Effect of curcumin on methotrexate-induced ovarian damage and follicle reserve in rats: the role of PARP-1 and P53 by Mete Keçeci (20479508)

“…Curcumin (Cur) is a natural polyphenol compound with powerful antioxidant and antiapoptotic effects. In this study we investigate the effects of Cur on MTX-induced ovarian damage.…”

Data Sheet 3_The characteristics of auditorial event-related potential under propofol sedation associated with preoperative cognitive performance in glioma patients.docx by Xinxin Wang (134010)

“…Compared to that in the non-MCI group, the average amplitude of the MMN component evoked by the novel stimulus significantly decreased during the recovery period in the MCI group (−3.895 ± 1.961 μV vs. -1.617 ± 1.831 μV, p = 0.003). …”

Table 7_Evaluation of cold tolerance in sorghum germplasm from the Chishui River Basin in China: insights from germination, field trials, and physiological assays.doc by Hongli Yang (170838)

“…Agronomic data collected under two early sowing conditions (severe and mild low-temperature stress) demonstrated that several germplasm accessions, like No. 12, maintained high emergence rates (97% and 100% VS. 100% in conventional sowing) and grain weight per panicle (63.3 g and 53.4 g VS. 45.9 g in conventional sowing) without significant reductions, whereas others, such as Nos. 17 and 48, showed marked decreases (P < 0.01). …”

Table 2_Ranges, temporal trend, and determinants of novel obesity indices in middle-aged and older Chinese population: insights from a nationally representative and longitudinal st... by Liufang Huang (12397954)

“…Over the five-year period, WHtR, CVAI, and LAP increased significantly (β = 0.00489, β = 4.51607, β = 6.37441; all p < 0.001), while ABSI decreased (β = −0.00048, p < 0.001). …”

Table 5_Evaluation of cold tolerance in sorghum germplasm from the Chishui River Basin in China: insights from germination, field trials, and physiological assays.doc by Hongli Yang (170838)

“…Agronomic data collected under two early sowing conditions (severe and mild low-temperature stress) demonstrated that several germplasm accessions, like No. 12, maintained high emergence rates (97% and 100% VS. 100% in conventional sowing) and grain weight per panicle (63.3 g and 53.4 g VS. 45.9 g in conventional sowing) without significant reductions, whereas others, such as Nos. 17 and 48, showed marked decreases (P < 0.01). …”

Table 6_Evaluation of cold tolerance in sorghum germplasm from the Chishui River Basin in China: insights from germination, field trials, and physiological assays.doc by Hongli Yang (170838)

“…Agronomic data collected under two early sowing conditions (severe and mild low-temperature stress) demonstrated that several germplasm accessions, like No. 12, maintained high emergence rates (97% and 100% VS. 100% in conventional sowing) and grain weight per panicle (63.3 g and 53.4 g VS. 45.9 g in conventional sowing) without significant reductions, whereas others, such as Nos. 17 and 48, showed marked decreases (P < 0.01). …”

Data Sheet 1_Effects of Th1/Th17 and Th2 cytokines on lipid metabolism in differentiated keratinocytes.zip by Alessia Cavallo (13036581)

“…Introduction<p>Abnormalities of keratinocyte differentiation and impairment of permeability barrier are features of inflammatory skin diseases driven by Th1/Th17 and Th2 immune response, such as psoriasis and atopic dermatitis. We aimed at identifying the signature of the Th1/Th17 and Th2 environments on keratinocytes, focusing on the expression of genes involved in the lipid metabolism and profiles of abundance of lipid metabolites.…”

Image 2_Kidney sparing surgery versus radical nephroureterectomy in upper tract urothelial carcinoma: a meta-analysis and systematic review.tif by Leqing Zhou (20981021)

“…In the comparison between the endoscopic management (EM) and RNU groups, EM was associated with worse overall survival outcomes (HR,1.40; 95%CI,1.08-1.82; P=0.01) based on multivariable Cox regression analysis, and the upper tract recurrence rate (OR,39.06; 95%CI, 14.55-104.85; P<0.00001) was significantly higher in the EM group. On the other hand, in patients treated with KSS, postoperative renal function as measured by eGFR increased by 0.4ml/min/1.73 m², while it decreased by 11.4ml/min/1.73 m² in the RNU group (WMD, 11.81 ml/min/1.73 m²; 95%CI,9.06-14.56; P<0.0001).…”

Data Sheet 1_What regulates decomposition in agroecosystems? Insights from reading the tea leaves.pdf by Marshall D. McDaniel (4341325)

