<b>Selective Reduction of Ca</b>^{<strong>2+</strong>}<b>-Independent Phospholipase A</b>_{<strong>2</strong>}<b>b</b><b> (iPLA</b>_{<strong>2</strong>}<b>b... by Abdulaziz Almutairi (9584768)

“…What is the specific question(s) we wanted to answer?</b></p><p dir="ltr">· Does MF-iPLA₂b-derived lipid signaling impact diabetes development ?…”

Image 3_MR-guided focused ultrasound thalamotomy modulates cerebello-thalamo-cortical tremor network in essential tremor patients.png by Li Jiang (120930)

“…Conversely, a significant positive correlation was observed in the frontal orbital cortex, right insular cortex, temporal pole, hippocampus, left lingual gyrus, right cerebellar lobules IV/V, left cerebellar lobule VI, and vermis IV/V.…”

Table 1_MR-guided focused ultrasound thalamotomy modulates cerebello-thalamo-cortical tremor network in essential tremor patients.docx by Li Jiang (120930)

“…Conversely, a significant positive correlation was observed in the frontal orbital cortex, right insular cortex, temporal pole, hippocampus, left lingual gyrus, right cerebellar lobules IV/V, left cerebellar lobule VI, and vermis IV/V.…”

Image 2_MR-guided focused ultrasound thalamotomy modulates cerebello-thalamo-cortical tremor network in essential tremor patients.png by Li Jiang (120930)

“…Conversely, a significant positive correlation was observed in the frontal orbital cortex, right insular cortex, temporal pole, hippocampus, left lingual gyrus, right cerebellar lobules IV/V, left cerebellar lobule VI, and vermis IV/V.…”

Image 1_MR-guided focused ultrasound thalamotomy modulates cerebello-thalamo-cortical tremor network in essential tremor patients.jpeg by Li Jiang (120930)

“…Conversely, a significant positive correlation was observed in the frontal orbital cortex, right insular cortex, temporal pole, hippocampus, left lingual gyrus, right cerebellar lobules IV/V, left cerebellar lobule VI, and vermis IV/V.…”

Data Sheet 2_Triterpenes in breast cancer: a systematic review of preclinical evidence in rodents.xlsx by Alexandra Prodea (22617710)

“…The toxicity assessment revealed that triterpenes have in general, insignificant or absent toxicity, with only a small number of studies reporting serious side effects such as leukopenia, hepatotoxicity and mortality at specific doses that were reversed in some cases by the use of carriers, which hold the potential to enhance the therapeutic effect of triterpenes while reducing their systemic toxicity.</p>Conclusion<p>We concluded that the current in vivo evidence does not support the clinical translation of triterpenes for the treatment of breast cancer due to methodological and clinical heterogeneity as well as the lack of toxicity data in a significant number of studies. …”

Data Sheet 1_Triterpenes in breast cancer: a systematic review of preclinical evidence in rodents.pdf by Alexandra Prodea (22617710)

“…The toxicity assessment revealed that triterpenes have in general, insignificant or absent toxicity, with only a small number of studies reporting serious side effects such as leukopenia, hepatotoxicity and mortality at specific doses that were reversed in some cases by the use of carriers, which hold the potential to enhance the therapeutic effect of triterpenes while reducing their systemic toxicity.</p>Conclusion<p>We concluded that the current in vivo evidence does not support the clinical translation of triterpenes for the treatment of breast cancer due to methodological and clinical heterogeneity as well as the lack of toxicity data in a significant number of studies. …”

Water bridges by Raman Jangra (19231711)

“…To delineate the structural role of water molecules in shaping the interactions between RNA and proteins, we comprehensively analyzed a dataset of 329 high-resolution crystal structures of RNA–protein complexes to identify water-mediated hydrogen-bonded contacts at the RNA–protein interface. …”

Data Sheet 1_Serum levels of per- and polyfluoroalkylated substances and methylation of DNA from peripheral blood.pdf by Hanane Omichessan (4991552)

“…Serum levels of PFOS and PFOA were measured by liquid chromatography coupled to tandem mass spectrometry.</p>Results<p>We found 64 CpG sites with significant hypomethylation or hypermethylation associated with increased levels of PFOA or PFOS (p-value_Bonferroni < 0.05). …”

Spatial variation and clgassification of anthropogenic soils formed by long-term “<i>Dorotsuke”</i> soil-dressing in Andosols of the Omiya Upland along the Arakawa River, Japan by Shokichi Wakabayashi (3872428)

