Discovery of an Orally Active PDE1 Inhibitor for Disease-Modifying Treatment of Postmenopausal Osteoporosis via Dual Anabolic-Antiresorptive Mechanisms by Farman M. Abbasi (22318766)

“…In ovariectomized mice, <b>5cc</b> administration (5 mg/kg) improved the trabecular microarchitecture, bone mineral density, and strength, at levels comparable to teriparatide, while significantly reducing bone resorption markers. With 13.57% oral bioavailability and selectivity for PDE1A1 (32% inhibition at 500 nM), <b>5cc</b> offers an innovative therapeutic candidate for PMO with a dual anabolic-antiresorptive profile and oral efficacy, warranting further clinical development.…”

Discovery of an Orally Active PDE1 Inhibitor for Disease-Modifying Treatment of Postmenopausal Osteoporosis via Dual Anabolic-Antiresorptive Mechanisms by Farman M. Abbasi (22318766)

“…In ovariectomized mice, <b>5cc</b> administration (5 mg/kg) improved the trabecular microarchitecture, bone mineral density, and strength, at levels comparable to teriparatide, while significantly reducing bone resorption markers. With 13.57% oral bioavailability and selectivity for PDE1A1 (32% inhibition at 500 nM), <b>5cc</b> offers an innovative therapeutic candidate for PMO with a dual anabolic-antiresorptive profile and oral efficacy, warranting further clinical development.…”

Discovery of an Orally Active PDE1 Inhibitor for Disease-Modifying Treatment of Postmenopausal Osteoporosis via Dual Anabolic-Antiresorptive Mechanisms by Farman M. Abbasi (22318766)

“…In ovariectomized mice, <b>5cc</b> administration (5 mg/kg) improved the trabecular microarchitecture, bone mineral density, and strength, at levels comparable to teriparatide, while significantly reducing bone resorption markers. With 13.57% oral bioavailability and selectivity for PDE1A1 (32% inhibition at 500 nM), <b>5cc</b> offers an innovative therapeutic candidate for PMO with a dual anabolic-antiresorptive profile and oral efficacy, warranting further clinical development.…”

RSA results across a broader frequency band (0.1–150 Hz). by Pengcheng Lv (7609706)

“…<p><b>(A)</b> For the translation epochs from good trials, the similarity of Same Context was significantly greater than the similarity of Different Context in HC. …”

Supplementary file 1_Ivarmacitinib reduces the need for adding/escalating medications in moderate-to-severe rheumatoid arthritis patients: a post hoc analysis from a phase III tria... by Huaxiang Liu (322464)

“…</p>Conclusion<p>Ivarmacitinib significantly reduces the need for adding/escalating medications compared to placebo, thereby potentially decreasing treatment burden. …”

Molecular Logic Gate for Sensing pH/Peroxynitrite with Potential Applications in Cisplatin Treatment by Lifang Guo (1460884)

“…With this probe, the significant roles of pH and ONOO^– in cisplatin treatment are disclosed, in which the cell account shows a dramatic reduction accompanied by decreased pH and upregulated ONOO^– levels. …”

Primer pairs for RT-qPCR. by Yoichi Kurokawa (22290520)

“…Conversely, exposure to endogenous prooxidants (dopamine and adrenaline), certain food-derived polyphenols (chrysin and 3-<i><i>O</i></i>-methylquercetin), or 1,2-naphthoquinone led to a significant decrease (<0.5-fold) in Rmst expression. …”

RT-qPCR data tables. by Yoichi Kurokawa (22290520)

“…Conversely, exposure to endogenous prooxidants (dopamine and adrenaline), certain food-derived polyphenols (chrysin and 3-<i><i>O</i></i>-methylquercetin), or 1,2-naphthoquinone led to a significant decrease (<0.5-fold) in Rmst expression. …”

Supplementary Material for: Trends in the Incidence of Rare Eyelid Malignancies: A SEER-Based Study (2000–2021) by figshare admin karger (2628495)

“…For SGC; ARIMA (0,0,0) model demonstrated a decline in IR in 2011 (IR = 0.0192), increase until 2019, then decrease in 2021 (IR = 0.0246), with a predicted 10-year decrease to 0.026 (95% PI: 0.019–0.032). …”

Table 1_Effects of a community pharmacy-based structured medication review on drug-related problems in all-comers with polypharmacy: a randomized, controlled, double-blind, paralle... by Thorsten Bischof (19848696)

“…Furthermore, a medication review decreased the mean number of active ingredients by ~9% in the intervention group compared to the control group.…”

Citation patterns of Cochrane Reviews and other systematic reviews: a bibliometric analysis by Louise Olsbro Rosengaard (20439098)

“…The time window in which systematic reviews received citations has been progressively decreasing, possibly indicating a trend toward quicker recognition and uptake of these reviews within the academic community. …”

Categorisation of districts based on type of correlation observed and results of Moran’s local test for spatial correlation of coefficients and lags. by Gabriel Carrasco-Escobar (794055)

Basic features of microtopography. by Qingping Gou (22641045)

“…The results showed that: the difference of shallow soil moisture in different microtopographies on a slope surface was not significant, the difference of deep soil moisture was significant, and the soil moisture overuse was the largest in the gully (GU), amounting to 386.36 mm, and the smallest in the ephemeral gully (EG) (131.02 mm); the GU, the sink hole (SH), and the scarp (SC) showed a trend of decreasing and then increasing with the increase of soil depth, and the platform (PL) has little overall trend of change in soil moisture with the increase of soil depth, and the soil moisture of US and EG shows the trend of “decreasing-then increasing-then decreasing” with the increase of soil depth. …”

Soil bulk density of different microtopographies. by Qingping Gou (22641045)

“…The results showed that: the difference of shallow soil moisture in different microtopographies on a slope surface was not significant, the difference of deep soil moisture was significant, and the soil moisture overuse was the largest in the gully (GU), amounting to 386.36 mm, and the smallest in the ephemeral gully (EG) (131.02 mm); the GU, the sink hole (SH), and the scarp (SC) showed a trend of decreasing and then increasing with the increase of soil depth, and the platform (PL) has little overall trend of change in soil moisture with the increase of soil depth, and the soil moisture of US and EG shows the trend of “decreasing-then increasing-then decreasing” with the increase of soil depth. …”

Trends over 10 years in children with severe acute malnutrition admitted at Moyo NRU. by Mphatso Nancy Chisala (20477275)

Distribution of study areas. by Jie Zhang (64655)

“…(main findings) The results show the following: (1) the primary term of government innovation preferences has a positive effect on the ecological resilience of resource-based cities, and the secondary term has a negative effect, with a decreasing marginal effect. …”

Descriptive statistics of variables. by Jie Zhang (64655)

“…(main findings) The results show the following: (1) the primary term of government innovation preferences has a positive effect on the ecological resilience of resource-based cities, and the secondary term has a negative effect, with a decreasing marginal effect. …”

Code. by Jie Zhang (64655)

“…(main findings) The results show the following: (1) the primary term of government innovation preferences has a positive effect on the ecological resilience of resource-based cities, and the secondary term has a negative effect, with a decreasing marginal effect. …”

Schematic of the conclusions. by Jie Zhang (64655)

“…(main findings) The results show the following: (1) the primary term of government innovation preferences has a positive effect on the ecological resilience of resource-based cities, and the secondary term has a negative effect, with a decreasing marginal effect. …”

Robustness test. by Jie Zhang (64655)

“…(main findings) The results show the following: (1) the primary term of government innovation preferences has a positive effect on the ecological resilience of resource-based cities, and the secondary term has a negative effect, with a decreasing marginal effect. …”