“…Despite this importance, we still lack a good understanding of local factors that regulate decomposition, especially in agroecosystems where management plays an outsized role. …”

Table 1_The real-world safety of Nivolumab: a pharmacovigilance analysis based on the FDA adverse event reporting system.docx by Yutong Wu (3130584)

“…Notably, we detected several potential safety signals not currently listed in the prescribing information: Malignant neoplasm progression, weight decreased, sepsis myocarditis, encephalitis and hypotension.…”

Data Sheet 1_Cytosolic phospholipase A2 links tau pathology to insulin signaling impairment in Alzheimer’s disease.pdf by Faruk Hossen (20275670)

“…Specifically, we found significant decreases in insulin receptor-α (IR-α) and insulin receptor-β (IR-β) expression, along with increased levels of phospho-insulin receptor substrate 1 at Ser307 [p-IRS-1 (Ser307)] and decreased levels of p-IRS-1 (Tyr895), compared to wild-type (WT) mice. …”

Image 1_L1, a 3,3′-diindolylmethane-derivative, induced ER stress-mediated apoptosis and suppressed growth through the FLI1/AKT pathway in erythroleukemia HEL cells.tif by Yi Kuang (1873354)

“…Moreover, FLI1 is a crucial target for mediating cell differentiation, apoptosis, inflammation and displays abnormal expression in HEL cells. Here, we showed that the protein expression levels of FLI1 and AKT/p-AKT decreased with L1 treatment and that the RNA expressions of their downstream genes GATA1, TFRC, GYPA, CDKN1A and CDKN1B were also regulated by L1.…”

Image 2_L1, a 3,3′-diindolylmethane-derivative, induced ER stress-mediated apoptosis and suppressed growth through the FLI1/AKT pathway in erythroleukemia HEL cells.tif by Yi Kuang (1873354)

“…Moreover, FLI1 is a crucial target for mediating cell differentiation, apoptosis, inflammation and displays abnormal expression in HEL cells. Here, we showed that the protein expression levels of FLI1 and AKT/p-AKT decreased with L1 treatment and that the RNA expressions of their downstream genes GATA1, TFRC, GYPA, CDKN1A and CDKN1B were also regulated by L1.…”

Additional file 6 of NSDHL contributes to breast cancer stem-like cell maintenance and tumor-initiating capacity through TGF-β/Smad signaling pathway in MCF-7 tumor spheroid by So-Hyun Yoon (5353250)

“…Supplementary Material 6: Figure S6. A-83-01 (50 µM) decreased the phosphorylation of both SMAD2 and SMAD3 but did not show significant toxicity in MCF-7-spheroids. …”

Glial 5-HT_2a receptors are necessary and rate limiting for experience-dependent synaptic glomeruli pruning. by Vanessa Kay Miller (19775496)

“…All the individual data points are shown with mean ± SEM. Significance is indicated as <i>p</i> < 0.0001 (****) and <i>p</i> > 0.05 (not significant, ns). …”

Cell surface sialic acid is not required for SARS-CoV-2 spike glycoprotein binding. by Kimberley C. Siwak (20378620)

“…Statistical significance was assessed by two-way ANOVA (****p<0.0001; ns, not significant).…”

Table 1_Perioperative neurocognitive disorder in colorectal cancer surgery: a systematic review of incidence, mechanisms, and interventions.doc by Xiujin Huang (22637270)

“…Key risk factors included advanced age (mean 63–76 years), ASA status II–III, and open surgery. …”

Supplementary file 1_Modulatory effects of transcranial direct current stimulation on sensory gating in Fibromyalgia Syndrome.docx by Juan L. Terrasa (5506691)

“…</p>Methods<p>Thirty-nine female Fibromyalgia Syndrome patients (43–71 years, mean 55.56 ± 7.85) participated in the study and were randomly assigned to the active transcranial direct current stimulation (n = 17) or non-electrical stimulation (sham; n = 22). …”

Table 1_Overcoming tet(X)-harboring tigecycline resistance: a study on the efficacy of tigecycline-apramycin combinations.docx by Juan Liu (6492)

“…</p>Methods<p>In this study, we evaluated the synergism of tigecycline combining with other antibiotics as a means of overcoming the tet(X)-mediated resistance in Acinetobacter spp. …”

Table 2_Untargeted metabolic analysis in serum samples reveals metabolic signature in children with congenital heart failure on enalapril therapy.csv by N. J. L. Smeets (21188726)

“…Additionally, we investigated metabolic profiles in CHD patients and healthy controls.…”