“…The two anthropogenic horizons exceeded 50 cm in thickness with different soil textures, while one of the other two showed significant mixing with Andosol. The profiles exhibited a vertical attenuation of andic characteristics, including increased bulk density, decreased short-range-order mineral content, and reduced phosphate retention, from the buried Andosol up to the topsoil. …”

Figure 5 from Membrane-bound Heat Shock Protein mHsp70 Is Required for Migration and Invasion of Brain Tumors by Maxim Shevtsov (15023874)

“…<p>Application of Hsp70 inhibitors decreases the brain tumor cell migratory activity. …”

Data Sheet 1_Immunogenic cell death-related biomarkers in heart failure probed by transcriptome and single-cell sequencing.zip by Haoyue Wang (13138179)

“…In addition, the expression levels of CD163 and VSIG4 increased in subpopulations of monocytes and macrophages, whereas FPR1 showed a decreasing trend. RT-qPCR results confirmed significant down-regulation of CD163, FPR1, and VSIG4 in patients with HF and animal models.…”

TRIM16 mediates secretory autophagy in head and neck cancer-associated fibroblasts by Thuc Ly (12832686)

“…Using both a literature based, and an unbiased approach, we studied the molecular machinery involved in autophagosome trafficking in CAFs. …”

Image 7_Systemic immune inflammatory index and mortality in chronic kidney disease.tif by Yanshuang Ma (22176478)

“…Higher SII levels correlated with decreased survival and longevity. In CKD patients over 45 years, SII reliably predicted all-cause mortality (statistically significant) and was linked to cardiovascular and cancer deaths (not statistically significant).…”

Data Sheet 1_From court to community: a cost–benefit evaluation of a community sports programme for Arab women in Israel's multiethnic context.docx by Limor Dina Gonen (14258380)

“…Gains in mental well-being were observed but did not reach statistical significance (p = 0.09). …”

Image 2_Systemic immune inflammatory index and mortality in chronic kidney disease.tif by Yanshuang Ma (22176478)

“…Higher SII levels correlated with decreased survival and longevity. In CKD patients over 45 years, SII reliably predicted all-cause mortality (statistically significant) and was linked to cardiovascular and cancer deaths (not statistically significant).…”

Image 3_Systemic immune inflammatory index and mortality in chronic kidney disease.tif by Yanshuang Ma (22176478)

“…Higher SII levels correlated with decreased survival and longevity. In CKD patients over 45 years, SII reliably predicted all-cause mortality (statistically significant) and was linked to cardiovascular and cancer deaths (not statistically significant).…”

Table 1_Maintaining long-term frequent tea consumption could reduce the risk of cognitive decline: results from a 10-year longitudinal study.docx by Jie Huang (104235)

“…Consistently frequent tea drinkers had a 12% (HR:0.88, 95% CI: 0.77, 0.99) reduced risk of cognitive decline, whereas no significant association was observed for inconsistently frequent tea consumption (HR:0.98, 95% CI:0.91, 1.07) (P for trend < 0.001). …”

Data Sheet 1_Global burden of inflammatory bowel disease in children and adolescents, 1990–2021: trends, age-specific patterns and future projections.zip by Hai-Qing Tan (22173514)

“…</p>Results<p>Globally, the incidence of IBD among children and adolescents remained stable (EAPC = −0.03%, 95% CI: −0.44–0.38), although marked regional disparities were observed. The incidence rates were stable or declined in high-income countries (e.g., high-income North America: EAPC = −1.07, 95% CI: −1.82–−0.32), whereas industrializing regions showed significant increases (e.g., East Asia: EAPC = 2.01, 95% CI: 1.02–3.19). …”

Data Sheet 4_Efficacy and safety of Shuxuening injection in intracerebral hemorrhage: a systematic review and meta-analysis.pdf by Wenting Song (822582)

“…Compared with the control group, the treatment group demonstrated better performance in reducing neurological impairment score [SMD = −0.99, 95% CI −1.24, −0.73], improving overall efficacy [RR = 1.22, 95% CI 1.14, 1.30] and ADL score [SMD = 2.01, 95%CI 1.55, 2.46], as well as decreasing the cerebral hematoma volume [MD = −6.98, 95% CI −8.76, −5.20] and cerebral edema volume [MD = −3.67, 95%CI -5.27, −2.06], with statistically significant differences observed. …”