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8621
Image 2_Pharmacological inhibition of the RhoA pathway by melatonin reduces viral replication and proinflammatory response against ZIKV and DENV-4 neuroinfections.tiff
Published 2025“…</p>Results<p>Melatonin treatment significantly reduced ZIKV and DENV-4 replication and the associated inflammatory response in U87-MG cells. …”
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8622
Shikonin promotes ferroptosis though NSUN2-mediated m<sup>5</sup>C methylation modification of TFRC in acute myelocytic leukemia
Published 2025“…To assess cell viability and death, we employed Cell Counting Kit-8 and propidium iodide staining. …”
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8623
Data Sheet 1_Identification of a multiple DAMP scavenger mimicking the DAMP-binding site of TLR4 to ameliorate lethal sepsis.pdf
Published 2025“…Additionally, OP18-treated septic mice demonstrated reduced blood organ injury markers, decreased proinflammatory cytokine levels, attenuated ALI, and improved survival. …”
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8624
Data Sheet 1_Identification of novel gut microbiota-related biomarkers in cerebral hemorrhagic stroke.zip
Published 2025“…Machine learning identified four hub genes—LEF1, ITGAX, BLVRB, and ATF4. All were significantly upregulated in ICH tissues and plasma, correlating with immune cell infiltration. …”
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8625
Image 3_StACS3-mediated drought stress adaptation in potato involves interactions with StPP2C2 and St14-3-3 proteins.tiff
Published 2025“…In contrast, silencing StACS3 significantly reduces stress-induced ethylene accumulation and enhances drought resilience, including decreased cell death and increased antioxidant activity. …”
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8626
Image 11_Potential marker genes for psoriasis revealed based on single-cell sequencing and Mendelian randomization analysis.tif
Published 2025“…</p>Results<p>Seven genetically informed candidate genes were identified as being significantly associated with psoriasis susceptibility. …”
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8627
Data Sheet 5_StACS3-mediated drought stress adaptation in potato involves interactions with StPP2C2 and St14-3-3 proteins.pdf
Published 2025“…In contrast, silencing StACS3 significantly reduces stress-induced ethylene accumulation and enhances drought resilience, including decreased cell death and increased antioxidant activity. …”
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8628
Image 3_Potential marker genes for psoriasis revealed based on single-cell sequencing and Mendelian randomization analysis.tif
Published 2025“…</p>Results<p>Seven genetically informed candidate genes were identified as being significantly associated with psoriasis susceptibility. …”
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8629
Characteristics of specialists at day centers.
Published 2025“…To address obesity in adults with severe intellectual disabilities who are highly dependent, we developed the “Conflict-Free Weight Loss Program for Adults with Severe ID and Autism” to support their mothers and piloted the program, and the results showed that it was effective for weight loss. …”
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8630
Table 2_Potential marker genes for psoriasis revealed based on single-cell sequencing and Mendelian randomization analysis.xlsx
Published 2025“…</p>Results<p>Seven genetically informed candidate genes were identified as being significantly associated with psoriasis susceptibility. …”
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8631
Data Sheet 1_Brain-derived uroguanylin as a regulator of postprandial brown adipose tissue activation: a potential therapeutic approach for metabolic disorders.docx
Published 2025“…Background<p>Preclinical and clinical research of insulin resistance and glucose homeostasis in metabolic disorders are essential. In this study, we aim to determine the expression of uroguanylin (UGN) in the mouse and human brain, its regulatory mechanisms, and its significance to patients with obesity and type 2 diabetes (T2D).…”
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8632
Data Sheet 1_Phyllosphere microbiome responses to nano-berberine and chemical fungicides in powdery mildew infected strawberry.pdf
Published 2025“…The results showed that nano-fungicide application significantly reduced the disease index of powdery mildew and markedly decreased its incidence in field-grown strawberries, ultimately lowering leaf disease incidence to 5.06% with a control efficacy of 96.81%. …”
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8633
Data Sheet 2_Identification of novel gut microbiota-related biomarkers in cerebral hemorrhagic stroke.zip
Published 2025“…Machine learning identified four hub genes—LEF1, ITGAX, BLVRB, and ATF4. All were significantly upregulated in ICH tissues and plasma, correlating with immune cell infiltration. …”
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8634
Movie 2 Rik<sup>null</sup> vs. WT.
Published 2024“…<div><p>Here, we describe a spontaneous mouse mutant with a deletion in a predicted gene <i>2310061I04Rik</i> (<i>Rik</i>) of unknown function located on chromosome 17. …”
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8635
Supplementary file 2_Effects of Lactiplantibacillus plantarum DSM 33464 in children with elevated blood lead levels: a randomized, double-blind, placebo-controlled study.docx
Published 2025“…Introduction<p>Approximately one-third of the world’s children have elevated blood lead levels (BLLs), which may lead to often-irreversible decreased intelligence, behavioral difficulties, and learning problems. …”
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8636
Data Sheet 1_StACS3-mediated drought stress adaptation in potato involves interactions with StPP2C2 and St14-3-3 proteins.pdf
Published 2025“…In contrast, silencing StACS3 significantly reduces stress-induced ethylene accumulation and enhances drought resilience, including decreased cell death and increased antioxidant activity. …”
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8637
Data Sheet 1_A novel bioactive peptide-peptoid hybrid of alpha-calcitonin gene-related peptide protects against pressure-overload induced heart failure.docx
Published 2025“…NMEG-CGRP administration significantly attenuated these TAC-induced adverse cardiac effects in the HF mice.…”
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8638
Data Sheet 4_StACS3-mediated drought stress adaptation in potato involves interactions with StPP2C2 and St14-3-3 proteins.pdf
Published 2025“…In contrast, silencing StACS3 significantly reduces stress-induced ethylene accumulation and enhances drought resilience, including decreased cell death and increased antioxidant activity. …”
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8639
Primers used in RT-qPCR.
Published 2025“…Additionally, LBH589 significantly decreased mitochondrial reactive oxygen species (mtROS) and oxidized mitochondrial DNA (Ox-mtDNA), key triggers of inflammasome activation. …”
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8640
<b>Liraglutide treatment reverses unconventional cellular defects in induced pluripotent stem cell-derived β cells harboring a partially functional </b><b><i>WFS1</i></b><b> varian...
Published 2025“…Pancreatic β cells obtained from patient-derived induced Pluripotent Stem Cells (iPSCs) carrying this <i>WFS1 </i>variant exhibited reduced insulin processing and impaired secretory granule maturation, as evidenced by proinsulin accumulation and decreased prohormone convertase PC1/3. Moreover, they exhibited dysregulated Ca<sup>2+</sup> fluxes due to altered transcription of Ca<sup>2+</sup>-related genes, including <i>CACNA1D</i>, and significantly reduced <i>SNAP25</i> levels, leading to uncoordinated oscillations and poor glucose responsiveness. …”