Data Sheet 1_A dual inhibitor of TrxR1 and XIAP induces pyroptosis in melanoma.docx by Yuan Wang (14955)

“…Previous studies have shown that both X-linked inhibitor of apoptosis (XIAP) and thioredoxin reductase 1 (TrxR1) participate in the resistance of melanoma to chemotherapy-induced cell death. In this study, we designed and synthesized a series of derivatives of natural compounds derived from Toona sinensis to simultaneously inhibit TrxR1 activity and destabilize the XIAP protein. …”

Supplementary Material for: Innovative regenerative treatment with Nanofat injection for hypertensive ischemic leg ulcer: a case report by figshare admin karger (2628495)

“…Case Presentation: We describe a 75-year-old female patient with a chronic ischemic ulcer measuring 30.1 cm² and persisting for more than 5 years. …”

Table2_Causal relationship between antihypertensive drugs and Hashimoto’s thyroiditis: a drug-target Mendelian randomization study.xlsx by Bing Cui (179696)

“…Moreover, genetically mimicking the use of loop diuretics (OR [95% CI]: 0.94 [0.91, 0.97]; p = 3.57×10^-5) and thiazide diuretics (0.98 [0.96, 0.99]; p = 3.83×10^-3) showed a significant association with a decreased risk of HT only in European population. …”

Image1_Causal relationship between antihypertensive drugs and Hashimoto’s thyroiditis: a drug-target Mendelian randomization study.tif by Bing Cui (179696)

“…Moreover, genetically mimicking the use of loop diuretics (OR [95% CI]: 0.94 [0.91, 0.97]; p = 3.57×10^-5) and thiazide diuretics (0.98 [0.96, 0.99]; p = 3.83×10^-3) showed a significant association with a decreased risk of HT only in European population. …”

Table4_Causal relationship between antihypertensive drugs and Hashimoto’s thyroiditis: a drug-target Mendelian randomization study.xlsx by Bing Cui (179696)

“…Moreover, genetically mimicking the use of loop diuretics (OR [95% CI]: 0.94 [0.91, 0.97]; p = 3.57×10^-5) and thiazide diuretics (0.98 [0.96, 0.99]; p = 3.83×10^-3) showed a significant association with a decreased risk of HT only in European population. …”

Table5_Causal relationship between antihypertensive drugs and Hashimoto’s thyroiditis: a drug-target Mendelian randomization study.xlsx by Bing Cui (179696)

“…Moreover, genetically mimicking the use of loop diuretics (OR [95% CI]: 0.94 [0.91, 0.97]; p = 3.57×10^-5) and thiazide diuretics (0.98 [0.96, 0.99]; p = 3.83×10^-3) showed a significant association with a decreased risk of HT only in European population. …”

Image2_Causal relationship between antihypertensive drugs and Hashimoto’s thyroiditis: a drug-target Mendelian randomization study.tif by Bing Cui (179696)

“…Moreover, genetically mimicking the use of loop diuretics (OR [95% CI]: 0.94 [0.91, 0.97]; p = 3.57×10^-5) and thiazide diuretics (0.98 [0.96, 0.99]; p = 3.83×10^-3) showed a significant association with a decreased risk of HT only in European population. …”

Table1_Causal relationship between antihypertensive drugs and Hashimoto’s thyroiditis: a drug-target Mendelian randomization study.xlsx by Bing Cui (179696)

“…Moreover, genetically mimicking the use of loop diuretics (OR [95% CI]: 0.94 [0.91, 0.97]; p = 3.57×10^-5) and thiazide diuretics (0.98 [0.96, 0.99]; p = 3.83×10^-3) showed a significant association with a decreased risk of HT only in European population. …”

Table3_Causal relationship between antihypertensive drugs and Hashimoto’s thyroiditis: a drug-target Mendelian randomization study.xlsx by Bing Cui (179696)

“…Moreover, genetically mimicking the use of loop diuretics (OR [95% CI]: 0.94 [0.91, 0.97]; p = 3.57×10^-5) and thiazide diuretics (0.98 [0.96, 0.99]; p = 3.83×10^-3) showed a significant association with a decreased risk of HT only in European population. …”

Data Sheet 1_Microbial dysbiosis in obstructive sleep apnea: a systematic review and meta-analysis.docx by Yang Guo (399435)

“…Background<p>The association between the microbiota and obstructive sleep apnea (OSA) remains understudied. In this study, we conducted a comprehensive systematic review and meta-analysis of studies investigating the diversity and relative abundance of microbiota in the gut, respiratory tracts and oral cavity of patients with OSA, aiming to provide an in-depth characterization of the microbial communities associated with OSA.…”

Table 1_ZmEXPB7, a β-expansin gene, contributes to drought tolerance in Arabidopsis.docx by Jing Xiong (218613)

“…<p>Drought stress poses a significant threat to maize productivity, highlighting the need to elucidate molecular mechanisms underlying drought tolerance. …”

Video 5_Takotsubo syndrome following mitral transcatheter edge-to-edge repair: a case report and literature review.mpg by Si Pang (5959094)

“…Despite the procedural success, multi-lead T-wave inversions and a 43% decrease in ejection fraction accompanied by new apical hypokinesis were noted postoperatively. …”

Video 4_Takotsubo syndrome following mitral transcatheter edge-to-edge repair: a case report and literature review.mpg by Si Pang (5959094)

“…Despite the procedural success, multi-lead T-wave inversions and a 43% decrease in ejection fraction accompanied by new apical hypokinesis were noted postoperatively. …”

Image 1_Takotsubo syndrome following mitral transcatheter edge-to-edge repair: a case report and literature review.jpeg by Si Pang (5959094)

“…Despite the procedural success, multi-lead T-wave inversions and a 43% decrease in ejection fraction accompanied by new apical hypokinesis were noted postoperatively. …”

<b>Prevalence and Correlates of Diabetes Distress in Pregnant Individuals With Preexisting Diabetes: A Cross-Sectional Study</b> by Holly Tschirhart (823039)

“…Having a common-law partner or spouse, comorbid depression, depressive symptoms, and depression scores were all significantly associated with increased PAID scores (P <0.05). …”

Data Sheet 1_Effects of icariin as a feed additive on the reproductive function in bucks (Capra hircus).docx by Fang-e Zhao (20140809)

“…However, the serum concentration of GnRH in the ICA group initially increased, followed by a subsequent decrease (p < 0.05). The hypothalamic concentrations of dopamine (DA) and 5-hydroxytryptamine (5-HT) were significantly higher in the ICA group compared to the control group (p < 0.01). …”

Data Sheet 1_Perceived protective behavioral changes in Chinese residents post-dynamic zero-COVID policy lifting: a cross-sectional study.docx by Yuan-Yuan Song (6287387)

“…The mean scores for the two vaccination-related items were significantly greater than the hypothesized no-change value of 2 (p < 0.001). …”

Table 2_Mortality and trends of pulmonary arterial hypertension, 1990–2021: a population-based study.docx by Linhong Jiang (5004347)

“…Background<p>Pulmonary arterial hypertension (PAH) is a progressive disease associated with high fatality rate. …”

Table 1_Mortality and trends of pulmonary arterial hypertension, 1990–2021: a population-based study.docx by Linhong Jiang (5004347)

“…Background<p>Pulmonary arterial hypertension (PAH) is a progressive disease associated with high fatality rate. …”

Table 3_Mortality and trends of pulmonary arterial hypertension, 1990–2021: a population-based study.docx by Linhong Jiang (5004347)

“…Background<p>Pulmonary arterial hypertension (PAH) is a progressive disease associated with high fatality rate. …”