Identification of narciclasine as a novel NRF2 inhibitor by Hoang Hai Ngo (20564072)

“…Finally, we observed that administration of narciclasine significantly decreased the growth of A549 xenografts. …”

Image_2_A sexually dimorphic signature of activity-dependent BDNF signaling on the intrinsic excitability of pyramidal neurons in the prefrontal cortex.TIF by Kaijie Ma (6065156)

“…Notably, significantly decreased thresholds of action potentials were observed in male BDNF^+/Met mice, but not in female BDNF^+/Met mice. …”

Image_1_A sexually dimorphic signature of activity-dependent BDNF signaling on the intrinsic excitability of pyramidal neurons in the prefrontal cortex.TIF by Kaijie Ma (6065156)

“…Notably, significantly decreased thresholds of action potentials were observed in male BDNF^+/Met mice, but not in female BDNF^+/Met mice. …”

[A] Histopathological images of pancreas, liver, kidney, and heart tissues from the studied rat groups, stained with H&E. by Mohamed Lotfy (18599184)

“…The values are presented as mean ± SEM. ^# Indicates significant difference (P ≤ 0.05) between the untreated diabetic group and the control group. * Indicates a significant difference (P ≤ 0.05) between the C. lancifolius-treated or crocin-treated diabetic group and the untreated diabetic group. …”

Data Sheet 1_Pregnancy hormones increase cardiac capillary density via the PGC-1α/ERRα/VEGF pathway in cardiomyocytes.docx by Michael Hesse (439701)

“…The proportion of proliferating cardiac cells and ECs was significantly increased after 14 days of treatment. Mechanistically, we identified activation of the PGC-1α/ERRα signaling pathway and upregulation of its downstream target VEGF-A. …”

Table 1_RfaH contributes to maximal colonization and full virulence of hypervirulent Klebsiella pneumoniae.docx by Yichuan Qiu (13302081)

“…We found that the ΔrfaH mutant led to a significantly decreased mortality of K. pneumoniae in a mouse intraperitoneal infection model. …”

Data Sheet 1_Effect of NR1D1 on the proliferation and differentiation of yak skeletal muscle satellite cells.pdf by Yuqi Zhe (20107152)

“…Eventually, we successfully constructed a primary cell line of yak muscle satellite cells. …”

Table 1_Longitudinal changes in vitamin D during twin pregnancy: association with maternal–neonatal outcomes.docx by Zhentong Dai (22629206)

“…The RCS revealed an L-shaped VD-sPTB risk relationship. Each 1 ng/mL VD decrease increased sPTB risk by 14.94% (OR = 0.87). …”

Data Sheet 1_Clinical pharmacist interventions in medication review for medication optimization in older hospitalized adults with mental disorders and somatic comorbidities: eviden... by Matej Stuhec (5643284)

“…</p>Results<p>The study included 100 inpatients with a mean age of 78.1 years (SD = 6.78). The total number of medications decreased by 6.6% (from 1,144 to 1,068; p < 0.001), with an acceptance rate of 59.2%. …”

Supplementary file 1_Changes of potential shorty-chain fatty acids producing bacteria in the gut of patients with spinal cord injury: a systematic review and meta-analysis.zip by Zaowei Zhong (20796020)

“…The search period was from inception to March 31, 2024. We reported standardized mean differences (d) with 95% confidence intervals (CI) and used funnel plots and Egger tests to assess publication bias. …”

Table 1_Propolis supplementation on inflammatory and oxidative stress biomarkers in adults: a systematic review and meta-analysis of randomized controlled trials.docx by Hossein Bahari (16704768)

“…This meta-analysis revealed that propolis consumption led to a significant decrease in C-reactive protein (CRP) (WMD: –1.23; 95%CI: –1.76, –0.69; p < 0.001), Interleukin-6 (IL-6) (WMD: –1.52; 95%CI: –2.10, –0.93; p < 0.001), Tumor necrosis factor-α (WMD: –1.15; 95%CI: –1.75, –0.55; p < 0.001), and Monocyte chemoattractant protein-1 (MCP-1) (WMD: –35.33; 95%CI: –50.28, –20.37; p < 0.001), and a significant increase in total antioxidant capacity (TAC) (WMD: 0.32; 95%CI: 0.12, 0.51; p = 0.001), Glutathione (GSH) (WMD: 4.71; 95%CI: 3.17, 6.25; p < 0.001), and Glutathione peroxidase (GPx) (WMD: 44.75; 95%CI: 5.10, 84.40; p = 0.02). …”

