Image 8_Global burden of varicella and herpes zoster across 204 countries, 1990–2021: a temporal trend analysis in the era of the COVID-19 pandemic and projections to 2036.tiff by Zilun Wu (18696883)

“…Joinpoint regression analysis identified significant shifts in temporal trends, treating 2019 as a key inflection point to observe the pandemic’s impact. …”

Image 6_Global burden of varicella and herpes zoster across 204 countries, 1990–2021: a temporal trend analysis in the era of the COVID-19 pandemic and projections to 2036.tiff by Zilun Wu (18696883)

“…Joinpoint regression analysis identified significant shifts in temporal trends, treating 2019 as a key inflection point to observe the pandemic’s impact. …”

Image 1_Global burden of varicella and herpes zoster across 204 countries, 1990–2021: a temporal trend analysis in the era of the COVID-19 pandemic and projections to 2036.tiff by Zilun Wu (18696883)

“…Joinpoint regression analysis identified significant shifts in temporal trends, treating 2019 as a key inflection point to observe the pandemic’s impact. …”

Image 3_Global burden of varicella and herpes zoster across 204 countries, 1990–2021: a temporal trend analysis in the era of the COVID-19 pandemic and projections to 2036.tiff by Zilun Wu (18696883)

“…Joinpoint regression analysis identified significant shifts in temporal trends, treating 2019 as a key inflection point to observe the pandemic’s impact. …”

Data Sheet 1_Efficacy and safety of PCSK9 inhibitors, potent statins, and their combinations for reducing low-density lipoprotein cholesterol in hyperlipidemia patients: a systemat... by Yuhua Jiang (10300159)

“…Meanwhile, compared with placebo, evolocumab (MD −1.89, 95% CI −2.27 to −1.50), alirocumab (MD −1.83, 95% CI −2.09 to −1.57), rosuvastatin (MD −1.93, 95% CI −2.30 to −1.56), inclisiran (MD −1.68, 95% CI −2.10 to −1.27), and atorvastatin (MD −1.68, 95% CI −2.04 to −1.31) could also play a role in the treatment of LDL-C reduction. Moreover, the incidence of adverse events (AEs) was similar to that observed in the control group, which included both placebo and potent statin groups, with no significant differences identified in our study (P > 0.05).…”

Table 1_Characterizing HLA-A2-restricted CD8+ T-cell epitopes and immune responses to Omicron variants in SARS-CoV-2-inactivated vaccine recipients.doc by Chanchan Xiao (9522614)

“…</p>Methods<p>We conducted a comprehensive analysis of CD8 T-cell responses to SARS-CoV-2 inactivated vaccines, focusing on HLA-A2-restricted epitopes derived from the Omicron variant. …”

Image 2_Characterizing HLA-A2-restricted CD8+ T-cell epitopes and immune responses to Omicron variants in SARS-CoV-2-inactivated vaccine recipients.tif by Chanchan Xiao (9522614)

“…</p>Methods<p>We conducted a comprehensive analysis of CD8 T-cell responses to SARS-CoV-2 inactivated vaccines, focusing on HLA-A2-restricted epitopes derived from the Omicron variant. …”

Image 1_Characterizing HLA-A2-restricted CD8+ T-cell epitopes and immune responses to Omicron variants in SARS-CoV-2-inactivated vaccine recipients.tif by Chanchan Xiao (9522614)

“…</p>Methods<p>We conducted a comprehensive analysis of CD8 T-cell responses to SARS-CoV-2 inactivated vaccines, focusing on HLA-A2-restricted epitopes derived from the Omicron variant. …”

Table1_CHF6297: a novel potent and selective p38 MAPK inhibitor with robust anti-inflammatory activity and suitable for inhaled pulmonary administration as dry powder.DOCX by Cataldo Martucci (3117069)

“…In mice exposed to tobacco smoke (TS), CHF6297, administered intranasally (i.n.) for 4 days at 0.03 or 0.3 mg/kg, dose-dependently inhibited the corticosteroid-resistant TS-induced neutrophil influx in the BALF. In a murine house dust mite (HDM) model of asthma exacerbated by influenza virus A (IAV) (H3N3), CHF6297 (0.1 mg/kg, i.n.) significantly decreased airway neutrophilia compared to vehicle-treated IAV/HDM-challenged mice. …”

Table_1_Association between serum iron levels and atherosclerotic cardiovascular diseases among American older adults: a cross-sectional study based on the National Health and Nutr... by Xiaochen Yu (3796927)

“…For serum iron levels below 131 μg/dL, each 10 μg/dL increase was associated with a 4% decrease in the odds of ASCVD (OR = 0.96; 95% CI, 0.93–0.98, p < 0.001). …”

