Image 12_RBM15-mediated metabolic reprogramming boosts immune response in colorectal cancer.jpeg by Chen Wang (88408)

“…Functional studies demonstrated that RBM15 loss led to increased expression of fumarate hydratase (FH). This led to decreased levels of fumarate, a metabolite known to suppress anti-tumor immune responses. …”

Image 2_Human beta defensin-2 protects the epithelial barrier during methicillin-resistant Staphylococcus aureus infection in chronic rhinosinusitis with nasal polyps.tif by Tengfei Tian (1793545)

“…In addition, the hBD-2 protein was negatively correlated with the Lund–Mackay CT score and was positively correlated with the neutrophil levels in CRSwNP. The presence of hBD-2 significantly reduced the invasive ability of MRSA in HNECs. …”

Image 1_Integrated metagenomics and metabolomics analysis reveals dynamic changes of microbiota and metabolic profile during fermentation of cigar tobacco (Nicotiana tabacum L.) le... by Ting Yang (189879)

“…<p>Optimizing fermentation duration is critical for producing high-quality cigar tobacco leaves This study examines changes in microorganisms and metabolites during CTL fermentation at four time points: 0 days (T0), 25 days (T1), 50 days (T2), and 75 days (T3). We observed a decreasing trend in total soluble sugars, starch, total nitrogen, and nicotine levels as fermentation progressed. …”

Supplementary file 1_Systemic lipid and glucose modulation differentially affects cognitive function and neuroinflammation in a mouse model of Alzheimer’s disease.docx by Demos Kynigopoulos (12420457)

“…Gliclazide reduced neuroinflammation and partially preserved glial and neuronal markers. Both treatments decreased amyloid burden and modulated adipokine levels, with Alirocumab elevating leptin and omentin in brain and serum. …”

Table 5_Comparative genomics and metabolomics reveal phytohormone production, nutrient acquisition, and osmotic stress tolerance in Azotobacter chroococcum W5.docx by M. Elakkya (21760439)

“…Under salt and osmotic stress, A. chroococcum W5 metabolomic profiling revealed adaptive responses, including elevated levels of osmoprotectants (proline, glycerol) and oxidative stress markers such as 2-hydroxyglutarate, while putrescine and glycine decreased.…”

Image 4_Integrated metagenomics and metabolomics analysis reveals dynamic changes of microbiota and metabolic profile during fermentation of cigar tobacco (Nicotiana tabacum L.) le... by Ting Yang (189879)

“…<p>Optimizing fermentation duration is critical for producing high-quality cigar tobacco leaves This study examines changes in microorganisms and metabolites during CTL fermentation at four time points: 0 days (T0), 25 days (T1), 50 days (T2), and 75 days (T3). We observed a decreasing trend in total soluble sugars, starch, total nitrogen, and nicotine levels as fermentation progressed. …”

Table 7_Comparative genomics and metabolomics reveal phytohormone production, nutrient acquisition, and osmotic stress tolerance in Azotobacter chroococcum W5.xlsx by M. Elakkya (21760439)

“…Under salt and osmotic stress, A. chroococcum W5 metabolomic profiling revealed adaptive responses, including elevated levels of osmoprotectants (proline, glycerol) and oxidative stress markers such as 2-hydroxyglutarate, while putrescine and glycine decreased.…”

Data Sheet 1_BMP9 induces postnatal zonal stratification of immature articular cartilage through reconfiguration of the existing collagen framework.pdf by Miles Anderson-Watters (20626604)

“…In explants exposed to BMP9, collagen fibrils underwent angular displacement from 19° to 78° with respect to the surface, cell density decreased 1.77-fold, and chondrons were significantly larger. …”

Data Sheet 2_Bifidobacterium depletion promotes goiter via gut-thyroid axis: evidence from Mendelian randomization and experimental validation.xlsx by Wenyong Liao (21669332)

“…In goiter rats, 16S rRNA sequencing revealed eight differentially abundant microbial taxa including significantly reduced B. bifidum, accompanied by: (1) impairment of two butyrate synthesis pathways, (2) decreased levels of six SCFAs (including butyrate), (3) impaired thyroid iodine uptake, (4) downregulated NIS expression, and (5) thyroid dysfunction [reduced triiodothyronine (T3), thyroxine (T4), free T3 (FT3), free T4 (FT4) with elevated thyroid-stimulating hormone (TSH)] - all measurements showing statistical significance (p < 0.05).…”

Table_1_Baicalin enhances antioxidant, inflammatory defense, and microbial diversity of yellow catfish (Pelteobagrus fulvidraco) infected with Aeromonas hydrophila.DOCX by Pupu Yan (19710400)

“…Additionally, baicalin at an appropriate dosage was found to increase levels of SOD, GSH, CAT, ACP, and AKP in yellow catfish (P < 0.05), while simultaneously decreasing MDA accumulation and the mRNA expression of inflammatory markers such as Keap1, IL1, IFN-γ, and TNF-α, (P < 0.05). …”

Image 4_NLRP3 deficiency aggravated DNFB-induced chronic itch by enhancing type 2 immunity IL-4/TSLP-TRPA1 axis in mice.tif by Si-Ting Huang (5591432)

“…Recombinant IL-18 also decreased the expression of TRPA1, IL-4, and TSLP.</p>Discussion<p>These findings suggested that the absence of Nlrp3 aggravated DNFB-induced chronic itch by exacerbating type 2 immunity in the skin and enhancing the IL-4/TSLP-TRPA1 axis, potentially driven by reduced IL-18 levels.…”

