Data Sheet 1_Galangin ameliorates PTU-induced vitiligo in zebrafish and B16F10 cells by increasing melanogenesis through activation of the p38/JNK MAPK pathway.pdf by Zulipikaer Wusiman (20852138)

“…In addition, transcriptome analysis indicated that GA likely acts through the mitogen-activated protein kinase (MAPK) signaling pathway. GA has a strong binding affinity for important targets.GA significantly increased the expression of genes such as mapk8b, mapk14a, mapk3, mitf, tyr, tyrp1b, tyrp1a, dct, and oca2, and decreased the expression of genes such as expression of genes such as raf1 and egfr. …”

DataSheet1_Synergistic combinations of Angelica sinensis for myocardial infarction treatment: network pharmacology and quadratic optimization approach.docx by Wen-Di Wang (20400446)

“…Further research revealed that Z-LIG/CGA treatment significantly increased IL-1R2 levels, significantly decreased IL-17RA levels, and inhibited the activation of p-STAT1, thereby alleviating cell apoptosis after MI. …”

<b>Mystery of Deep Soil Organic Carbon Dynamics Uncovered through Long-term Conservation Tillage Experiments</b> by Jianye Li (8914520)

“…</a> Plant-derived carbon showed increased stability in the deep soil, as evidenced by decreased (Ac/Al)s values (-58%) and (Ac/Al)v values (-28%) and a 84% rise in V-type phenols under NT. …”

Supplementary file 1_First exposure to second-generation antipsychotics alters gut microbiota and metabolic profiles in patients with glucose-lipid metabolism disorders.docx by Yuexia Wu (10755903)

“…Metabolomic analysis revealed decreased levels of oleamide and stearamide in the post-medication group, which exhibited a negative correlation with the abundance of Faecalibacterium. …”

Supplementary Material for: Exploring the ability of novel choroidal biomarkers in predicting treatment outcomes of polypoidal choroidal vasculopathy by Zhang Y. (2828780)

“…The greater change of central macular thickness (CMT) was significantly correlated with increased CMT (P=0.030), decreased CT (P=0.042) and decreased CVI (p=0.038) at baseline. …”

Table 1_Effects of compound yeast culture on growth performance, antioxidant function and inflammatory factors of Hu sheep.docx by Shixiong Liu (610750)

“…The serum total antioxidant capacity (T-AOC) content and superoxide dismutase activity (SOD) activity of Hu sheep in the experimental group significantly increased (p < 0.05). The malondialdehyde (MDA) content decreased significantly (p < 0.01). …”

Coconut shell activated carbon (CSAC) reinforced municipal sludge by high pressurized electro-dewatering with constant voltage gradient by Binqi Rao (22300677)

“…The results indicated that under a constant voltage gradient of 36 V/cm, the moisture content (<i>M_c</i>) of sludge significantly decreased from 88% to 64%, and there was a noticeable improvement in the resistance and temperature of sludge cake compared to the constant voltage mode. …”

Focused operations to improve the patient flow in full-service healthcare organisations by Philip Åhlin (15257749)

“…Our findings reveal that blending simple and complex care processes lowers flow efficiency while segmenting them into either high-volume, low-variety (focused) and low-volume, high-variety (general) significantly improves productivity. Our framework serves as a tool for healthcare managers to define strategic directions, evaluate operational focus, and implement streamlined operations. …”

Table 1_Anemoside B4 targets RAGE to attenuate ferroptosis in sepsis-induced acute lung injury.xlsx by Yue Bu (11357379)

“…</p>Results<p>AB4 ameliorated CLP-induced lung injury in mice, as evidenced by reduced pathological damage, lower injury scores, and a decreased lung wet-to-dry weight ratio. In vivo, AB4 significantly reduced levels of pro-inflammatory cytokines (IL-1β, TNF-α, and IL-6), decreased oxidative stress markers MDA and DHE, and increased GSH levels. …”

