Cardiovascular safety of Janus kinase inhibitors in inflammatory bowel disease: a systematic review and network meta-analysis by Huibin Yang (10486204)

“…</p> <p>Although a trend of increased cardiovascular risks was found considering dose, no significantly increased cardiovascular risk was associated with JAKinibs in IBD patients, and Deucravacitinib significantly decreased the risks of VTE and CVE.…”

Image2_Combined administration of catalpol, puerarin, gastrodin, and borneol modulates the Tlr4/Myd88/NF-κB signaling pathway and alleviates microglia inflammation in Alzheimer’s d... by Huijing Ren (19986303)

“…Interference with this pathway significantly influenced the therapeutic effects of CPGB in the 3D-NVU model. …”

DataSheet1_Combined administration of catalpol, puerarin, gastrodin, and borneol modulates the Tlr4/Myd88/NF-κB signaling pathway and alleviates microglia inflammation in Alzheimer... by Huijing Ren (19986303)

“…Interference with this pathway significantly influenced the therapeutic effects of CPGB in the 3D-NVU model. …”

Image1_Combined administration of catalpol, puerarin, gastrodin, and borneol modulates the Tlr4/Myd88/NF-κB signaling pathway and alleviates microglia inflammation in Alzheimer’s d... by Huijing Ren (19986303)

“…Interference with this pathway significantly influenced the therapeutic effects of CPGB in the 3D-NVU model. …”

Data Sheet 1_Influence of water temperature on feed intake, appetite control, and energy allocation in Atlantic salmon (Salmo salar) post-smolt.pdf by F. Lai (17234491)

“…Plasma ghrelin (Ghrl) levels decreased significantly at elevated temperature. Temperature negatively affected the ghrl1 expression in the stomach, and the expression dynamics of the orexigenic neuropeptide npya and anorexigenic pomca paralogues in the hypothalamus, which were lower at 15°C. …”

<b>Impact of Magnitude and Duration of Soil Warming on Bacterial Communities and Nitrogen Cycling in the Rhizosphere and Bulk Soil of Subarctic Grasslands</b> by Arun Kumar Devarajan (21358373)

“…The results revealed that bacterial abundances showed significant warming thresholds at lower temperature increases in the rhizospheres (+0.83℃ in GN, +1.34℃ in GO) compared to bulk soils (+1.42℃ in GN; no threshold detected in GO), with abundances declining below these thresholds, indicating greater warming sensitivity of rhizosphere communities. …”

Data Sheet 1_Probiotic administration correlated with reduced diarrheal incidence and improved gut microbiota diversity in young goats.pdf by Mohamed Osman Abdalrahem Essa (21562583)

“…</p>Results<p>Healthy groups exhibited significantly greater species richness and diversity compared to the diarrheal group (p < 0.01). …”

Tanshinone I as a novel therapeutic agent targeting von Willebrand factor-binding protein to mitigate <i>Staphylococcus aureus</i> pathogenicity by Shiyu Zhou (457967)

“…Additionally, tanshinone I was tested in greater wax moth larvae and showed similar protective effects. …”

Data Sheet 1_Effect of cultivation feed diet using local food processing by-products on the growth and flavor factor in the Malabar grouper Epinephelus malabaricus.docx by Makoto Takahashi (386772)

“…Sensory analysis indicated comparable overall taste quality between the two groups. FW-D fillets had greater chewiness and reduced fishy odor, whereas CO-D fillets were richer in fatty taste.…”

Data Sheet 1_Susceptibility to and severity of tuberculosis infection in mice depends upon MHC-II-determined level of activation-inhibition balance in CD4 T-cells.pdf by Nadezhda Logunova (831700)

“…<p>Previously we have shown that H2-congenic recombinant mice of the B6.I-9.3 (H2-Ab1^j) strain are significantly more susceptible to tuberculosis (TB) infection compared to their C57BL/6 (B6, H2-A^b) ancestors. …”

DataSheet1_Global burden of chronic kidney disease in adolescents and young adults, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019.docx by Ping Sun (59933)

