Synthesis process of Kylo-0603. by Xueqin lu (22250795)

“…The non-alcoholic steatohepatitis (NASH) activity score (NAS) demonstrated a significant reduction of up to 3.7 points (P < 0.0001), while the fibrosis score decreased by 0.6 points (P < 0.05). …”

ESI-HRMS spectra for Kylo-0603. by Xueqin lu (22250795)

“…The non-alcoholic steatohepatitis (NASH) activity score (NAS) demonstrated a significant reduction of up to 3.7 points (P < 0.0001), while the fibrosis score decreased by 0.6 points (P < 0.05). …”

Effects of Kylo-0603 on the expression of related genes of the MASH mouse models. by Xueqin lu (22250795)

General procedure for the synthesis of B. by Xueqin lu (22250795)

Parameters used in the simulations. by Yongfeng Zhu (7361045)

“…This study introduces key parameters—aspect ratio (Ω), sphericity (S), and equivalent diameter (Dₑ)—into a modified Hertz-based contact model to conduct a multiscale study using contact mechanics theory and the discrete element method (DEM). …”

Two ellipsoidal particles in contact. by Yongfeng Zhu (7361045)

“…This study introduces key parameters—aspect ratio (Ω), sphericity (S), and equivalent diameter (Dₑ)—into a modified Hertz-based contact model to conduct a multiscale study using contact mechanics theory and the discrete element method (DEM). …”

Different contact patterns for two ellipsoids. by Yongfeng Zhu (7361045)

“…This study introduces key parameters—aspect ratio (Ω), sphericity (S), and equivalent diameter (Dₑ)—into a modified Hertz-based contact model to conduct a multiscale study using contact mechanics theory and the discrete element method (DEM). …”

Effects of Kylo-0603 on body weight, organ weight, and body fat content. by Xueqin lu (22250795)

The body weight and cholesterol levels of the mice were recorded before the administration of the drug. by Xueqin lu (22250795)

The trends of cholesterol metabolism-related gene expression in liver tissue. by Xueqin lu (22250795)

Hazard ratios for Sex across age based on unadjusted (A) and adjusted (B) Cox model. Note: shaded areas representing the 95% confidence intervals; green bars indicating the distrib... by Hui Ouyang (245739)

Summary statistics. by Stephan Dietrich (6979985)

“…In this paper, we apply a novel approach to try and address this issue. …”

Deviatoric stress-strain curves of numerical samples composed of elongated ellipsoids with different particle morphologies and particle sizes. by Yongfeng Zhu (7361045)

Numerical samples composed of elongated ellipsoids before and after triaxial compression. by Yongfeng Zhu (7361045)

The force chain distributions of different numerical samples composed of elongated ellipsoids with different particle morphologies and particle sizes before shearing and after load... by Yongfeng Zhu (7361045)

Different ellipsoidal particles with De = 6.30 mm used in the discrete element simulations. by Yongfeng Zhu (7361045)

Kylo-0603’s EC50 & tissue levels. by Xueqin lu (22250795)

DIO Mice Liver Staining. by Xueqin lu (22250795)

The Fibrosis scoring by Sirius Red staining and SHG/TPEF. by Xueqin lu (22250795)

Pharmacological efficacy of Kylo-0603 in MASH mouse models (F2 ~ 3). by Xueqin lu (22250795)