Table 2_Anemoside B4 targets RAGE to attenuate ferroptosis in sepsis-induced acute lung injury.xlsx by Yue Bu (11357379)

“…</p>Results<p>AB4 ameliorated CLP-induced lung injury in mice, as evidenced by reduced pathological damage, lower injury scores, and a decreased lung wet-to-dry weight ratio. In vivo, AB4 significantly reduced levels of pro-inflammatory cytokines (IL-1β, TNF-α, and IL-6), decreased oxidative stress markers MDA and DHE, and increased GSH levels. …”

Table 3_Anemoside B4 targets RAGE to attenuate ferroptosis in sepsis-induced acute lung injury.docx by Yue Bu (11357379)

“…</p>Results<p>AB4 ameliorated CLP-induced lung injury in mice, as evidenced by reduced pathological damage, lower injury scores, and a decreased lung wet-to-dry weight ratio. In vivo, AB4 significantly reduced levels of pro-inflammatory cytokines (IL-1β, TNF-α, and IL-6), decreased oxidative stress markers MDA and DHE, and increased GSH levels. …”

Table 1_Early detection of retinal and choroidal microvascular impairments in diabetic patients with myopia.docx by Yufei Wu (3625967)

“…The AI-driven analysis revealed that decreased CVI and CT were significantly associated with age and spherical equivalent (SE), highlighting the utility of automated algorithms in identifying early microvascular impairments.…”

Changes to the host transcriptome during infection. by Stefan Bresson (20623940)

“…The heatmap shows the most significantly decreased transcripts (by <i>p</i>-value). …”

GnRH antagonist impairs the process of embryo implantation by inhibiting motility of endometrial stromal cells through reducing c-kit expression by Jun Tan (46388)

“…Moreover, we also found a decreased expression and phosphorylation of c-kit receptor in decidualized hESCs after treating with GnRH-ant. …”

Data Sheet 2_Preventive hyperbaric oxygen therapy improves acute graft-versus-host disease by activating the Nrf2/HO-1 pathway.docx by Chao Xue (503328)

“…</p>Results<p>We found that HBOT alleviated aGVHD in mice, which was associated with a significantly prolonged overall survival (OS) and reduced pathological injury, whereas Nrf2 inhibition had the opposite effect. …”

Data Sheet 1_Preventive hyperbaric oxygen therapy improves acute graft-versus-host disease by activating the Nrf2/HO-1 pathway.pdf by Chao Xue (503328)

“…</p>Results<p>We found that HBOT alleviated aGVHD in mice, which was associated with a significantly prolonged overall survival (OS) and reduced pathological injury, whereas Nrf2 inhibition had the opposite effect. …”

Susceptibility of RUNX1 promoter rs2071029 polymorphism to adjuvant chemotherapy-induced neutropenia in CRC by Xikai Luo (21520875)

“…RUNX1 promoter SNP rs2071029T had a decreased risk of severe CIN compared with rs2071029C. …”

Supplementary data.xlsx by Danjun Li (21443051)

“…<p dir="ltr">Telomere length(TL) is important for the maintaining the individual health of a species. However, recent studies have indicated that the telomere length of somatic cells can be drastically decreased in the offspring receiving in vitrofertilization (IVF) therapy, however, the underlying molecular mechanism remains unknown. …”

Supplementary Material for: Retrospective Analysis of Allergen Characteristics in Patients with Allergic Diseases in Sanmen, Zhejiang Province by figshare admin karger (2628495)

“…The serum total IgE positivity rate was highest in the ≤12 age group and declined with age, with a resurgence observed in individuals over 60. Similarly, the positivity rates for Dermatophagoides spp. allergens and cow's milk also decreased with age. …”

Beta Diversity and Differential Abundance Analysis of Gut Microbiota after FVT. by Melany Cervantes-Echeverría (22794116)

“…The blue bars indicate taxa significantly increased, while the red bars indicate taxa significantly decreased in the FVT compared to the control. …”