Image 1_Multi-omics analysis reveals neutrophil heterogeneity and key molecular drivers in sepsis-associated acute kidney injury.jpg by Tianle Cheng (20788417)

“…This study employed a multi-omics approach, integrating single-cell and bulk RNA sequencing from 21 sepsis samples and Escherichia coli-induced sepsis datasets, alongside bioinformatics, machine learning, and experimental validation in a rat model and human peripheral blood. We identified four neutrophil subtypes—pro-inflammatory, anti-inflammatory, mature, and immature—revealing a significant increase in pro-inflammatory neutrophils in sepsis (40.53% versus 4.19% in controls) and a decrease in anti-inflammatory neutrophils (18.43% versus 27.04%). …”

Image 2_Multi-omics analysis reveals neutrophil heterogeneity and key molecular drivers in sepsis-associated acute kidney injury.jpg by Tianle Cheng (20788417)

“…This study employed a multi-omics approach, integrating single-cell and bulk RNA sequencing from 21 sepsis samples and Escherichia coli-induced sepsis datasets, alongside bioinformatics, machine learning, and experimental validation in a rat model and human peripheral blood. We identified four neutrophil subtypes—pro-inflammatory, anti-inflammatory, mature, and immature—revealing a significant increase in pro-inflammatory neutrophils in sepsis (40.53% versus 4.19% in controls) and a decrease in anti-inflammatory neutrophils (18.43% versus 27.04%). …”

Penguin ease of transport for real vs. fully-compensated travel vectors relative to the ground during the return journey with respect to depth use and prey acquisition. by Richard M. Gunner (12652026)

“…Dive depths decrease to less than 10 m when <i>ca</i>. Eighty percent of the journey is complete (marked by the dashed grey vertical line). …”

Data Sheet 1_The role of statins in dementia or Alzheimer’s disease incidence: a systematic review and meta-analysis of cohort studies.docx by Ye Du (4067569)

“…In sensitivity analyses, diagnostic criteria for dementia/AD significantly affected the combined risk estimates. In subgroup analyses, compared to studies enrolling participants with a mean/median age over 70 years, those younger than 70 years exhibited greater efficacy of statins in preventing dementia (HR: 0.67, 95% CI: 0.56–0.81 vs HR: 0.86, 95% CI: 0.78–0.95; P = 0.02) and AD (HR: 0.47, 95% CI: 0.44–0.50 vs. …”

Table 1_Functional characterization of endocytic signals in the SynDIG/PRRT family members SynDIG1 and SynDIG4 in heterologous cells and neurons.xlsx by David J. Speca (20601326)

“…Loss of SynDIG4, and the subsequent decrease in extra-synaptic GluA1, has been found to significantly impact synaptic plasticity in the hippocampus. …”

Data Sheet 1_Determining the influence of tree age on tea quality-related metabolites in Camellia tachangensis var. remotiserrata by integrating metabolomic and transcriptomic anal... by Zhuorong Shi (22589729)

“…These metabolic changes align with flavor profiles of tea harvested from different tree ages: infusions from older trees are significantly less bitter and astringent and present apparent sweet and umami characteristics. …”

Table 1_Evaluation of clopidogrel responsiveness using the Platelet Function Analyzer-200 (PFA-200) in dogs.docx by Joon-Ho Shin (2161726)

“…Among the assessed parameters, only D-dimer levels showed a significant decrease in the clopidogrel-responder group (p < 0.05), suggesting its potential utility in evaluating responsiveness. …”

Table 2_Global burden of lung cancer in adolescents and adults aged 15–45: analysis of the global burden of disease study (1990–2021).xlsx by Ziqi Han (12840074)

“…</p>Results<p>Our findings reveal that while the number of lung cancer cases aged 15–45 increased by 22.1%, the age-standardized prevalence decreased by 23.9%; age-standardized mortality and DALYs declined significantly over the past three decades. …”

Table 3_Global burden of lung cancer in adolescents and adults aged 15–45: analysis of the global burden of disease study (1990–2021).xlsx by Ziqi Han (12840074)

