Discovery of an Orally Active PDE1 Inhibitor for Disease-Modifying Treatment of Postmenopausal Osteoporosis via Dual Anabolic-Antiresorptive Mechanisms حسب Farman M. Abbasi (22318766)

"…In ovariectomized mice, <b>5cc</b> administration (5 mg/kg) improved the trabecular microarchitecture, bone mineral density, and strength, at levels comparable to teriparatide, while significantly reducing bone resorption markers. With 13.57% oral bioavailability and selectivity for PDE1A1 (32% inhibition at 500 nM), <b>5cc</b> offers an innovative therapeutic candidate for PMO with a dual anabolic-antiresorptive profile and oral efficacy, warranting further clinical development.…"

Supplementary file 1_Ivarmacitinib reduces the need for adding/escalating medications in moderate-to-severe rheumatoid arthritis patients: a post hoc analysis from a phase III tria... حسب Huaxiang Liu (322464)

"…</p>Conclusion<p>Ivarmacitinib significantly reduces the need for adding/escalating medications compared to placebo, thereby potentially decreasing treatment burden. …"

FAT1 interacts with the E3 ligase MIB2. حسب Rui Li (4631)

Molecular Logic Gate for Sensing pH/Peroxynitrite with Potential Applications in Cisplatin Treatment حسب Lifang Guo (1460884)

"…With this probe, the significant roles of pH and ONOO^– in cisplatin treatment are disclosed, in which the cell account shows a dramatic reduction accompanied by decreased pH and upregulated ONOO^– levels. …"

Primer pairs for RT-qPCR. حسب Yoichi Kurokawa (22290520)

"…Conversely, exposure to endogenous prooxidants (dopamine and adrenaline), certain food-derived polyphenols (chrysin and 3-<i><i>O</i></i>-methylquercetin), or 1,2-naphthoquinone led to a significant decrease (<0.5-fold) in Rmst expression. …"

RT-qPCR data tables. حسب Yoichi Kurokawa (22290520)

"…Conversely, exposure to endogenous prooxidants (dopamine and adrenaline), certain food-derived polyphenols (chrysin and 3-<i><i>O</i></i>-methylquercetin), or 1,2-naphthoquinone led to a significant decrease (<0.5-fold) in Rmst expression. …"

Inc exhibits key properties of a Cul3 adaptor in neurons in vivo. حسب Qiuling Li (390393)

"…Neuronal <i>Cul3</i> RNAi decreases <i>Cul3</i> transcript levels but does not significantly alter those of <i>inc</i>. …"

Citation patterns of Cochrane Reviews and other systematic reviews: a bibliometric analysis حسب Louise Olsbro Rosengaard (20439098)

"…The time window in which systematic reviews received citations has been progressively decreasing, possibly indicating a trend toward quicker recognition and uptake of these reviews within the academic community. …"

Data Sheet 1_Adherence to a “MediterrAsian” diet is associated with weight loss-independent improvements in liver fat and lipid profile, but not glucoregulation or inflammation: se... حسب Yu Chung Chooi (18968382)

"…</p>Results<p>Body weight, total body fat, visceral and subcutaneous adipose tissues, and liver fat decreased significantly after the intervention, in tandem with improvements in markers of glucose and lipid metabolism and inflammation. …"

Certainty of affect predicted by valence and low, medium, and, high trait emotional clarity Predicted certainty of knowing how you feel in a trial, as predicted by the subject’s st... حسب Anthony G. Vaccaro (5964368)

Prognostic indicators and survival rates in vulvar cancer: insights from a retrospective study حسب Tharinee Rahong (21020147)

"…Multivariate analysis indicated that coexisting lesions such as Paget’s disease and lichen sclerosus, positive lymphovascular space invasion (LVSI), pelvic or para-aortic lymph node involvement, and positive p53 expression were significantly linked to reduced PFS. Additionally, a tumour size greater than 4 cm was associated with decreased OS. …"

Categorisation of districts based on type of correlation observed and results of Moran’s local test for spatial correlation of coefficients and lags. حسب Gabriel Carrasco-Escobar (794055)

Trends over 10 years (2011–2021) in clinical characteristics of children with severe acute malnutrition admitted at Moyo NRU. حسب Mphatso Nancy Chisala (20477275)

Basic features of microtopography. حسب Qingping Gou (22641045)

"…The results showed that: the difference of shallow soil moisture in different microtopographies on a slope surface was not significant, the difference of deep soil moisture was significant, and the soil moisture overuse was the largest in the gully (GU), amounting to 386.36 mm, and the smallest in the ephemeral gully (EG) (131.02 mm); the GU, the sink hole (SH), and the scarp (SC) showed a trend of decreasing and then increasing with the increase of soil depth, and the platform (PL) has little overall trend of change in soil moisture with the increase of soil depth, and the soil moisture of US and EG shows the trend of “decreasing-then increasing-then decreasing” with the increase of soil depth. …"

Soil bulk density of different microtopographies. حسب Qingping Gou (22641045)

"…The results showed that: the difference of shallow soil moisture in different microtopographies on a slope surface was not significant, the difference of deep soil moisture was significant, and the soil moisture overuse was the largest in the gully (GU), amounting to 386.36 mm, and the smallest in the ephemeral gully (EG) (131.02 mm); the GU, the sink hole (SH), and the scarp (SC) showed a trend of decreasing and then increasing with the increase of soil depth, and the platform (PL) has little overall trend of change in soil moisture with the increase of soil depth, and the soil moisture of US and EG shows the trend of “decreasing-then increasing-then decreasing” with the increase of soil depth. …"

Trends over 10 years in children with severe acute malnutrition admitted at Moyo NRU. حسب Mphatso Nancy Chisala (20477275)

Distribution of study areas. حسب Jie Zhang (64655)

"…(main findings) The results show the following: (1) the primary term of government innovation preferences has a positive effect on the ecological resilience of resource-based cities, and the secondary term has a negative effect, with a decreasing marginal effect. …"

Descriptive statistics of variables. حسب Jie Zhang (64655)

"…(main findings) The results show the following: (1) the primary term of government innovation preferences has a positive effect on the ecological resilience of resource-based cities, and the secondary term has a negative effect, with a decreasing marginal effect. …"

Code. حسب Jie Zhang (64655)

"…(main findings) The results show the following: (1) the primary term of government innovation preferences has a positive effect on the ecological resilience of resource-based cities, and the secondary term has a negative effect, with a decreasing marginal effect. …"

Schematic of the conclusions. حسب Jie Zhang (64655)

"…(main findings) The results show the following: (1) the primary term of government innovation preferences has a positive effect on the ecological resilience of resource-based cities, and the secondary term has a negative effect, with a decreasing marginal effect. …"