DataSheet1_FOXO1-mediated autophagy regulation by miR-223 in sepsis-induced immunosuppression.ZIP حسب Guoan Xiang (383282)

"…Levels of autophagy were monitored using a double-labeled lentivirus (mRFP-GFP-LC3) and electron microscopy, and western blot analysis was used to estimate the levels of autophagy-related proteins and FOXO1 in the two cell models after co-treatment with lipopolysaccharide (LPS) and siRNA against FOXO1.</p>Results<p>We found that when the expression of miR-223 increased, FOXO1 expression decreased and autophagy decreased; whereas, when FOXO1 expression was inhibited, autophagy decreased significantly in different cell models after LPS induction.…"

Glia-targeted 5-HT_2A receptor expression in adults reopens experience-dependent synaptic glomeruli pruning. حسب Vanessa Kay Miller (19775496)

"…All the individual data points are shown with the mean ± SEM. Significance is indicated as <i>p</i> < 0.0001 (****) and <i>p</i> > 0.05 (not significant, ns). …"

Video 2_Efficacy of P62-expressing plasmid in treatment of canine osteoarthritis pain: a pilot study.mp4 حسب Vladimir Gabai (38129)

"…Improvement in CBPI was observed after 2–4 weeks of treatment, whereas after 5–6 weeks of the treatment the parameters reached the plateau. After 10 weeks mean PSS score after the treatment decreased from 5.25 to 3.25, PIS score - from 7.0 to 3.27, and number of dogs with excellent and good QoL due to treatment increased from 1 to 12. …"

Video 3_Efficacy of P62-expressing plasmid in treatment of canine osteoarthritis pain: a pilot study.mp4 حسب Vladimir Gabai (38129)

"…Improvement in CBPI was observed after 2–4 weeks of treatment, whereas after 5–6 weeks of the treatment the parameters reached the plateau. After 10 weeks mean PSS score after the treatment decreased from 5.25 to 3.25, PIS score - from 7.0 to 3.27, and number of dogs with excellent and good QoL due to treatment increased from 1 to 12. …"

Video 1_Efficacy of P62-expressing plasmid in treatment of canine osteoarthritis pain: a pilot study.mp4 حسب Vladimir Gabai (38129)

"…Improvement in CBPI was observed after 2–4 weeks of treatment, whereas after 5–6 weeks of the treatment the parameters reached the plateau. After 10 weeks mean PSS score after the treatment decreased from 5.25 to 3.25, PIS score - from 7.0 to 3.27, and number of dogs with excellent and good QoL due to treatment increased from 1 to 12. …"

Figure 5 from Membrane-bound Heat Shock Protein mHsp70 Is Required for Migration and Invasion of Brain Tumors حسب Maxim Shevtsov (15023874)

"…<p>Application of Hsp70 inhibitors decreases the brain tumor cell migratory activity. …"

Image 1_Cannabis use is associated with alterations in NLRP3 inflammasome related gene expression in monocyte-derived macrophages from people living with HIV.tif حسب Kyle C. Walter (22578179)

"…When treated with CBD and IL-1β, we observed a significant increase in both IL1β (3-fold, p < 0.01) and IL18 (2-fold, p < 0.01) expression compared to vehicle. …"

Clinical and biochemical determinants of length of stay, readmission and recurrence in patients admitted with diabetic ketoacidosis حسب Fateen Ata (12217764)

"…<p>The increasing prevalence of diabetic ketoacidosis (DKA) related admissions poses a significant burden on the healthcare systems globally. …"

Data_Sheet_1_Subthreshold amyloid deposition, cerebral small vessel disease, and functional brain network disruption in delayed cognitive decline after stroke.docx حسب Jae-Sung Lim (532986)

"…</p>Methods<p>Using a prospective stroke registry, we identified patients who displayed normal cognitive function at baseline evaluation within a year post-stroke and received at least one subsequent assessment. …"

Data Sheet 1_Short-term structured dietary and exercise interventions delay diabetes onset in prediabetic patients: a prospective quasi-experimental study.pdf حسب Zhen Wang (72451)

