Discovery of NP3-742: A Structurally Diverse NLRP3 Inhibitor Identified through an Unusual Phenol Replacement by Juraj Velcicky (2201350)

“…Initial indole analog <b>7</b> demonstrated a robust in vivo IL-1β inhibition, but also a significant hERG inhibition. Decreasing lipophilicity led to the discovery of <b>NP3-742</b>, demonstrating a favorable overall profile including diminished hERG inhibition and in vivo efficacy in a mouse peritonitis model.…”

Discovery of NP3-742: A Structurally Diverse NLRP3 Inhibitor Identified through an Unusual Phenol Replacement by Juraj Velcicky (2201350)

“…Initial indole analog <b>7</b> demonstrated a robust in vivo IL-1β inhibition, but also a significant hERG inhibition. Decreasing lipophilicity led to the discovery of <b>NP3-742</b>, demonstrating a favorable overall profile including diminished hERG inhibition and in vivo efficacy in a mouse peritonitis model.…”

KEGG pathway enrichment bubble map of the top 20 DAPs. by Caijin Chen (3107787)

Age-related correlation of PBMCs percentages. by Juliane F. Tampé (19976538)

Supplementary Figs 1–7. by Juliane F. Tampé (19976538)

Age-dependent expression of <i>ANXA1</i> gene in monocytes and their subtypes. by Juliane F. Tampé (19976538)

Changes in the active H3K27ac and repressive H3K27me3 histone marks among Vasa2+/Piwi1+ and all cells in fed, starved, and refed juvenile polyps. by Eudald Pascual-Carreras (12115380)

“…Between fed, T_5ds and T_20ds timepoints, MFI levels of H3K27ac progressively and significantly decreased while levels H3K27me3 (M) did not change significantly (N). …”

Age-related correlation of PBMCs percentages in comparison between males and females. by Juliane F. Tampé (19976538)

“…<p>Only cells/groups with significant p-values are shown. Additional data are presented in S1 Fig 5 in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0300946#pone.0300946.s001" target="_blank">S1 File</a>. …”

Dynamics of EGFP and mRFP fluorescence in infected cells under different heat shock conditions. by Enrique Paz-Cortés (20988196)

Risk of bias summary. by Duc Tran Quang (20564967)

“…The observed decrease in body weight could be partially attributed to factors influencing energy balance, as evidenced by the significantly lower mean calorie intake at the end of the intervention (1694.71 kcal/day, 95% CI: 1498.57–1890.85) compared to the baseline intake (2000.64 kcal/day, 95% CI: 1830–2172.98), despite the absence of intentional efforts to restrict energy intake by the participants. …”

Criteria for study selection. by Duc Tran Quang (20564967)

“…The observed decrease in body weight could be partially attributed to factors influencing energy balance, as evidenced by the significantly lower mean calorie intake at the end of the intervention (1694.71 kcal/day, 95% CI: 1498.57–1890.85) compared to the baseline intake (2000.64 kcal/day, 95% CI: 1830–2172.98), despite the absence of intentional efforts to restrict energy intake by the participants. …”

Treatment of cancer cells with vitamin D3 induced death <i>a.</i> by Vidya G. Bettada (22208808)

Effect of alkali-stress to chlorophyll fluorescence parameters compared to control treatment. by Zeyu Jiang (5094320)

Effect of alkali-stress on photosynthetic pigments of hemp seedlings compared to control treatment. by Zeyu Jiang (5094320)

Effect of alkali-stress on physiological indices of antioxidant system compared to control treatment. by Zeyu Jiang (5094320)

Baseline characteristics and oxidative profiling. by Summan Thahiem (20988319)

Effect of Viscosol on upstream mediators of inflammasomes activation, PTP1B and inflammasome complexes. by Summan Thahiem (20988319)

The expression profile of lipogenic genes, oxidative stress mediators as well as UPR^ER and mitochondrial stress markers. by Summan Thahiem (20988319)

Effect of Viscosol on the expression of inflammatory cytokines, chemokines as well as cell death pathways. by Summan Thahiem (20988319)

“…The results shown are represented as mean ±  SD. Significant differences compared to control (****<i>p</i> < 0.0001, ***<i>p</i> < 0.0001, **<i>p</i> < 0.01 and * <i>p</i> <  0.05; two-wayANOVA and Tukey’s test).…”

Mortality dataset used in analysis. by Samuel Sendagala (21417164)

“…<div><p>Background</p><p>Uganda reported a significant reduction in the mortality rate of children under 5 years of age, from 146/1,000 live births in 2000–42/1,000 live births in 2021. …”