Image1_Causal relationship between antihypertensive drugs and Hashimoto’s thyroiditis: a drug-target Mendelian randomization study.tif by Bing Cui (179696)

“…Moreover, genetically mimicking the use of loop diuretics (OR [95% CI]: 0.94 [0.91, 0.97]; p = 3.57×10^-5) and thiazide diuretics (0.98 [0.96, 0.99]; p = 3.83×10^-3) showed a significant association with a decreased risk of HT only in European population. …”

Table4_Causal relationship between antihypertensive drugs and Hashimoto’s thyroiditis: a drug-target Mendelian randomization study.xlsx by Bing Cui (179696)

“…Moreover, genetically mimicking the use of loop diuretics (OR [95% CI]: 0.94 [0.91, 0.97]; p = 3.57×10^-5) and thiazide diuretics (0.98 [0.96, 0.99]; p = 3.83×10^-3) showed a significant association with a decreased risk of HT only in European population. …”

Table5_Causal relationship between antihypertensive drugs and Hashimoto’s thyroiditis: a drug-target Mendelian randomization study.xlsx by Bing Cui (179696)

“…Moreover, genetically mimicking the use of loop diuretics (OR [95% CI]: 0.94 [0.91, 0.97]; p = 3.57×10^-5) and thiazide diuretics (0.98 [0.96, 0.99]; p = 3.83×10^-3) showed a significant association with a decreased risk of HT only in European population. …”

Data Sheet 3_Efficacy and safety of hydroxyurea therapy on patients with β-thalassemia: a systematic review and meta-analysis.pdf by Tianmin Huang (20561477)

“…HU, in transfusion-dependent β-thalassemia patients, was related to a significant decrease in transfusion requirements [a pooled RR of 0.37 and a pooled good RR of 0.65 (95% CI, 0.53–0.76)]; in transfusion-independent β-thalassemia patients, it was correlated to an excellent raise in Hb levels [a pooled RR of 0.20 (95% CI, 0.08–0.35) and a pooled good RR of 0.53 (95% CI, 0.41–0.65)]. …”

Image2_Causal relationship between antihypertensive drugs and Hashimoto’s thyroiditis: a drug-target Mendelian randomization study.tif by Bing Cui (179696)

“…Moreover, genetically mimicking the use of loop diuretics (OR [95% CI]: 0.94 [0.91, 0.97]; p = 3.57×10^-5) and thiazide diuretics (0.98 [0.96, 0.99]; p = 3.83×10^-3) showed a significant association with a decreased risk of HT only in European population. …”

Data Sheet 2_Efficacy and safety of hydroxyurea therapy on patients with β-thalassemia: a systematic review and meta-analysis.pdf by Tianmin Huang (20561477)

“…HU, in transfusion-dependent β-thalassemia patients, was related to a significant decrease in transfusion requirements [a pooled RR of 0.37 and a pooled good RR of 0.65 (95% CI, 0.53–0.76)]; in transfusion-independent β-thalassemia patients, it was correlated to an excellent raise in Hb levels [a pooled RR of 0.20 (95% CI, 0.08–0.35) and a pooled good RR of 0.53 (95% CI, 0.41–0.65)]. …”

Table1_Causal relationship between antihypertensive drugs and Hashimoto’s thyroiditis: a drug-target Mendelian randomization study.xlsx by Bing Cui (179696)

“…Moreover, genetically mimicking the use of loop diuretics (OR [95% CI]: 0.94 [0.91, 0.97]; p = 3.57×10^-5) and thiazide diuretics (0.98 [0.96, 0.99]; p = 3.83×10^-3) showed a significant association with a decreased risk of HT only in European population. …”

Table3_Causal relationship between antihypertensive drugs and Hashimoto’s thyroiditis: a drug-target Mendelian randomization study.xlsx by Bing Cui (179696)

“…Moreover, genetically mimicking the use of loop diuretics (OR [95% CI]: 0.94 [0.91, 0.97]; p = 3.57×10^-5) and thiazide diuretics (0.98 [0.96, 0.99]; p = 3.83×10^-3) showed a significant association with a decreased risk of HT only in European population. …”

Infection of CD 34 by Ancy Joseph (5634794)

“…<p><b>+</b><b> humanized mice resulted in decrease in pathogenicity in CTCF Infected mice.</b> A. …”

