DataSheet1_Primary ovarian insufficiency consequence of autoimmune diseases: a bidirectional two-sample Mendelian randomization study.pdf by Yongming Du (807059)

“…</p>Results<p>The MR analyses revealed that genetically determined coeliac disease (CeD) (OR = 1.124, 95% CI 1.033-1.224, P = 0.007), vitiligo (OR = 1.092, 95% CI 1.003-1.188; P = 0.042), systemic lupus erythematosus (SLE) (OR = 1.122, 95% CI 1.030-1.223, P = 0.008), and selective immunoglobulin A deficiency (SIgAD) (OR = 0.866, 95% CI: 0.776-0.967, P = 0.011) exhibited significant causal relationships with POI. We also found suggestive evidence of positive effect of Addison’s disease (AD) towards POI (OR_5e-6 = 1.076, 95% CI 1.002-1.154, P = 0.043).…”

Data Sheet 1_Genome-wide development of SSR molecular markers for modern sugarcane cultivars.docx by Yi Xu (131145)

“…We identified SSR loci in the whole genome of XTT22, a modern sugarcane cultivar. …”

Multi-omics revealed GOT1/ALDH3A1 pathway attenuated head and neck squamous cell carcinoma and increased cisplatin sensitivity through ROS induced by mitochondrial dysfunction by Zhihui Liu (95891)

“…Given that mitochondria are the primary source of reactive oxygen species (ROS), we assessed cellular ROS and mitochondrial superoxide levels by flow cytometry and found a significant increase. …”

DataSheet3_Primary ovarian insufficiency consequence of autoimmune diseases: a bidirectional two-sample Mendelian randomization study.pdf by Yongming Du (807059)

“…</p>Results<p>The MR analyses revealed that genetically determined coeliac disease (CeD) (OR = 1.124, 95% CI 1.033-1.224, P = 0.007), vitiligo (OR = 1.092, 95% CI 1.003-1.188; P = 0.042), systemic lupus erythematosus (SLE) (OR = 1.122, 95% CI 1.030-1.223, P = 0.008), and selective immunoglobulin A deficiency (SIgAD) (OR = 0.866, 95% CI: 0.776-0.967, P = 0.011) exhibited significant causal relationships with POI. We also found suggestive evidence of positive effect of Addison’s disease (AD) towards POI (OR_5e-6 = 1.076, 95% CI 1.002-1.154, P = 0.043).…”

DataSheet5_Primary ovarian insufficiency consequence of autoimmune diseases: a bidirectional two-sample Mendelian randomization study.pdf by Yongming Du (807059)

“…</p>Results<p>The MR analyses revealed that genetically determined coeliac disease (CeD) (OR = 1.124, 95% CI 1.033-1.224, P = 0.007), vitiligo (OR = 1.092, 95% CI 1.003-1.188; P = 0.042), systemic lupus erythematosus (SLE) (OR = 1.122, 95% CI 1.030-1.223, P = 0.008), and selective immunoglobulin A deficiency (SIgAD) (OR = 0.866, 95% CI: 0.776-0.967, P = 0.011) exhibited significant causal relationships with POI. We also found suggestive evidence of positive effect of Addison’s disease (AD) towards POI (OR_5e-6 = 1.076, 95% CI 1.002-1.154, P = 0.043).…”

Presentation1_Pressure-tolerant survival mechanism of Schizophyllum commune 20R-7-F01 isolated from deep sediments 2 kilometers below the seafloor.pdf by Mengshi Zhao (20157978)

“…By assessing the cell viability, biomass, and cell wall thickness changes of strain 20-7-1 under different HHP conditions, we observed that, compared to 0.1 MPa, strain 20-7-1 exhibited slower growth rates and decreased cell viability at 15 MPa and 35 MPa, yet demonstrated significant pressure tolerance. …”

Data Sheet 1_PM2.5 exposure reprograms cell cycle dynamics in uterine immune cells at single-cell resolution.docx by Lin Zhang (8926)

“…</p>Results<p>PM2.5 exposure induced distinct alterations in immune cell composition and cell cycle distributions. Notably, we observed significant changes in immune cell populations, including reductions in macrophages (510 to 58 cells), NK cells (445 to 91 cells), and granulocytes (1597 to 1 cells). …”

DataSheet2_Primary ovarian insufficiency consequence of autoimmune diseases: a bidirectional two-sample Mendelian randomization study.pdf by Yongming Du (807059)

“…</p>Results<p>The MR analyses revealed that genetically determined coeliac disease (CeD) (OR = 1.124, 95% CI 1.033-1.224, P = 0.007), vitiligo (OR = 1.092, 95% CI 1.003-1.188; P = 0.042), systemic lupus erythematosus (SLE) (OR = 1.122, 95% CI 1.030-1.223, P = 0.008), and selective immunoglobulin A deficiency (SIgAD) (OR = 0.866, 95% CI: 0.776-0.967, P = 0.011) exhibited significant causal relationships with POI. We also found suggestive evidence of positive effect of Addison’s disease (AD) towards POI (OR_5e-6 = 1.076, 95% CI 1.002-1.154, P = 0.043).…”

DataSheet8_Primary ovarian insufficiency consequence of autoimmune diseases: a bidirectional two-sample Mendelian randomization study.zip by Yongming Du (807059)

