Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Mechanistically, compound <b>E35</b> markedly decreased the expression of Skp2, as well as increased the expression of its substrates p21 and p27. …”

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Mechanistically, compound <b>E35</b> markedly decreased the expression of Skp2, as well as increased the expression of its substrates p21 and p27. …”

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Mechanistically, compound <b>E35</b> markedly decreased the expression of Skp2, as well as increased the expression of its substrates p21 and p27. …”

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Mechanistically, compound <b>E35</b> markedly decreased the expression of Skp2, as well as increased the expression of its substrates p21 and p27. …”

<i>Stenotrophomonas</i> sp. SI-NJAU‑1 and Its Mutant Strain with Excretion-Ammonium Capability Promote Plant Growth through Biological Nitrogen Fixation by Mengjia Zhou (4330429)

“…Deletion of <i>gln K</i> but not <i>gln B</i> in SI-NJAU-1 reduced the activity of glutamine synthetase (GS) and the unadenylylated GS and the content of glutamine, which led to ammonium secretion outside and significantly increased the biomass of barley. This work expands the scope of associative nitrogen-fixing endophytes, affirming their potential for plant growth promotion.…”

Participants diagram of the study. by Nirmal Gautam (10031682)

“…Moreover, non-consumption of fatty foods and outdoor activities were found to be associated with a decrease in obesity by respectively. However, non-consumption of fruits and vegetables and maternal BMI were significantly correlated with an increased risk of obesity in children () and adolescents () respectively.…”

Participants inclusion and exclusion criteria. by L. Cinnamon Bidwell (7069772)

“…<div><p>Background</p><p>As cannabis legalization continues to spread across the United States, average Δ⁹-tetrahydrocannabinol concentrations in recreational products have significantly increased, and no prior study has evaluated effective treatments to reduce cannabis use among high potency cannabis users. …”

Mucosal turnover in the duodenum and the jejunum following different diets at T1 and T2 post-weaning periods. by Marcella Massimini (5678543)

“…<p>IHC images (top row) showing a significant decrease in the number of cleaved-caspase-3 positive cells observed at T2 in the jejunum following PRE/PRO supplemented diet (B_20x) and an increase in Ki-67 positive cells following PRO supplementation (D_20x), compared to CTR (A and C, respectively_20x). …”

Supporting datasets for all figures. by Matthew Drill (22258391)

“…Inhibition of P2X7R with small molecule antagonist AZ10606120, for 72 hours significantly decreased U251 cell number (p < 0.0001), and significantly increased tumour cell death, as evidenced by increased LDH release (p < 0.001). …”

Patients outcome. by Loïc Duron (6433634)

“…Mean total medical costs decreased by €814 per patient (€3672 ± 2861 vs €4486 ± 3193), although this difference did not reach statistical significance (p = 0.23).…”

Summary of subgroup analysis results. by Junyin Pan (20700411)

“…The results showed that dietary anthocyanins significantly improved various lipid and glycemic markers:</p><p>HDL-C: increased by 0.05 mmol/L (95% CI: 0.01 to 0.10, p = 0.026), LDL-C: decreased by 0.18 mmol/L (95% CI: -0.28 to -0.08, p = 0.000), Triglycerides (TGs): reduced by 0.11 mmol/L (95% CI: -0.20 to -0.02, p = 0.021), Total cholesterol (TC): lowered by 0.34 mmol/L (95% CI: -0.49 to -0.18, p = 0.000), Fasting blood glucose (FBG): reduced by 0.29 mmol/L (95% CI: -0.46 to -0.12, p = 0.001), Glycated hemoglobin (HbA1c): decreased by 0.43% (95% CI: -0.74 to -0.13, p = 0.005). …”

Original study data. by Junyin Pan (20700411)

“…The results showed that dietary anthocyanins significantly improved various lipid and glycemic markers:</p><p>HDL-C: increased by 0.05 mmol/L (95% CI: 0.01 to 0.10, p = 0.026), LDL-C: decreased by 0.18 mmol/L (95% CI: -0.28 to -0.08, p = 0.000), Triglycerides (TGs): reduced by 0.11 mmol/L (95% CI: -0.20 to -0.02, p = 0.021), Total cholesterol (TC): lowered by 0.34 mmol/L (95% CI: -0.49 to -0.18, p = 0.000), Fasting blood glucose (FBG): reduced by 0.29 mmol/L (95% CI: -0.46 to -0.12, p = 0.001), Glycated hemoglobin (HbA1c): decreased by 0.43% (95% CI: -0.74 to -0.13, p = 0.005). …”

S2 File - by Junyin Pan (20700411)

“…The results showed that dietary anthocyanins significantly improved various lipid and glycemic markers:</p><p>HDL-C: increased by 0.05 mmol/L (95% CI: 0.01 to 0.10, p = 0.026), LDL-C: decreased by 0.18 mmol/L (95% CI: -0.28 to -0.08, p = 0.000), Triglycerides (TGs): reduced by 0.11 mmol/L (95% CI: -0.20 to -0.02, p = 0.021), Total cholesterol (TC): lowered by 0.34 mmol/L (95% CI: -0.49 to -0.18, p = 0.000), Fasting blood glucose (FBG): reduced by 0.29 mmol/L (95% CI: -0.46 to -0.12, p = 0.001), Glycated hemoglobin (HbA1c): decreased by 0.43% (95% CI: -0.74 to -0.13, p = 0.005). …”

Forest plots comparing demographic factors within SARS-CoV-2 variant waves. by Rebecca M. Cantu (19787070)

“…Confidence intervals that do not cross 1 on the x-axis are considered significant, with higher numbers associated with increased chances for hospitalization and lower numbers with decreased chances for hospitalization.…”

Graphical output of results from movement counts data modeled as a function of treatment levels, temperature ranges, and time discretized into 3-hour categories. by Kevin O. Ochwedo (11032248)

Graphical output of results from movement counts data modeled as a function of treatment levels, week, and time discretized into 3-hour categories. by Kevin O. Ochwedo (11032248)

Accuracy on the ERAM task. by Daisung Jang (16781451)

“…This suggests that in general having higher estrogen levels increases accuracy, but that higher-than-usual estrogen at a given time decreases it. …”

Identification of Key Genes. by Chen Wang (88408)

CFU counts and Gram stain of lung tissues 2 days following the injury. by Ghaith A. Bahader (21387572)

“…There was a significant decrease in the TBI/H + GM-CSF group in comparison to TBI/H+saline group (†p < 0.05). …”

Biotransformation Dynamics and Products of Cyanobacterial Secondary Metabolites in Surface Waters by Xuejian Wang (532695)

“…Increasing the initial cyanopeptide concentration lengthened the lag time and decreased their initial removal, supporting inhibitory effects of cyanopeptides toward enzymes involved in their own transformation. …”