PRMT5 regulates alternative splicing landscape under hypoxia. by Srinivas Abhishek Mutnuru (22513457)

“…Error bars, mean ± SEM; two-tailed <i>t</i> test, one-way ANOVA. …”

Digitized maps of vascular plant species distributions in Denmark in the early 20th century by Ditte Marie Christiansen (12182972)

“…., natural history museums, and make up significant untapped resources for insights into past biodiversity patterns. …”

Image 1_Changes in insulin resistance and other metabolic parameters during home quarantine amid the COVID-19 pandemic among the general population.jpeg by Yuting Zhang (337082)

“…Compared to before home quarantine, the TyG (6.80 ± 0.58 vs. 6.83 ± 0.58, p < 0.001), TyG-BMI (158.30 ± 31.92 vs. 159.48 ± 31.73, p < 0.001), and TyG-WC (533.53 ± 103.15 vs. 535.78 ± 103.65, p = 0.039) increased significantly after the home quarantine. Besides, glucose, lymphocyte, and platelet decreased significantly while BMI, systolic blood pressure, diastolic blood pressure, pulse, total cholesterol, triglyceride, high-density lipoprotein, low-density lipoprotein, uric acid, red blood cell, and monocyte also increased significantly after home quarantine (all p < 0.05).…”

Table1_Tle6 deficiency in male mice led to abnormal sperm morphology and reduced sperm motility.docx by Kousuke Kazama (19937214)

“…In addition, Tle6^+/− mice exhibited a significant increase in serum testosterone levels compared to wild-type mice. …”

Data Sheet 1_Investigating the impact of microcalcification size and volume on collagenous matrix and tissue mechanics using a tissue-engineered atherosclerotic cap model.xlsx by Imke L. Jansen (22089944)

“…To mimic human microcalcification size and volume, hydroxyapatite microparticles, in two size ranges (diameter up to 5 μm or up to 50 μm) and two volumes (1 v/v% and 5 v/v%) were incorporated homogenously throughout the tissue-engineered model. 5 v/v% of particles caused a significant lowering of the mechanical properties as was shown by a decrease in stiffness and ultimate tensile stress under uniaxial tensile loading. …”

Supplementary Material for: Role of melatonin in intestinal mucosal injury induced by chronic restraint stress in mice by figshare admin karger (2628495)

“…Results: Mice subjected to restraint stress presented elevated CORT and NE levels of 141.41% and 151.24%, respectively, and a decreased plasma MT content of 37.12%. Consistent with the decrease in MT levels, we observed a reduction in antioxidant ability and autophagic proteins and increased apoptotic protein levels in the gut, resulting in injury to the intestinal mucosa, which manifested as reductions in the villus height and the V/C ratio; the number of goblets; the number of mast and PCNA-positive cells; and the expression of tight junction proteins (ZO-1, occludin and claudin-1). …”

Supplementary Material for: Acute myelin oligodendrocyte glycoprotein (MOG)-IgG optic neuritis without optic nerve enhancement by Jeyanathan B. (20374227)

“…While acute MOG-ON usually presents with optic nerve enhancement, recognizing atypical presentations is critical in accurate diagnosis and effective management. Case Presentation: We herein present a case of a 67-year-old woman presenting with sudden decrease in vision in the right eye. …”

Supplementary file 1_Global, regional, and national burdens of MDR-TB attributable to smoking from 1990 to 2021 with a prediction from 2022 to 2050.docx by Du Dan (22274296)

“…Objective<p>The aim was to offer a comprehensive epidemiological assessment of the global prevalence and the smoking-related Multidrug-resistant tuberculosis (MDR-TB) disease burden from 1990 to 2021 and to forecast the trends in smoking burden over three decades.</p>Methods<p>We compared the burden of smoking-related MDR-TB and temporal trends by gender, age, socio-demographic index (SDI), region, and country. …”

Table1_Bidirectional two-sample Mendelian randomization analysis investigates causal associations between cathepsins and inflammatory bowel disease.DOCX by Na Wang (193263)

“…</p>Results<p>The forward MR analyses showed no significant association between cathepsins and IBD. …”