Primer sequences. by Ceyan Kuang (8554557)

“…Microinjection of HL-IR double-stranded RNA (dsRNA) showed that reduced transcript levels led to significant decreases in the tick repellency rate from cinnamaldehyde and the EAG response of Haller’s organ. …”

SOSV loads in specimens obtained from bats in the SOSV-MARV experimental cohort. by Amy J. Schuh (8520354)

KASV loads in specimens obtained from bats in the KASV-MARV experimental cohort. by Amy J. Schuh (8520354)

All measurement data obtained for this study. by Brendan M. Anderson (11234356)

“…One clade increased in size, one decreased, and another exhibited no substantial change. …”

Regional stratigraphic correlation. by Brendan M. Anderson (11234356)

“…One clade increased in size, one decreased, and another exhibited no substantial change. …”

Pre- and post-study virus-specific IgG responses for bats in the SOSV-MARV and KASV-MARV experimental cohorts. by Amy J. Schuh (8520354)

Discovery of NP3-742: A Structurally Diverse NLRP3 Inhibitor Identified through an Unusual Phenol Replacement by Juraj Velcicky (2201350)

“…Initial indole analog <b>7</b> demonstrated a robust in vivo IL-1β inhibition, but also a significant hERG inhibition. Decreasing lipophilicity led to the discovery of <b>NP3-742</b>, demonstrating a favorable overall profile including diminished hERG inhibition and in vivo efficacy in a mouse peritonitis model.…”

Discovery of NP3-742: A Structurally Diverse NLRP3 Inhibitor Identified through an Unusual Phenol Replacement by Juraj Velcicky (2201350)

“…Initial indole analog <b>7</b> demonstrated a robust in vivo IL-1β inhibition, but also a significant hERG inhibition. Decreasing lipophilicity led to the discovery of <b>NP3-742</b>, demonstrating a favorable overall profile including diminished hERG inhibition and in vivo efficacy in a mouse peritonitis model.…”

Discovery of NP3-742: A Structurally Diverse NLRP3 Inhibitor Identified through an Unusual Phenol Replacement by Juraj Velcicky (2201350)

“…Initial indole analog <b>7</b> demonstrated a robust in vivo IL-1β inhibition, but also a significant hERG inhibition. Decreasing lipophilicity led to the discovery of <b>NP3-742</b>, demonstrating a favorable overall profile including diminished hERG inhibition and in vivo efficacy in a mouse peritonitis model.…”

Primers used in ChIP-PCR. by Lorenza Cutrone (21144285)

“…In lymphatic endothelial cells infected with KSHV and in gastric cancer cells positive for EBV, ectopic HSF2 enhances the expression of lytic genes; While knocking down HSF2 significantly decreases their expression. HSF2 overexpression is accompanied by decreased levels of repressive histone marks at the promoters of the lytic regulators KSHV ORF50 and EBV BZLF1, both characterized by poised chromatin features. …”

Primers used in RTqPCR. by Lorenza Cutrone (21144285)

“…In lymphatic endothelial cells infected with KSHV and in gastric cancer cells positive for EBV, ectopic HSF2 enhances the expression of lytic genes; While knocking down HSF2 significantly decreases their expression. HSF2 overexpression is accompanied by decreased levels of repressive histone marks at the promoters of the lytic regulators KSHV ORF50 and EBV BZLF1, both characterized by poised chromatin features. …”

All-Atom Simulations Reveal the Effect of Membrane Composition on the Signaling of the NKG2A/CD94/HLA‑E Immune Receptor Complex by Martin Ljubič (15680161)

“…These variations are particularly evident in the intracellular domain of NKG2A, manifested as changes in mobility, tyrosine exposure, and interdomain communication. Additionally, we found that a large concentration of negative charge at the surface of the POPA-based membrane greatly increased the number of contacts with lipid molecules and significantly decreased the exposure of intracellular NKG2A ITIM regions to water molecules, thus likely halting the signal transduction process. …”

Stereotactic injection of AAV-miR-129-5p attenuated microglia activation in depressed mice. by Qiaozhen Qin (13159201)

Stereotactic injection of AAV-miR-129-5p suppressed astrocyte activation in depressed mice. by Qiaozhen Qin (13159201)

Data used to generate Figs 2–7 and S1 Fig. by Amy J. Schuh (8520354)

“…Compared to the MARV-monoinfected bat group, the SOSV+MARV-coinfected bat group exhibited a significantly shortened duration of MARV oral shedding and a significantly decreased anti-MARV IgG response, which may increase the capacity for MARV reinfection. …”

CPSF6-NLS chimeras confer virus-specific infectivity defects. by Nicholas Rohlfes (20577485)

“…Results (mean ± SEM) are representative from 3 independent experiments with at least technical duplicate samples per experiment. …”

Relationship between miR-129-5p and Mysm1 in depressed mice. by Qiaozhen Qin (13159201)

Weights and body temperatures of bats assigned to the SOSV-MARV and KASV-MARV experimental cohorts. by Amy J. Schuh (8520354)

MARV shedding dynamics in bats from the KASV-MARV experimental cohort. by Amy J. Schuh (8520354)

Cumulative MARV shedding in bats from the SOSV-MARV and KASV-MARV experimental cohort. by Amy J. Schuh (8520354)