Significant clusters: Coronal PET images showing brain regions with significant (p < 0.001 and K > 50) metabolic inhibition (A-G) and activation (H-I) in rats following cocaine sel... by Christopher Rowan (21499924)

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Cinacalcet administered early in the inactive phase markedly decrease parathyroid Ki-67 index. by Søren Egstrand (10906087)

“…All groups were compared by Kruskal Wallis test with <i>post hoc</i> test after Dunn with Bonferroni adjustment showing significant decreased Ki-67 labeling index of <i>Cina1</i> compared to <i>Cina2</i> (p = 0.006) and the untreated CKD groups (p = 0.0001 and p = 0.0002, respectively). …”

RTA408 significantly reduces RGCs loss. by Hongmei Qian (538647)

Group-level narrow- and broad-band spectral changes after hemispherotomy reveal a marked EEG slowing of the isolated cortex, robust across patients. by Michele Angelo Colombo (22446342)

“…<b>(E)</b> Following surgery, the PSD became steeper in the disconnected cortex, as indexed by a significant pre- to post-decrease in Spectral Exponent toward more negative values, observed in all patients (i.e., all negative post-pre differences for the disconnected cortex). …”

Loss of RBM-26 causes mitochondria dysfunction in PLM. by Tamjid A. Chowdhury (14149846)

DALY and HLY in Portugal, 1990–2019. The first graph shows a decreasing trend of DALY and the second graph shows an increasing trend of HLY. by Aida Isabel Tavares (12080156)

Join-point regression analysis of the statistically significant linear increase in use of antidementia and antipsychotics during the observed time period. by Jelena Filimonovic (22305307)

Knockdown of MRN complex decreases HBV cccDNA level. by Kaitao Zhao (3617825)

Knockdown of MRN complex decreases HBV cccDNA level. by Kaitao Zhao (3617825)

Contrasting Size Dependence of Photochemical Lifetimes of Polypropylene and Expanded Polystyrene Microplastics in Surface Waters by Ariana Patterson (22764051)

“…Sunlight-driven photochemistry can dissolve buoyant microplastics, producing dissolved organic carbon (DOC). We hypothesized that plastic dissolution would increase linearly with increasing surface area (SA)-to-volume (V) ratio as plastics decrease in size. …”

Participant retention flowchart. by Carolin Oetzmann (11397968)

“…We identified a 4-class solution: (1) severe with appetite decrease, (2) severe with appetite increase, (3) moderate severity and (4) low severity. …”

Cytokine production in mice transplanted with feces from people with intestinal protists. by Oswaldo Partida-Rodríguez (734406)

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NK cell frequencies in the colon and spleen of mice with FMT from people with intestinal protists. by Oswaldo Partida-Rodríguez (734406)

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Frequencies of regulatory T cell in mice transplanted with feces from donors with intestinal protists. by Oswaldo Partida-Rodríguez (734406)

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Cytokine production in mice transplanted with gut bacteriome material from individuals parasitized with intestinal protozoa. by Oswaldo Partida-Rodríguez (734406)

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