“…</p>Results<p>The MR analyses revealed that genetically determined coeliac disease (CeD) (OR = 1.124, 95% CI 1.033-1.224, P = 0.007), vitiligo (OR = 1.092, 95% CI 1.003-1.188; P = 0.042), systemic lupus erythematosus (SLE) (OR = 1.122, 95% CI 1.030-1.223, P = 0.008), and selective immunoglobulin A deficiency (SIgAD) (OR = 0.866, 95% CI: 0.776-0.967, P = 0.011) exhibited significant causal relationships with POI. We also found suggestive evidence of positive effect of Addison’s disease (AD) towards POI (OR_5e-6 = 1.076, 95% CI 1.002-1.154, P = 0.043).…”

Table 1_Elucidating the causal relationship between 486 genetically predicted blood metabolites and the risk of gastric cancer: a comprehensive Mendelian randomization analysis.xls... by Lei Qian (292302)

“…</p>Results<p>The MVMR analysis revealed a significant association between genetically predicted elevated levels of tryptophan (odds ratio [OR] = 0.523, 95% confidence interval [CI] = 0.313–0.872, p = 0.013), nonadecanoate (19:0) (odds ratio [OR] = 0.460, 95% confidence interval [CI] = 0.225–0.943, p = 0.034), and erythritol (odds ratio [OR] = 0.672, 95% confidence interval [CI] = 0.468–0.930, p = 0.016) with a decreased risk of gastric cancer. …”

Table_1_Construction of a risk screening and visualization system for pulmonary nodule in physical examination population based on feature self-recognition machine learning model.X... by Fang Tian (360682)

“…</p>Results<p>Multivariable analysis identified older age, smoking or passive smoking, high psychological stress within the past year, occupational exposure (e.g., air pollution at the workplace), presence of chronic lung diseases, and elevated carcinoembryonic antigen levels as significant risk factors for pulmonary nodules. The feature self-recognition machine learning model further highlighted age, smoking or passive smoking, high psychological stress, occupational exposure, chronic lung diseases, family history of lung cancer, decreased albumin levels, and elevated carcinoembryonic antigen as key predictors for early pulmonary nodule risk, demonstrating superior performance.…”

Supplementary Material for: Association of Two Neonatal Encephalopathy Scores with Neurophysiology in Newborns with Suspected Hypoxic Ischemic Encephalopathy by figshare admin karger (2628495)

“…Study Design/Methods: We retrospectively analyzed associations between two NE scores, aEEG, and cEEG in 321 newborns in a 14-center collaborative NE Registry. …”

Data Sheet 1_A systematic review of the effects of nanoplastics on fish.pdf by Asok K. Dasmahapatra (2275549)

“…NAP exposure leads to significant adverse effects including increased oxidative stress, decreased locomotor and foraging activities, altered growth, immunity, lipid metabolism, and induced neurotoxicity. …”

India-Asia collisional processes: constraints from the Eocene magmatic rocks in the southern Tibetan Plateau by Li-Qiang Zhang (1312050)

“…The La/Yb, Sm/Yb, and Dy/Yb values are widely used for the quantitative inversion of crustal thickness. We found that the La/Yb, Sm/Yb, and Dy/Yb values of 70–40 Ma intermediate-acidic magmatic rocks in the southern Tibetan Plateau began to increase from ca. 58 Ma, reached a peak at ca. 52 Ma, and then slowly decreased, indicating that crustal thickening-thinning processes may have occurred during the Eocene and crustal thickening peaked at ca. 52 Ma. …”

Comparison of opioid use among long-term care residents in Ontario and Alberta, Canada: A multi-jurisdictional, repeated cross-sectional study by Colleen J. Maxwell (3818041)

“…In both provinces, there were significant decreases in higher risk opioid prescribing over time, including concurrent use with benzodiazepines, but also significant increases in the concurrent use with gabapentinoids and tramadol use (Alberta only).…”

Care quality. by Youssef Hbid (18803761)

“…<div><p>Background and aim</p><p>The COVID-19 pandemic imposed significant pressures on healthcare services such as stroke care. …”

Outcomes at discharge. by Youssef Hbid (18803761)

“…<div><p>Background and aim</p><p>The COVID-19 pandemic imposed significant pressures on healthcare services such as stroke care. …”

Patient characteristics. by Youssef Hbid (18803761)

“…<div><p>Background and aim</p><p>The COVID-19 pandemic imposed significant pressures on healthcare services such as stroke care. …”

Table2_The short-chain fatty acid receptors Gpr41/43 regulate bone mass by promoting adipogenic differentiation of mesenchymal stem cells.xlsx by Friederike Behler-Janbeck (3384488)

“…In addition, we isolated bone marrow derived mesenchymal stem cells from WT and Gpr41/43 dKO mice and differentiated them into osteoblasts in the absence or presence of acetate. …”

Table2_The short-chain fatty acid receptors Gpr41/43 regulate bone mass by promoting adipogenic differentiation of mesenchymal stem cells.xlsx by Friederike Behler-Janbeck (3384488)

“…In addition, we isolated bone marrow derived mesenchymal stem cells from WT and Gpr41/43 dKO mice and differentiated them into osteoblasts in the absence or presence of acetate. …”