Data Sheet 1_Dual variants of uncertain significance in a case of hyper-IgM syndrome: implications for diagnosis and management.pdf by Nourhen Agrebi (14151222)

“…</p>Objective<p>This study aims to elucidate the clinical implications of concurrent AICDA and IKBKB homozygous variants in a pediatric patient diagnosed with hyper-IgM syndrome.</p>Methods<p>We present immunological and genetic analysis of a Tunisian patient with two homozygous variants of uncertain significance (VUSs) in the IKBKB and AICDA genes, suspected of causing hyper-IgM and immune deficiency. …”

Data Sheet 1_Case report: Significant lesion reduction and neural structural changes following ibogaine treatments for multiple sclerosis.docx by David Qixiang Chen (8198265)

“…Ibogaine, a psychoactive alkaloid, has been proposed as a potential neuroregenerative agent due to its multifaceted pharmacological profile. We present two case studies of MS patients who underwent a novel ibogaine treatment, highlighting significant neuroimaging changes and clinical improvements. …”

Data Sheet 2_Case report: Significant lesion reduction and neural structural changes following ibogaine treatments for multiple sclerosis.docx by David Qixiang Chen (8198265)

“…Ibogaine, a psychoactive alkaloid, has been proposed as a potential neuroregenerative agent due to its multifaceted pharmacological profile. We present two case studies of MS patients who underwent a novel ibogaine treatment, highlighting significant neuroimaging changes and clinical improvements. …”

Data Sheet 3_Case report: Significant lesion reduction and neural structural changes following ibogaine treatments for multiple sclerosis.docx by David Qixiang Chen (8198265)

“…Ibogaine, a psychoactive alkaloid, has been proposed as a potential neuroregenerative agent due to its multifaceted pharmacological profile. We present two case studies of MS patients who underwent a novel ibogaine treatment, highlighting significant neuroimaging changes and clinical improvements. …”

Image 2_The anti-depressive role of the Pei Yuan Kai Yu formula in cerebral small vessel disease based on gut microbiota.tif by Lixuan Yang (7331786)

“…</p>Results<p>In rats with CSVD and depression, PY significantly increased body weight; alleviated depression-like behaviors; and decreased the levels of inflammatory cytokines such as TNF-α, IL-1β, and IL-6 in both serum and hippocampus. …”

Image 1_The anti-depressive role of the Pei Yuan Kai Yu formula in cerebral small vessel disease based on gut microbiota.tif by Lixuan Yang (7331786)

“…</p>Results<p>In rats with CSVD and depression, PY significantly increased body weight; alleviated depression-like behaviors; and decreased the levels of inflammatory cytokines such as TNF-α, IL-1β, and IL-6 in both serum and hippocampus. …”

Multiproxy summary of pollen, fecal biomarker, and charcoal data for BF19. by John A. F. Wendt (19976392)

Ungulate community dynamics and associated environmental variables at Buffalo Ford Lake and the lower Lamar Valley during the last <i>c</i>. 2300 years. by John A. F. Wendt (19976392)

qPCR primer sequences. by Shuaini Yang (20670608)

“…<div><p>CCR2, a member of the G protein-coupled receptor (GPCR) superfamily, is widely expressed on monocytes, macrophages, activated T cells, and other cell types, and plays a critical role in coordinating the immune response to various infections. Here we demonstrate that CCR2 expression is significantly elevated during Chlamydia muridarum (<i>C</i>. …”

Benchmark regression results. by Pengyu Yang (2668450)

“…The findings reveal that: (1) At this stage, digital transformation in listed companies effectively reduces their carbon intensity, but the relationship between the two is not linear; instead, it exhibits a U-shaped trajectory, initially decreasing then increasing. (2) Analysis of mechanism indicates that costs associated with environmental governance and innovations in green technology serve as critical pathways through which corporate digital transformation influences carbon intensity. (3) The analysis of driving effect suggests that the digital transformation significantly curtails the carbon emission intensity of both upstream and downstream enterprises as well as those within the same industry and geographical region, through industrial linkage and the cohort effect. (4) Heterogeneity analysis elucidates that the digital transformation of enterprises in regions with stronger government environmental regulations has a markedly more pronounced effect on reducing the carbon emission intensity. …”

Heterogeneity test. by Pengyu Yang (2668450)

“…The findings reveal that: (1) At this stage, digital transformation in listed companies effectively reduces their carbon intensity, but the relationship between the two is not linear; instead, it exhibits a U-shaped trajectory, initially decreasing then increasing. (2) Analysis of mechanism indicates that costs associated with environmental governance and innovations in green technology serve as critical pathways through which corporate digital transformation influences carbon intensity. (3) The analysis of driving effect suggests that the digital transformation significantly curtails the carbon emission intensity of both upstream and downstream enterprises as well as those within the same industry and geographical region, through industrial linkage and the cohort effect. (4) Heterogeneity analysis elucidates that the digital transformation of enterprises in regions with stronger government environmental regulations has a markedly more pronounced effect on reducing the carbon emission intensity. …”

S1 File - by Pengyu Yang (2668450)

“…The findings reveal that: (1) At this stage, digital transformation in listed companies effectively reduces their carbon intensity, but the relationship between the two is not linear; instead, it exhibits a U-shaped trajectory, initially decreasing then increasing. (2) Analysis of mechanism indicates that costs associated with environmental governance and innovations in green technology serve as critical pathways through which corporate digital transformation influences carbon intensity. (3) The analysis of driving effect suggests that the digital transformation significantly curtails the carbon emission intensity of both upstream and downstream enterprises as well as those within the same industry and geographical region, through industrial linkage and the cohort effect. (4) Heterogeneity analysis elucidates that the digital transformation of enterprises in regions with stronger government environmental regulations has a markedly more pronounced effect on reducing the carbon emission intensity. …”

