Proteomics and Metabolomics Analyses Reveal a Dynamic Landscape of Coal Workers’ Pneumoconiosis: An Insight into Disease Progression by Yangyang Wei (436909)

“…Integrated analysis found that ABC transporters are a shared pathway among the three groups, and ABCD2 is involved in the ABC transporter pathway. …”

Proteomics and Metabolomics Analyses Reveal a Dynamic Landscape of Coal Workers’ Pneumoconiosis: An Insight into Disease Progression by Yangyang Wei (436909)

“…Integrated analysis found that ABC transporters are a shared pathway among the three groups, and ABCD2 is involved in the ABC transporter pathway. …”

Proteomics and Metabolomics Analyses Reveal a Dynamic Landscape of Coal Workers’ Pneumoconiosis: An Insight into Disease Progression by Yangyang Wei (436909)

“…Integrated analysis found that ABC transporters are a shared pathway among the three groups, and ABCD2 is involved in the ABC transporter pathway. …”

Proteomics and Metabolomics Analyses Reveal a Dynamic Landscape of Coal Workers’ Pneumoconiosis: An Insight into Disease Progression by Yangyang Wei (436909)

“…Integrated analysis found that ABC transporters are a shared pathway among the three groups, and ABCD2 is involved in the ABC transporter pathway. …”

PIK3C3 is not involved in the formation of PtdIns(3)P at the inner membrane of protrusions. by Steven J. Rolland (21376879)

PIK3C3 is required for efficient cell-to-cell spread <i>in vivo.</i> by Steven J. Rolland (21376879)

Phenotype analysis of PbPP6-GFP parasites. by Yonghui Feng (12227596)

Sequence composition analysis identifies distinct A + U and C + G base frequencies within subregions of mRNA transcripts – with effects on protein coding potential. by Benjamin S. Pickard (21276556)

Frequency trajectories of iSNVs that fluctuated (Top) and their positions on the genome (Bottom) (patients A-I). by Lele Zhao (532080)

Addressing Imbalanced Classification Problems in Drug Discovery and Development Using Random Forest, Support Vector Machine, AutoGluon-Tabular, and H2O AutoML by Ayush Garg (21090944)

“…The important findings of our studies are as follows: (i) there is no effect of threshold optimization on ranking metrics such as AUC and AUPR, but AUC and AUPR get affected by class-weighting and SMOTTomek; (ii) for ML methods RF and SVM, significant percentage improvement up to 375, 33.33, and 450 over all the data sets can be achieved, respectively, for F1 score, MCC, and balanced accuracy, which are suitable for performance evaluation of imbalanced data sets; (iii) for AutoML libraries AutoGluon-Tabular and H2O AutoML, significant percentage improvement up to 383.33, 37.25, and 533.33 over all the data sets can be achieved, respectively, for F1 score, MCC, and balanced accuracy; (iv) the general pattern of percentage improvement in balanced accuracy is that the percentage improvement increases when the class ratio is systematically decreased from 0.5 to 0.1; in the case of F1 score and MCC, maximum improvement is achieved at the class ratio of 0.3; (v) for both ML and AutoML with balancing, it is observed that any individual class-balancing technique does not outperform all other methods on a significantly higher number of data sets based on F1 score; (vi) the three external balancing techniques combined outperformed the internal balancing methods of the ML and AutoML; (vii) AutoML tools perform as good as the ML models and in some cases perform even better for handling imbalanced classification when applied with imbalance handling techniques. …”

Serum metabolomic response to aging. by Gwangho Yoon (5771678)

“…<b>(B)</b> Metabolites that decreased with aging. Statistical significance is indicated in the heatmap with asterisks. …”

Relative expression of hub genes. by Ziyang Liu (242055)

Various stereological parameters characterizing lung parenchyma and AEII before, during and after alveolarization as well as in adults. by Julia Hüttmann (22656283)