"…The mean survival time before diabetes onset was significantly longer in prediabetic patients who received SAIDEs than in those in other groups.…"

Data Sheet 2_A novel molecule targeting neutrophil-mediated B-1a cell trogocytosis attenuates sepsis-induced acute lung injury.pdf حسب Yuichi Akama (17892940)

"…Our data showed that B-1a cell numbers and frequencies in the pleural and peritoneal cavities were significantly decreased in sepsis. Neutrophils co-cultured with B-1a cells significantly increased B-1a cell internalization via trogocytosis. …"

Data Sheet 1_A novel molecule targeting neutrophil-mediated B-1a cell trogocytosis attenuates sepsis-induced acute lung injury.pdf حسب Yuichi Akama (17892940)

"…Our data showed that B-1a cell numbers and frequencies in the pleural and peritoneal cavities were significantly decreased in sepsis. Neutrophils co-cultured with B-1a cells significantly increased B-1a cell internalization via trogocytosis. …"

Assessment of calcium events, pERK levels, NMDA receptor expression and extracellular zinc levels in <i>slc13a5</i> mutants. حسب Deepika Dogra (21072023)

"…Untreated WTs, n = 4; DMSO-treated WTs, n = 3. Data are Mean ±  S.E.M., ns: no significant changes observed, * P ≤  0.05, **P ≤  0.01, ***P ≤  0.001- Unpaired <i>t</i> test. …"

Impact of Oral Semaglutide on Kidney Outcomes in People with Type 2 Diabetes: Results from the SOUL Randomized Trial حسب Johannes F. E. Mann (22017555)

"…</p><p dir="ltr">RESULTS</p><p dir="ltr">Among 9,650 participants, mean eGFR was 73.8 mL/min/1.73 m2 and follow-up was 47.5 months. …"

Data Sheet 1_Associations between obesity and arterial stiffness assessed by cardio-ankle vascular index in healthy children and adolescents.docx حسب Yuko Horikoshi (12202859)

"…</p>Methods<p>This was a cross-sectional study conducted in 2024. We evaluated CAVI and its associated factors in 590 children aged 6–15 years (mean age: 10.5 years, 51.0% female). …"

Data Sheet 1_Top motor and non-motor complaints in patients with Parkinson's disease.docx حسب José Fidel Baizabal-Carvallo (11416508)

"…Responses were divided into three tiers.</p>Results<p>We studied 230 consecutive patients with PD. There were 130 (56.5%) male patients, with the mean age at evaluation of 67.7 ± 11.06 years. …"

Identification of novel pathogenic mutations in <i>ATP6V0A4</i> associated with distal renal tubular acidosis and analysis of wild-type expression in glomerular disease حسب Yaru Jiang (17458815)

"…If untreated, it can result in a significant electrolyte imbalance and progressive chronic kidney disease (CKD). …"

Supplementary file 1_Soluble suppression of tumorigenicity-2 changes during cardiotoxic cancer treatment: a systematic review and meta-analysis.docx حسب Luca Fazzini (22599380)

"…Using random-effects models, mean differences (MD), and standardized MD (SMD), we analyzed (i) ST2 longitudinal changes, (ii) the association between ST2 and cardiotoxicity [defined through left ventricular ejection fraction (LVEF)] providing pooled estimates of correlations, and (iii) the SMD variations among biomarkers.…"

CCDC66 localizes to the axoneme and regulates primary cilium stability but not cilia formation in IMCD3 cells. حسب Jovana Deretic (13113617)

"…<i>n</i> > 600 cells for control and >400 cells for CCDC66 depletion. The mean cilia length in CCDC66-depleted cells decreased to 0.67-fold compared to the mean control length. …"

Telomere-to-telomere genome of <i>Phoebe chekiangensis</i> reveals age-dependent CHG hypomethylation promoting floral transition via MADS-box gene activation حسب Qinglin Sun (17811556)

"…Their ectopic expression in Arabidopsis significantly accelerated flowering. Whole-genome bisulfite sequencing revealed an age-related decrease in CHG methylation, particularly at the PcMADS19.1 locus. …"