The robustness test. by Pengyu Yang (2668450)

“…The findings reveal that: (1) At this stage, digital transformation in listed companies effectively reduces their carbon intensity, but the relationship between the two is not linear; instead, it exhibits a U-shaped trajectory, initially decreasing then increasing. (2) Analysis of mechanism indicates that costs associated with environmental governance and innovations in green technology serve as critical pathways through which corporate digital transformation influences carbon intensity. (3) The analysis of driving effect suggests that the digital transformation significantly curtails the carbon emission intensity of both upstream and downstream enterprises as well as those within the same industry and geographical region, through industrial linkage and the cohort effect. (4) Heterogeneity analysis elucidates that the digital transformation of enterprises in regions with stronger government environmental regulations has a markedly more pronounced effect on reducing the carbon emission intensity. …”

Mechanistic testing. by Pengyu Yang (2668450)

“…The findings reveal that: (1) At this stage, digital transformation in listed companies effectively reduces their carbon intensity, but the relationship between the two is not linear; instead, it exhibits a U-shaped trajectory, initially decreasing then increasing. (2) Analysis of mechanism indicates that costs associated with environmental governance and innovations in green technology serve as critical pathways through which corporate digital transformation influences carbon intensity. (3) The analysis of driving effect suggests that the digital transformation significantly curtails the carbon emission intensity of both upstream and downstream enterprises as well as those within the same industry and geographical region, through industrial linkage and the cohort effect. (4) Heterogeneity analysis elucidates that the digital transformation of enterprises in regions with stronger government environmental regulations has a markedly more pronounced effect on reducing the carbon emission intensity. …”

Descriptive statistics of variables. by Pengyu Yang (2668450)

“…The findings reveal that: (1) At this stage, digital transformation in listed companies effectively reduces their carbon intensity, but the relationship between the two is not linear; instead, it exhibits a U-shaped trajectory, initially decreasing then increasing. (2) Analysis of mechanism indicates that costs associated with environmental governance and innovations in green technology serve as critical pathways through which corporate digital transformation influences carbon intensity. (3) The analysis of driving effect suggests that the digital transformation significantly curtails the carbon emission intensity of both upstream and downstream enterprises as well as those within the same industry and geographical region, through industrial linkage and the cohort effect. (4) Heterogeneity analysis elucidates that the digital transformation of enterprises in regions with stronger government environmental regulations has a markedly more pronounced effect on reducing the carbon emission intensity. …”

Endogenous treatment. by Pengyu Yang (2668450)

“…The findings reveal that: (1) At this stage, digital transformation in listed companies effectively reduces their carbon intensity, but the relationship between the two is not linear; instead, it exhibits a U-shaped trajectory, initially decreasing then increasing. (2) Analysis of mechanism indicates that costs associated with environmental governance and innovations in green technology serve as critical pathways through which corporate digital transformation influences carbon intensity. (3) The analysis of driving effect suggests that the digital transformation significantly curtails the carbon emission intensity of both upstream and downstream enterprises as well as those within the same industry and geographical region, through industrial linkage and the cohort effect. (4) Heterogeneity analysis elucidates that the digital transformation of enterprises in regions with stronger government environmental regulations has a markedly more pronounced effect on reducing the carbon emission intensity. …”

Analysis of industry linkage effects. by Pengyu Yang (2668450)

“…The findings reveal that: (1) At this stage, digital transformation in listed companies effectively reduces their carbon intensity, but the relationship between the two is not linear; instead, it exhibits a U-shaped trajectory, initially decreasing then increasing. (2) Analysis of mechanism indicates that costs associated with environmental governance and innovations in green technology serve as critical pathways through which corporate digital transformation influences carbon intensity. (3) The analysis of driving effect suggests that the digital transformation significantly curtails the carbon emission intensity of both upstream and downstream enterprises as well as those within the same industry and geographical region, through industrial linkage and the cohort effect. (4) Heterogeneity analysis elucidates that the digital transformation of enterprises in regions with stronger government environmental regulations has a markedly more pronounced effect on reducing the carbon emission intensity. …”

Analysis of peer effects. by Pengyu Yang (2668450)

“…The findings reveal that: (1) At this stage, digital transformation in listed companies effectively reduces their carbon intensity, but the relationship between the two is not linear; instead, it exhibits a U-shaped trajectory, initially decreasing then increasing. (2) Analysis of mechanism indicates that costs associated with environmental governance and innovations in green technology serve as critical pathways through which corporate digital transformation influences carbon intensity. (3) The analysis of driving effect suggests that the digital transformation significantly curtails the carbon emission intensity of both upstream and downstream enterprises as well as those within the same industry and geographical region, through industrial linkage and the cohort effect. (4) Heterogeneity analysis elucidates that the digital transformation of enterprises in regions with stronger government environmental regulations has a markedly more pronounced effect on reducing the carbon emission intensity. …”

Table 1_The knowledge paradox: an inverted U-shaped association between HIV knowledge and stigma among older men in Sichuan Province, Southwest China.docx by Zhihua Ye (3133311)

“…Regression analysis revealed an inverted U-shaped association. Stigma initially increased with increasing knowledge (linear β = 1.71, p < 0.001), peaked at a knowledge score of 4.14, and subsequently decreased with increasing knowledge gain (quadratic β = −0.21, p < 0.001). …”

Data for Fig 1. by Rachael M. Giersch (22331947)

“…We also observe a significant decrease in survival in animals that progress to >10% cancer in their hemolymph, while we see no effect on survival in clams with BTN that are long-term non-progressors. …”