“…PLoS One. 2024 Mar 14;19(3):e029. b) The total number of alveolar epithelial cells type II (N(AEII, lung)) shows a significant increase after the end of bulk alveolarization and in adults compared to 3 days old rats. c) During alveolarization the number of AEII per mm² alveolar surface (N(AEII, lung)/S(alveoli, lung)) decreases continuously reaching the significant lowest values in adults. d) The number of AEII related to lung volume decreases continuously during alveolarization. …”

The atrium and ventricle exhibit different tissue dynamics during morphogenesis. by Juliana Sánchez-Posada (20636677)

“…Total endocardial volume decreases after 58 hpf (D), driven by a reduction in endocardial tissue in both the atrium and ventricle (E); 34–36 hpf: <i>n</i> = 9; 48–50 hpf: <i>n</i> = 10; 58–60 hpf: <i>n</i> = 8; 72–74 hpf: <i>n</i> = 10. …”

Data file without outliers. by Helena Wallin (6103205)

“…At follow-up, the increase in KYN and KYN/TRP was related to a decrease in ExCap in CKD 2–3. After adjusting for GFR, increase in KYN/TRP remained an independent significant predictor of a decline in ExCap in CKD 2–3.…”

Effects of Ni²⁺ on mitochondrial (A), glycolytic (B), and total (C) ATP production rates in BMDM. by Jesse Corbin (21736578)

“…A double dagger (‡) indicates a significant decrease of mitochondrial ATP production rates (slope = −0.79 ± 0.21, <i>R</i>^<i>2</i> = 0.40, <i>F</i>(1, 22)=15.0, <i>p </i>< 0.001) from 0 to 72 ppm Ni²⁺. …”

Δ<i>guaA,</i> a mutant that lacks a cytochrome P450 monooxygenase, does not grow on guaiacol. by Claudia Castro (585495)

“…</i> Wildtype (solid black line) showed growth (OD_{600 nm}) and guaiacol degradation (blue line) beginning 24 hours post-incubation. Meanwhile, Δ<i><i>guaA</i></i> (dashed black line) never demonstrated an increase in OD_{600 nm} or significant guaiacol decrease (<i><i>n</i> </i>= 12)<i>.…”

Heterotrophic cell growth and dry cell yield of <i>Rhodovulum sulfidophilum</i> in artificial seawater (ASW) based growth medium of different salinities, wherein 100% corresponds t... by Shamitha Rao Morey-Yagi (19779981)

“…Asterisks indicate significant differences between 100% and decreasing concentrations of ASW tested using one-way ANOVA (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0321821#pone.0321821.g001" target="_blank">Figs 1b</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0321821#pone.0321821.g001" target="_blank">1c</a>) or two-way ANOVA (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0321821#pone.0321821.g001" target="_blank">Fig 1a</a>), and the Dunnett’s multiple comparison test (GraphPad Prism 9); * p < 0.05, ** p < 0.01, and *** p < 0.001.…”

Probing Field Cancerization in the Gastrointestinal Tract Using a Hybrid Raman and Partial Wave Spectroscopy Microscope by Elena Kriukova (21524544)

“…In the normal tissue of L2-IL1B mice, we demonstrate a statistically significant increase (<i>p</i> < 0.001) in Raman band intensities associated with free amino acids and a decrease in bands associated with lipids (<i>p</i> < 0.005) and carotenoids (<i>p</i> < 0.001) compared to healthy controls. …”

Probing Field Cancerization in the Gastrointestinal Tract Using a Hybrid Raman and Partial Wave Spectroscopy Microscope by Elena Kriukova (21524544)

“…In the normal tissue of L2-IL1B mice, we demonstrate a statistically significant increase (<i>p</i> < 0.001) in Raman band intensities associated with free amino acids and a decrease in bands associated with lipids (<i>p</i> < 0.005) and carotenoids (<i>p</i> < 0.001) compared to healthy controls. …”