Supplementary Material for: A Randomized Controlled Crossover Trial to Determine the Effects of Three Nostril Regulated Breathing Practices on Attention and Mood by figshare admin karger (2628495)

“…A significant main effect of states was observed followed by significant post-hoc pair wise comparison in right NDR for (i) pleasant mood after SAV, CAV, AV and QS, (ii) positive mood after SAV and AV, and (iii) global vigor after SAV, CAV, AV and QS, and (iv) a decrease in negative mood after CAV and AV. …”

Association of lactate-albumin ratio with native liver survival in paediatric acute liver failure: a 10-year retrospective study by Zhen Zhang (86004)

“…</p> <p>Among 77 patients, 46.8% (36 cases) had SNL, with 14.3% (11 cases) requiring transplantation. A significant decrease in SNL was associated with higher LAR (<i>p</i> = 0.005), with a 4% decline in SNL for each 1% increase in LAR. …”

Supplementary Material for: The impact of laparoscopic cystectomy for ovarian endometrioma on anti-Mullerian hormone levels: a systematic review and meta-analysis by figshare admin karger (2628495)

“…Primary outcomes showed a statistically significant (P < 0.001) decrease in anti-Müllerian hormone in the postoperative short-term period [-1.39 ng/mL, 95% CI, -2.01- (-0.76)], medium term period [-1.13 ng/mL (95% CI, -1.4- (-0.87)], and long term [-2.12 ng/mL (95% CI, -2.61- (-1.63)]. …”

Table 1_Efficacy of thymosin α1 for sepsis: a systematic review and meta-analysis of randomized controlled trials.docx by Bin Gu (223694)

“…The comprehensive meta-analysis demonstrated a significant reduction in 28-day mortality associated with Tα1 administration (OR 0.73, 95%CI: 0.59-0.90, P = 0.003). …”

Figure 5 from Clinical Validation of a Cell-Free DNA Fragmentome Assay for Augmentation of Lung Cancer Early Detection by Peter J. Mazzone (20018668)

“…Population-level modeling demonstrates significant health benefits when a blood-based test is available as an alternative for lung cancer screening.…”

Data Sheet 1_Gut microbiota interacting with vitamin D but not anandamide might contribute to the pathogenesis of preeclampsia: a preliminary study.pdf by Xiao-Qiang Han (596982)

“…Compared with the LP group, the relative abundances of Prevotella, Erysipelotrichaceae_UCG-003, and Dorea were increased dramatically in the PE group, whereas the relative abundances of Subdoligranulum, Parabacteroides, Bacteroides were significantly decreased in the PE group. Furthermore, women with PE had a substantially lower plasma level of AEA and a marked decrease in serum VitD compared to normal late-pregnant women. …”

Supplementary file 1_Dynamic reconfiguration and transition of whole-brain networks in patients with MELAS revealed by a hidden Markov model.docx by Qingyun Yu (18837625)

“…The lifetimes of HMM states showed a similar decrease as fractional occupancies. The switching frequency of HMM states was significantly increased in MELAS (p < 0.001). …”

Original images for explaining Fig 4. by Reiri Takeuchi (20460788)

“…Treatment with cyclosporine A markedly increased cell proliferation, inhibited G₁ cell cycle arrest, significantly increased <i>CDC25A</i> and <i>CYCLIN E1</i> mRNA expression levels, significantly decreased <i>P21</i>, <i>SMAD3</i> and <i>SMAD4</i> mRNA expression levels, significantly upregulated the protein expression levels of CDC25A, CYCLIN E1, pCDK2 and pRB1 and significantly downregulated the protein expression levels of P21, SMAD3 and SMAD4. …”

Numbers of nuclei and centrioles per cell. by Yang-In Yim (324355)

“…Note that the values in (D) for HSET KD and combined KD of Myo10 KD and HSET, while significantly different from the control, represent decreases in centriole number, not increases (these decreases may be due to the anti-proliferative effects of HSET KD). …”

SLC response kinematics at 6 dpf. by Morgan Barnes (7876373)

“…<p>(A-B) C1 is the first C-bend performed. The angle and duration of the C1 bend is significantly decreased in 24 + fish (p < 0.0001 and p < 0.05) compared to the 24- fish and the C1 angle is decreased in 72 + fish (p < 0.05). …”

Functional enrichment analysis. by Andrea Salinas (4963834)

“…Finally, the extract significantly decreased concanavalin A (ConA)-induced T cell proliferation. …”