“…</p>Results<p>Our findings reveal that while the number of lung cancer cases aged 15–45 increased by 22.1%, the age-standardized prevalence decreased by 23.9%; age-standardized mortality and DALYs declined significantly over the past three decades. …”

Table 4_Global burden of lung cancer in adolescents and adults aged 15–45: analysis of the global burden of disease study (1990–2021).xlsx by Ziqi Han (12840074)

“…</p>Results<p>Our findings reveal that while the number of lung cancer cases aged 15–45 increased by 22.1%, the age-standardized prevalence decreased by 23.9%; age-standardized mortality and DALYs declined significantly over the past three decades. …”

Table 1_Global burden of lung cancer in adolescents and adults aged 15–45: analysis of the global burden of disease study (1990–2021).xlsx by Ziqi Han (12840074)

“…</p>Results<p>Our findings reveal that while the number of lung cancer cases aged 15–45 increased by 22.1%, the age-standardized prevalence decreased by 23.9%; age-standardized mortality and DALYs declined significantly over the past three decades. …”

Table 1_Evaluation of the cardiorespiratory and antinociceptive effects of the total intravenous anesthesia technique with xylazine-butorphanol-propofol compared to isoflurane in c... by Shogo Sato (16544880)

“…HR decreased significantly from baseline in both groups. …”

Icaritin and lenvatinib treatment for unresectable localized progressive pancreatic cancer: a report of six cases by Xiaolong Liu (265696)

“…Cases 4 and 5 showed limited relief following a slight decrease in tumor size. In cases 2 and 6, no significant progression of the lesion was observed. …”

Supplementary Material for: The Association of Proteinuria Target Achievement Timing and Stability with Adverse Kidney Outcomes Among Patients with IgA Nephropathy: A Cohort Study by figshare admin karger (2628495)

“…We analyzed the association between those three metrics and the composite kidney outcome, which was defined as the first occurrence of either end-stage kidney disease (ESKD or a >50% decrease in eGFR from baseline. …”

Data Sheet 1_Case Report: Micronized purified flavonoid fraction [Daflon]-induced bradycardia.pdf by Jhennyfer Aline Lima Rodrigues (10278251)

“…During this period, there was a decrease in vein inflammation and varicosity, as shown by magnetic resonance imaging.…”

DataSheet1_Cross-National Trends in Early Sexual Initiation Among 15-Year-Old Adolescents, 2002–2022.xlsx by András Költő (10831323)

“…Parental support (and its interaction with time) also had a significant but small protective role.</p>Conclusion<p>Despite a small decrease over time, still 4% of participants reported early sexual initiation in 2022. …”

Table 2_The impact of long-term trends in continuity of care on the medical expenses of hypertensive patients: based on group-based trajectory model.xlsx by Yanqiu Du (6817550)

“…Patients in the high-level maintenance group incurred the lowest annual medical expenses (mean range: ¥3,786–¥5,088), while the low-level maintenance group exhibited the highest (mean range: ¥6,450–¥10,321). …”

Table 1_The impact of long-term trends in continuity of care on the medical expenses of hypertensive patients: based on group-based trajectory model.docx by Yanqiu Du (6817550)

“…Patients in the high-level maintenance group incurred the lowest annual medical expenses (mean range: ¥3,786–¥5,088), while the low-level maintenance group exhibited the highest (mean range: ¥6,450–¥10,321). …”

Table 3_The impact of long-term trends in continuity of care on the medical expenses of hypertensive patients: based on group-based trajectory model.xlsx by Yanqiu Du (6817550)

“…Patients in the high-level maintenance group incurred the lowest annual medical expenses (mean range: ¥3,786–¥5,088), while the low-level maintenance group exhibited the highest (mean range: ¥6,450–¥10,321). …”

Supplementary Material for: Efficacy of team‑based collaborative care for distressed patients in secondary prevention of chronic coronary heart disease: Results from the multicente... by figshare admin karger (2628495)

“…Further, TeamCare led to a significantly greater decrease in depression (d=-0.329), anxiety (d=-0.300), perceived stress (d=-0.233), and medical risk score (d=-0.235). …”