Table1_Trends of antiseizure medication utilization among pregnant people in four Canadian provinces from 1998 to 2023; a study from the Canadian mother-child cohort active surveil... by Payam Peymani (12433284)

“…ASM utilization by drug class showcased significant shifts, with second-generation ASMs experiencing a notable rise. …”

Immunogenicity persistence after four intramuscular triple-dose or standard-dose hepatitis B vaccine in patients receiving methadone maintenance treatment: A 1-year follow-up study... by Xinyuan Mo (15468948)

“…All three hepatitis B vaccine regimens demonstrated comparable declines in anti-HBs levels, with a rapid decrease observed within 1-year of follow-up.…”

Data Sheet 1_Induction immunochemotherapy followed by definitive chemoradiotherapy and consolidation immunotherapy for unresectable stage III non-small cell lung cancer: a multi-in... by Zhixue Fu (7540256)

“…The I-CRT-I group showed a significant improvement in OS compared with the CRT-I group (p=0.004). …”

Supplementary file 1_Full-dose versus reduced-dose comparison of direct oral anticoagulants for extended treatment of venous thromboembolism: a systematic review and meta-analysis... by Renshu Zhang (22775495)

“…</p>Conclusion<p>Reduced-dose DOACs were associated with a significant decrease in the risk of major bleeding/CRNMB compared with full-dose DOACs, but were not associated with a significant increase in the risk of recurrent VTE. …”

Data Sheet 1_Assessment of heat-killed E. coli expressing Chikungunya virus E2 protein as a candidate vaccine for dual protection against Chikungunya virus and E. coli.docx by Surajit Patra (18400578)

“…The CHIKV neutralization assay results showed a two-fold decrease in CHIKV TCID50 value after 12 hours and a three-fold reduction after 120 hours. …”

Treatment consequence and adverse events of cyclin-dependent kinase 4/6 inhibitors on patients with hormone receptor-positive, HER2-negative metastatic breast cancer: a systematic... by Hsiang-Ying Wu (22212274)

“…</p> <p>Eleven clinical trials published between 2015 and 2022 were included in our meta-analysis, with a total of 5572 eligible patients. This meta-analysis found that HR(+)/HER2(−) metastatic breast cancer treated with CDK4/6 inhibitors plus endocrine therapy can significantly improve progression-free survival(PFS) (HR: 0.55; <i>p</i> < 0.001), overall survival (OS) (HR: 0.79; <i>p</i> < 0.001), objective response rate (RR = 1.50; <i>p</i> < 0.001), clinical benefit rate (RR = 1.18; <i>p</i> < 0.001) and decrease progressive disease rate (RR = 0.49; <i>p</i> < 0.001). …”

Supplementary Material for: A retrospective analysis of the diagnosis of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) at The Ottawa Hospital Cancer Centre (TOHCC) over t... by Alrehaili M. (19737907)

“…Our objective was to assess trends in GEP-NETs diagnosis (June 2010 to June 2021) at TOHCC and to explore whether early COVID-19 pandemic data impacted these trends. Methods: This was a single center retrospective chart review of data collected from June 2010 to June 2021. …”

Table 1_Biomechanical mechanisms of multidirectional dynamic compensatory muscle fatigue induced by abnormal cervical curvature: a cross-sectional case-control study based on surfa... by Rui Yang (293531)

“…During dynamic activities, muscle fatigue was exacerbated in the abnormal curvature group: during extension, the left UT showed significantly decreased MPF (p < 0.01) and MF (p < 0.05); during flexion, the left SCM exhibited significantly increased MPFs (p < 0.05) and MFs (p < 0.01). …”

Table 1_Evaluation of the clinical application of information-motivation-behavior model care combined with labetalol pharmacotherapy for patients with hypertensive disorders of pre... by Linling Sun (22465585)

“…In addition, the intervention group had a longer gestational week of delivery (p = 0.04), less chance of vaginal delivery to caesarean section (p = 0.048), and a trend towards a decrease in the incidence of adverse pregnancy outcomes such as preterm labor and adverse effects such as nausea, albeit not statistically significant (p > 0.05).…”

Table 3_Association between platelet-to-red cell distribution width ratio and all-cause mortality in critically ill patients with non-traumatic cerebral hemorrhage: a retrospective... by Rongrong Lu (322302)

“…Following adjustment for confounding factors, patients with elevated PRR exhibited a significantly decreased risk of in-hospital death (HR, 0.98; 95% CI, 0.96–0.99; p = 0.006) and ICU death (HR, 0.98; 95% CI, 0.96–0.99; p = 0.027). …”