Data Sheet 1_Bifidobacterium depletion promotes goiter via gut-thyroid axis: evidence from Mendelian randomization and experimental validation.xls by Wenyong Liao (21669332)

“…In goiter rats, 16S rRNA sequencing revealed eight differentially abundant microbial taxa including significantly reduced B. bifidum, accompanied by: (1) impairment of two butyrate synthesis pathways, (2) decreased levels of six SCFAs (including butyrate), (3) impaired thyroid iodine uptake, (4) downregulated NIS expression, and (5) thyroid dysfunction [reduced triiodothyronine (T3), thyroxine (T4), free T3 (FT3), free T4 (FT4) with elevated thyroid-stimulating hormone (TSH)] - all measurements showing statistical significance (p < 0.05).…”

Table 1_NLRP3 deficiency aggravated DNFB-induced chronic itch by enhancing type 2 immunity IL-4/TSLP-TRPA1 axis in mice.docx by Si-Ting Huang (5591432)

“…Recombinant IL-18 also decreased the expression of TRPA1, IL-4, and TSLP.</p>Discussion<p>These findings suggested that the absence of Nlrp3 aggravated DNFB-induced chronic itch by exacerbating type 2 immunity in the skin and enhancing the IL-4/TSLP-TRPA1 axis, potentially driven by reduced IL-18 levels.…”

Table 1_High-calcium milk improves osteoporosis in postmenopausal women by regulating intestinal flora and steroid hormone biosynthesis.docx by Yanyan Zhao (211551)

“…</p>Results<p>A one-year randomized controlled trial showed that the high-calcium milk group significantly increased lumbar spine bone mineral density (L1-4 BMD), slowed bone loss in the left hip and femoral neck, elevated serum phosphorus and 25-hydroxyvitamin D levels, and modulated the bone formation marker procollagen type I N-terminal propeptide compared with the regular milk group at 6 months. 16S ribosomal ribonucleic acid sequencing showed that high-calcium milk significantly altered the β-diversity of the intestinal flora, increasing the abundance of beneficial bacteria such as Bacteroides, Oscillibacter, and Subdoligranulum, while decreasing the abundance of Firmicutes and Weissella at 12 months. …”

Image 1_NLRP3 deficiency aggravated DNFB-induced chronic itch by enhancing type 2 immunity IL-4/TSLP-TRPA1 axis in mice.tif by Si-Ting Huang (5591432)

“…Recombinant IL-18 also decreased the expression of TRPA1, IL-4, and TSLP.</p>Discussion<p>These findings suggested that the absence of Nlrp3 aggravated DNFB-induced chronic itch by exacerbating type 2 immunity in the skin and enhancing the IL-4/TSLP-TRPA1 axis, potentially driven by reduced IL-18 levels.…”

Image 3_NLRP3 deficiency aggravated DNFB-induced chronic itch by enhancing type 2 immunity IL-4/TSLP-TRPA1 axis in mice.tif by Si-Ting Huang (5591432)

“…Recombinant IL-18 also decreased the expression of TRPA1, IL-4, and TSLP.</p>Discussion<p>These findings suggested that the absence of Nlrp3 aggravated DNFB-induced chronic itch by exacerbating type 2 immunity in the skin and enhancing the IL-4/TSLP-TRPA1 axis, potentially driven by reduced IL-18 levels.…”

Image 1_Tanyu Tongzhi Formula relieves the progression of atherosclerotic plaque through lipid regulation and anti-inflammatory effects.jpeg by Tingting Chen (111216)

“…It decreased the serum levels of lipids and pro-inflammatory mediators (IL-6 and IL-1β) in AS mice. …”

Table_1_Baicalin enhances antioxidant, inflammatory defense, and microbial diversity of yellow catfish (Pelteobagrus fulvidraco) infected with Aeromonas hydrophila.DOCX by Pupu Yan (19710400)

“…Additionally, baicalin at an appropriate dosage was found to increase levels of SOD, GSH, CAT, ACP, and AKP in yellow catfish (P < 0.05), while simultaneously decreasing MDA accumulation and the mRNA expression of inflammatory markers such as Keap1, IL1, IFN-γ, and TNF-α, (P < 0.05). …”

Image 2_NLRP3 deficiency aggravated DNFB-induced chronic itch by enhancing type 2 immunity IL-4/TSLP-TRPA1 axis in mice.tif by Si-Ting Huang (5591432)

“…Recombinant IL-18 also decreased the expression of TRPA1, IL-4, and TSLP.</p>Discussion<p>These findings suggested that the absence of Nlrp3 aggravated DNFB-induced chronic itch by exacerbating type 2 immunity in the skin and enhancing the IL-4/TSLP-TRPA1 axis, potentially driven by reduced IL-18 levels.…”

Image 5_NLRP3 deficiency aggravated DNFB-induced chronic itch by enhancing type 2 immunity IL-4/TSLP-TRPA1 axis in mice.tif by Si-Ting Huang (5591432)

“…Recombinant IL-18 also decreased the expression of TRPA1, IL-4, and TSLP.</p>Discussion<p>These findings suggested that the absence of Nlrp3 aggravated DNFB-induced chronic itch by exacerbating type 2 immunity in the skin and enhancing the IL-4/TSLP-TRPA1 axis, potentially driven by reduced IL-18 levels.…”