Supplementary Material for: Construction of a hybrid vaccine based on Der f 35-derived peptides with reduced allergenicity by Hu H. (4145581)

“…The IgE-ELISA revealed a significant reduction in IgE-binding activity to the vaccine when compared to wild-type Der f 35 (p < 0.0001), the decreased allergenicity were further confirmed by IgE-Western blot, inhibition ELISA and BAT, respectively. …”

IFN-responsive and anti-viral pathways are induced in γδ T cells post-HIV-1 acquisition. by Gina L. Griffith (20649097)

DataSheet2_Chitinase 1: a novel therapeutic target in metabolic dysfunction-associated steatohepatitis.docx by Jung Hoon Cha (19723588)

“…</p>Conclusions<p>Our study underscores the pivotal role of CHIT1 in MASH. The observed significant improvement in inflammation and hepatic fibrosis, particularly at higher doses of the CHIT1 inhibitor, strongly suggests the potential of CHIT1 as a therapeutic target in MASH accompanied by progressive liver fibrosis.…”

DataSheet1_Chitinase 1: a novel therapeutic target in metabolic dysfunction-associated steatohepatitis.zip by Jung Hoon Cha (19723588)

“…</p>Conclusions<p>Our study underscores the pivotal role of CHIT1 in MASH. The observed significant improvement in inflammation and hepatic fibrosis, particularly at higher doses of the CHIT1 inhibitor, strongly suggests the potential of CHIT1 as a therapeutic target in MASH accompanied by progressive liver fibrosis.…”

Data Sheet 1_Microbial dysbiosis in obstructive sleep apnea: a systematic review and meta-analysis.docx by Yang Guo (399435)

“…Furthermore, in comparison to the non-OSA individuals, the gut environment of patients with OSA exhibited an increased relative abundance of phylum Firmicutes, along with elevated levels of genera Lachnospira; conversely, there was a decreased relative abundance of phylum Bacteroidetes and genus Ruminococcus and Faecalibacterium. …”

Cophylogenetic signal occurs between hominids and fungal OTUs clustered at 99% similarity. by Emily P. Van Syoc (22169869)

Cophylogenetic signal occurs between diverse gut fungal taxa and hominids. by Emily P. Van Syoc (22169869)

Cophylogenetic signal occurs between diverse gut fungal taxa and hominids (continued from Fig 3). by Emily P. Van Syoc (22169869)

“…<p><b>(A–E)</b> Neighbor-joining trees of fungal OTUs that display cophylogeny with hominid hosts, ordered by decreasing PACo R2. …”

Table_1_Higher oxidative balance score is associated with lower female infertility: a cross-sectional study.DOCX by Xiong Lei (3847897)

“…When OBS was used as a categorical variable, female infertility decreased by 60% in the highest OBS group compared with the lowest OBS group (OR, 0.40; 95% CI, 0.21 to 0.74). …”

Data Sheet 1_Efficacy of Schisandra chinensis in liver injury: a systematic review and preclinical meta-analysis.docx by Bo-Hao Huang (18608359)

“…Schisandra chinensis, a traditional Chinese medicinal herb with a history of use spanning over 2,000 years, exhibits significant hepatoprotective, antioxidant, anti-inflammatory, and anti-apoptotic effects. …”

Figure 2 from Metabolomic Biomarkers in Blood Samples Identify Cancers in a Mixed Population of Patients with Nonspecific Symptoms by James R. Larkin (14936324)

“…<p><b>A,</b> Mean NMR spectra for samples from unwell patients with either confirmed solid tumor diagnoses (red, <i>n</i> = 17) or confirmed noncancer diagnoses (black, <i>n</i> = 175). …”

Validation of the optimum formula. by Randa Mohammed Zaki (21637175)

“…<div><p>The goal of this study was the formulation and optimization by statistical means of bilosomal formulations of axitinib (AXT) in order to improve its anticancer efficacy in a targeted manner. …”

Table 2_Cost-effectiveness of the 3E model in diabetes management: a machine learning approach to assess long-term economic impact.docx by Supriya Raghav (21412907)

“…</p>Methods<p>We conducted an observational longitudinal descriptive analysis involving 320 patients, who were grouped into intervention and control groups over a 24-month period.</p>Results<p>The 3E model demonstrated significant cost reductions, with the intervention group achieving a 74.3% decrease in total costs compared to 41.8% in the control group while maintaining the same level of glycemic control. …”

Table 1_Cost-effectiveness of the 3E model in diabetes management: a machine learning approach to assess long-term economic impact.xlsx by Supriya Raghav (21412907)

“…</p>Methods<p>We conducted an observational longitudinal descriptive analysis involving 320 patients, who were grouped into intervention and control groups over a 24-month period.</p>Results<p>The 3E model demonstrated significant cost reductions, with the intervention group achieving a 74.3% decrease in total costs compared to 41.8% in the control group while maintaining the same level of glycemic control. …”

Phylosymbiosis between primates and their gut mycobiomes. by Emily P. Van Syoc (22169869)

“…<b>(C)</b> Pairwise Bray–Curtis distances between individual samples for within-host (intraspecific) and between-host (interspecific) comparisons are shown for each host species, ordered by decreasing median of intraspecific distances. Asterisks denote statistical significance (<i>T</i> test <i><i>P</i></i> < 0.05). …”

Image 1_Practical utility of meropenem therapeutic drug monitoring: a systematic review of evidence for clinical application.pdf by Yi-Chang Zhao (14080107)

“…CRP levels decreased significantly (mean difference = 14.91; 95% CI: 2.79–27.02), while changes in PCT, WBC, and neutrophil ratios were non-significant. …”

Image 2_Practical utility of meropenem therapeutic drug monitoring: a systematic review of evidence for clinical application.pdf by Yi-Chang Zhao (14080107)

“…CRP levels decreased significantly (mean difference = 14.91; 95% CI: 2.79–27.02), while changes in PCT, WBC, and neutrophil ratios were non-significant. …”

Engineered deletions of 1-TbAd biosynthesis genes reveal gene functions and greatly expand the lipid signature. by Jacob A. Mayfield (19762468)

“…The numbers of changed events (Benjamini–Hochberg adjusted <i>p</i> < 0.05 and 2-fold or greater change), the gene-dependent events (blue rectangle), and the most abundant 1- and <i>N</i>^<i>6</i>-tuberculosinyladenosine peaks are indicated as in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002813#pbio.3002813.g002" target="_blank">Fig 2A</a>. …”

Table 1_Association between androgenetic alopecia and psychological well-being: a systematic review and meta-analysis.docx by Yuan Kong (110669)

“…Background<p>Androgenetic alopecia (AGA) is a prevalent chronic condition with health burden, yet its association with psychological well-being remains inconsistent. …”

Datasheet1_Fever management in children and insights into fever of unknown origin: a survey among Italian pediatricians.pdf by Elena Chiappini (304802)

“…Compared to what participants reported for the treatment of non-prolonged fever, a significant decrease in the prescription of paracetamol as first-choice drug in children with FUO was observed (80.5%; P < 0.0001). …”