“…However, the global age-specific death rate significantly decreased from 2.96 (2.76, 3.15) to 2.86 (2.61, 3.11), and the age-specific DALY rate remained stable. …”

Data Sheet 2_Early boosting of p38 MAPK signaling pathway by lycorine hydrochloride potently inhibits PRRSV proliferation in primary and established cells.pdf by Lizhan Su (19936980)

“…Mechanistically, LH treatment induced a rapid up-regulation of p38 MAPK signaling pathway in both infected and uninfected cells, which enhanced the expressions of NLRP3 and Caspase-1 proteins, thereby promoting the conversion of pro-IL-1β to IL-1β, which led to decreased PRRSV replication. In summary, this study reveals that early boosting of p38 MAPK signaling pathway induced by LH treatment significantly suppresses PRRSV propagation, and LH has the potential to be used as a novel antiviral agent against PRRSV infections.…”

Data Sheet 1_Comparative hepatoprotective effects of AMK and PAMK via Nrf2 signaling in broiler breeders.pdf by Baili Lu (21192662)

“…Histopathological analysis revealed better-preserved liver structure and less inflammatory infiltration in PAMK-fed hens. …”

Scarless excision of an insertion sequence in the OmpK36 promoter restores meropenem susceptibility in a non-carbapenemase-producing <i>Klebsiella pneumoniae</i> by Yingying Du (5877701)

“…<p>Carbapenem-resistant <i>Klebsiella pneumoniae</i> (CRKP) poses a significant global health challenge due to its limited treatment options and high mortality rates. …”

<b><i>Escherichia coli α-hemolysin induces red blood cell retention in a microfluidic spleen-like device</i></b> by Nicolas Saffioti (9965939)

“…While its lytic effects are well characterized, the non-lytic alterations on RBCs, such as increased permeability to Ca²⁺, osmotic imbalance, and morphological alterations, remain less understood and may be critical in UPEC pathogenesis. …”

Data Sheet 1_Early boosting of p38 MAPK signaling pathway by lycorine hydrochloride potently inhibits PRRSV proliferation in primary and established cells.pdf by Lizhan Su (19936980)

“…Mechanistically, LH treatment induced a rapid up-regulation of p38 MAPK signaling pathway in both infected and uninfected cells, which enhanced the expressions of NLRP3 and Caspase-1 proteins, thereby promoting the conversion of pro-IL-1β to IL-1β, which led to decreased PRRSV replication. In summary, this study reveals that early boosting of p38 MAPK signaling pathway induced by LH treatment significantly suppresses PRRSV propagation, and LH has the potential to be used as a novel antiviral agent against PRRSV infections.…”

Table 1_Effects of salinity stress on morphological structure, physiology, and mRNA expression in different wheat (Triticum aestivum L.) cultivars.doc by Xiaohui Sun (520181)

“…Electron microscopic studies revealed that salinity stress caused significantly more root hairs and less effect on normal chloroplast structure in QM6 than these in CS. …”

feature parameters by CHIN-CHENG CHU (20718575)

“…<p dir="ltr">We evaluated seven eye‐movement features before and after fatigue using paired t‐tests on mean ± SD values. …”

Data Sheet 1_Bacteriocin KvarM versus conventional antibiotics: comparative effectiveness in treating Klebsiella pneumoniae infections in murine intestinal models.pdf by Indre Karaliute (20906606)

“…Furthermore, microbiome analysis of the gut microbiota revealed that KvarM therapy showed no significant changes in microbial composition compared with commensal microbiota composition, whereas administration of ciprofloxacin led to a significant decrease in microbial diversity.…”

Data Sheet 1_Effect of sheep placenta extract on D-galactose-induced aging mouse.docx by Shan He (121220)

“…</p>Results<p>In the serum of aging mice treated with SPE, the levels of antioxidant function such as superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) were notably higher compared to those in the blank group, whereas malondialdehyde (MDA) levels decreased. We revealed that SPE alleviated the changes in gut microbiota caused by aging in mice, with a significant decrease in the Firmicutes/Bacteroidetes (F/B) ratio in the gut. …”