Synthesis and Biological Evaluation of MEK/mTOR Multifunctional Inhibitors as Novel Anticancer Agents by Marcian E. Van Dort (21374093)

“…Additionally, compound LP-65 demonstrated significant modulation of MEK and mTOR signaling activity in human glioma cells (D54) and human melanoma cells (A375), with a corresponding decrease in cellular proliferation and migration. …”

Coal seam combustion (a), (c) and infrared thermometry map (b), (d) in Fire Zone 1 and 3 (Republished from Desheng Xie under a CC BY license, with permission from Desheng Xie, orig... by Desheng Xie (21439869)

The restoration effect carried out in the early stage of (a) Fire Zone 1 and (b) Fire Zone 3 (Republished from Desheng Xie under a CC BY license, with permission from Desheng Xie,... by Desheng Xie (21439869)

Image1_Association between mental health and male fertility: depression, rather than anxiety, is linked to decreased semen quality.tif by Yi Zhang (9093)

“…Furthermore, when stratified by sleep duration, moderate to severe depression group showed a great decrease in progressive motility (PR), total motility, concentration and total sperm count (TSC) as referred to normal group in participants with sleep duration less than 7 hours.…”

Multivariable logistic regression analysis of the relationship of the date of a PHC visit with new visits, types of health events, procedure, and outcome of visits. by Taizo Sakata (21567847)

<b>The loss of insulin-positive cell clusters precedes the decrease of islet frequency and beta cell area in type 1 diabetes</b> by Denise M. Drotar (21679539)

“…Moreover, changes in endocrine composition also occurred in mAAb+ donors, including a significant decrease in the INS+ islet fraction. …”

Data Sheet 1_The “best practices for farming” successfully contributed to decrease the antibiotic resistance gene abundances within dairy farms.docx by Barbara Salerno (12894908)

“…Despite similar levels of antibiotic administration (based on veterinary prescription data from the sampled farms) in both sampling campaigns, the total abundance of selected ARGs, particularly bla_TEM and tetA, significantly decreased after the adoption of the farming guidelines.…”

LncRNA <i>C5orf64</i> polymorphisms (rs12518552 and rs2950218) decreases pulmonary tuberculosis susceptibility by Shilin Xu (1884217)

Data Sheet 1_Decreased brain-derived neurotrophic factor expression in chronic kidney disease: integrated clinical and experimental evidence.docx by Juan Chen (61123)

“…</p>Conclusion<p>This study integrated meta-analysis, murine model validation, and single-cell transcriptomic profiling to demonstrate a significant reduction of BDNF in CKD. Furthermore, renal BDNF expression decreased locally, predominantly originating from proximal tubule cells, macrophages, and podocytes, possibly epigenetically inhibited by the upregulation of lnc RNA Bdnf-as.…”

The normal force between two particles with different equivalent diameters for P3: (a) hertznormal contact force; (b) normal viscous contact force. by Yongfeng Zhu (7361045)

Chromatograms proved the selectivity of the proposed method. Red line: tissue spiked at the LOQ level; green line: blank tissue. Panel A: SIM and SIMA; panel B: LOV and LOVA. by Ewa Paszkowska (21246702)

A brief illustration of the revisions between AJCC TNM eighth and ninth editions. by Aihong Zheng (20571034)

Image 2_Hemoglobin glycation index and all-cause mortality in adults: insights from a decade-long prospective cohort study.tif by Yue-Yang Zhang (14258160)

“…</p>Core tip<p>The aim of this study was to assess the association of Hemoglobin Glycation Index(HGI) with all-cause mortality in non-type 2 diabetic patients based on a 10-year cohort study from China. After COX regression, restricted cubic spline analysis, and subgroup analyses, it was found that a significant increase or decrease in HGI adversely affected long-term survival.…”

Image 1_Hemoglobin glycation index and all-cause mortality in adults: insights from a decade-long prospective cohort study.tif by Yue-Yang Zhang (14258160)

“…</p>Core tip<p>The aim of this study was to assess the association of Hemoglobin Glycation Index(HGI) with all-cause mortality in non-type 2 diabetic patients based on a 10-year cohort study from China. After COX regression, restricted cubic spline analysis, and subgroup analyses, it was found that a significant increase or decrease in HGI adversely affected long-term survival.…”

(a, b). The statistical error analyses for the models using the same dataset. by Fahd Saeed Alakbari (10701871)

Study selection criteria. by Filip Stanicic (17808254)

“…Durability was observed in a long-term follow-up trial (mean duration, 45.4 months) with a 0.9-point CAPS decrease from post-treatment.…”

PICOS criteria for the SLR. by Filip Stanicic (17808254)

“…Durability was observed in a long-term follow-up trial (mean duration, 45.4 months) with a 0.9-point CAPS decrease from post-treatment.…”

PRISMA flow chart. by Filip Stanicic (17808254)

“…Durability was observed in a long-term follow-up trial (mean duration, 45.4 months) with a 0.9-point CAPS decrease from post-treatment.…”

Table1_Metabolic dysregulation and decreased capillarization in skeletal muscles of male adolescent offspring rats exposed to gestational intermittent hypoxia.docx by Wirongrong Wongkitikamjorn (14394162)

“…Furthermore, gene expression of adiponectin receptors one and two was significantly decreased in the DIA and TA muscles. In addition, the DIA muscle from adolescent rats had significantly decreased capillary density as a result of gestational IH. …”

Image2_Metabolic dysregulation and decreased capillarization in skeletal muscles of male adolescent offspring rats exposed to gestational intermittent hypoxia.JPEG by Wirongrong Wongkitikamjorn (14394162)

“…Furthermore, gene expression of adiponectin receptors one and two was significantly decreased in the DIA and TA muscles. In addition, the DIA muscle from adolescent rats had significantly decreased capillary density as a result of gestational IH. …”