alleviates microglia inflammation in Alzheimer... by Huijing Ren (19986303)

“…The results demonstrated that the combined administration of these 4 components (CPGB) had superior mitigating effects on AD cell model, as evidenced by the reduced pro-inflammatory cytokine production and decreased deposition of Aβ protein. Further in vivo and in vitro experiments confirmed that varying doses of CPGB formula effectively ameliorated STZ-induced cognitive deficits, as shown by NOR, MWM, and EMP tests, as well as pathological changes in hippocampal tissues and a 3-dimensional brain neurovascular unit (3D-NVU) model, including decreased deposition of Aβ protein and formation of plaques. …”

Image1_Combined administration of catalpol, puerarin, gastrodin, and borneol modulates the Tlr4/Myd88/NF-κB signaling pathway and alleviates microglia inflammation in Alzheimer’s d... by Huijing Ren (19986303)

“…The results demonstrated that the combined administration of these 4 components (CPGB) had superior mitigating effects on AD cell model, as evidenced by the reduced pro-inflammatory cytokine production and decreased deposition of Aβ protein. Further in vivo and in vitro experiments confirmed that varying doses of CPGB formula effectively ameliorated STZ-induced cognitive deficits, as shown by NOR, MWM, and EMP tests, as well as pathological changes in hippocampal tissues and a 3-dimensional brain neurovascular unit (3D-NVU) model, including decreased deposition of Aβ protein and formation of plaques. …”

Methodology flow chart. by Sidra Aman Rana (14167473)

“…Moreover, the area of open land decreased significantly from 68.46% to 18.92%whereas the area under the built environment increased significantly from 7.77% to 36.51% from 1999—2019. …”

Image 1_Innate immune pathway activation to modulate mesenchymal stromal cell (MSC) interactions with synovium and cartilage.jpeg by Peter Linde (22011383)

“…Introduction<p>Mesenchymal stromal cells (MSCs) have been evaluated as a local therapeutic option to treat osteoarthritis (OA) with conflicting clinical results. …”

Protocol for our RNA-seq. by Sabih Rashid (5618807)

“…GO enrichment was conducted using the Wormbase Gene Set Enrichment Analysis [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3003144#pbio.3003144.ref046" target="_blank">46</a>,<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3003144#pbio.3003144.ref047" target="_blank">47</a>]. …”

Data Sheet 1_Wilt disease reshapes rhizosphere microbiota in small yellow ginger soils.docx by Qing Sun (492552)

“…</p>Results<p>Ginger wilt disease significantly altered the rhizosphere soil bacterial community structure and composition: the relative abundance of Proteobacteria increased significantly, primarily due to the enrichment of the genus Ralstonia; conversely, the relative abundance of Acidobacteriota, Firmicutes, and Chloroflexi significantly decreased. …”

Data Sheet 1_Differential regulation of soil microecology in crop rotation systems of maize, seed pumpkin, and processing tomato.docx by Xingxing Liu (715957)

“…Notably, the SLa treatment significantly decreased soil total potassium content by 13.6%. …”

TNC promotes bone regeneration via inflammatory macrophage by Qian Ren (19955367)

“…The cell communication analysis identifies ITGA7 as a TNC receptor contributing to the recruitment of inflammatory macrophages. …”

Table1_Seed priming with ascorbic acid and spermidine regulated auxin biosynthesis to promote root growth of rice under drought stress.docx by Kangkang Zhang (3367442)

“…The mitigating effects of AsA or Spd priming on drought stress were primarily responsible for decreasing the accumulation of reactive oxygen species by increasing antioxidants activities and osmoprotectants contents, which reduced oxidative stress and osmotic cell potential and facilitated improved water and nutrients absorption in roots. …”

DataSheet1_Dipeptide alanine-glutamine ameliorates retinal neurodegeneration in an STZ-induced rat model.docx by Yuhan Zhang (2792089)

“…Retinal levels of inflammatory factors were significantly decreased in Ala-Gln-treated diabetic rats. …”

Supplementary file 1_Synergistic effects of potassium and gibberellin on the yield and quality of yellow pitahaya (Hylocereus megalanthus) fruits in the Peruvian Amazon.docx by Julio Cesar Santos-Pelaez (22674113)

“…The combination of 100 kg K₂O ha⁻¹ and 50 mg L⁻¹ GA₃ significantly improved fruit performance, with fruit weight (369.5 g), yield (12 t ha⁻¹), volume (322 cm³), and soluble solids (22.8°Brix), while acidity decreased (pH 4.87 vs. 4.55 in the control). …”

Analytic framework. by Muayad Albadrani (7495145)

“…</p><p>Results</p><p>Logistic regression analysis revealed a strong negative association where household income increases and indoor air pollution-related mortality significantly decreases. …”

Descriptive statistics for the whole sample. by Muayad Albadrani (7495145)

“…</p><p>Results</p><p>Logistic regression analysis revealed a strong negative association where household income increases and indoor air pollution-related mortality significantly decreases. …”

Data Sheet 1_Transformation of polyacrylamide during hydrothermal carbonization and pyrolysis.docx by Gaoxiang Qi (1626193)

“…However, as the temperature exceeded 180 °C, the deamination process was significantly enhanced. Concurrently, the pH of the liquid phase decreased, which could be attributed to the decomposition of high molecular polybasic acids into low-molecular weight organic acids. …”

Scorpion venom cytolytic peptide Smp43 induces caspase-dependent apoptosis in ovarian carcinoma cell line OVCAR-3 by Salwa I. Hussein (22234753)

“…Additionally, Smp43 significantly increased DNA fragmentation in OVCAR-3 cells and decreased antioxidant parameters. …”

N-doped TiO₂ with stable surface Ti³⁺ for visible light photocatalytic hydrogen production by Jieming Chen (386865)

“…Experimental results indicate that reducing 1 g of TiO₂ with 0.2 g of NaBH₄, followed by calcination in an ammonia environment at 300℃, yields a catalyst with optimal visible-light photocatalytic hydrogen evolution activity, achieving a hydrogen production rate of 847.8 μmol h⁻¹ g⁻¹, representing a 177-fold enhancement over pristine anatase TiO₂. …”

Unlocking the synergy: Thermochemical behavior and kinetics in the co-combustion of coal gangue and wheat straw by Yanshan Yin (4800234)

“…This study investigates the co-combustion behavior of CG, WS, and their mixtures at five different ratios using a thermogravimetric analyzer (TGA). The results reveal that the addition of WS significantly lowers both the ignition and burnout temperatures of CG. …”

Data Sheet 1_Potential cerebrospinal fluid metabolomic biomarkers and early prediction model for Parkinson’s disease.docx by Yifan Zhang (119570)

“…A bidirectional causal relationship exists between genetically determined PD susceptibility and metabolites.…”

<b>Human Milk Oligosaccharides Mitigate Infant </b><b>Diarrhea</b><b> </b><b>and </b><b>Anxiety</b><b>-like </b><b>Behaviors</b><b> via Gut Microbiota Modulation in an EPEC O127 In... by wang wenxiu (21257327)

“…The results showed that HMOs significantly alleviated diarrhea symptoms, mitigated anxiety-like behaviors, reduced colon inflammation, and <a href="" target="_blank">restored gut barrier integrity</a>. …”