Discovery of an Orally Active PDE1 Inhibitor for Disease-Modifying Treatment of Postmenopausal Osteoporosis via Dual Anabolic-Antiresorptive Mechanisms by Farman M. Abbasi (22318766)

“…In ovariectomized mice, <b>5cc</b> administration (5 mg/kg) improved the trabecular microarchitecture, bone mineral density, and strength, at levels comparable to teriparatide, while significantly reducing bone resorption markers. With 13.57% oral bioavailability and selectivity for PDE1A1 (32% inhibition at 500 nM), <b>5cc</b> offers an innovative therapeutic candidate for PMO with a dual anabolic-antiresorptive profile and oral efficacy, warranting further clinical development.…”

Discovery of an Orally Active PDE1 Inhibitor for Disease-Modifying Treatment of Postmenopausal Osteoporosis via Dual Anabolic-Antiresorptive Mechanisms by Farman M. Abbasi (22318766)

“…In ovariectomized mice, <b>5cc</b> administration (5 mg/kg) improved the trabecular microarchitecture, bone mineral density, and strength, at levels comparable to teriparatide, while significantly reducing bone resorption markers. With 13.57% oral bioavailability and selectivity for PDE1A1 (32% inhibition at 500 nM), <b>5cc</b> offers an innovative therapeutic candidate for PMO with a dual anabolic-antiresorptive profile and oral efficacy, warranting further clinical development.…”

Discovery of an Orally Active PDE1 Inhibitor for Disease-Modifying Treatment of Postmenopausal Osteoporosis via Dual Anabolic-Antiresorptive Mechanisms by Farman M. Abbasi (22318766)

“…In ovariectomized mice, <b>5cc</b> administration (5 mg/kg) improved the trabecular microarchitecture, bone mineral density, and strength, at levels comparable to teriparatide, while significantly reducing bone resorption markers. With 13.57% oral bioavailability and selectivity for PDE1A1 (32% inhibition at 500 nM), <b>5cc</b> offers an innovative therapeutic candidate for PMO with a dual anabolic-antiresorptive profile and oral efficacy, warranting further clinical development.…”

RSA results across a broader frequency band (0.1–150 Hz). by Pengcheng Lv (7609706)

“…<p><b>(A)</b> For the translation epochs from good trials, the similarity of Same Context was significantly greater than the similarity of Different Context in HC. …”

FAT1 interacts with the E3 ligase MIB2. by Rui Li (4631)

Molecular Logic Gate for Sensing pH/Peroxynitrite with Potential Applications in Cisplatin Treatment by Lifang Guo (1460884)

“…With this probe, the significant roles of pH and ONOO^– in cisplatin treatment are disclosed, in which the cell account shows a dramatic reduction accompanied by decreased pH and upregulated ONOO^– levels. …”

Primer pairs for RT-qPCR. by Yoichi Kurokawa (22290520)

“…Conversely, exposure to endogenous prooxidants (dopamine and adrenaline), certain food-derived polyphenols (chrysin and 3-<i><i>O</i></i>-methylquercetin), or 1,2-naphthoquinone led to a significant decrease (<0.5-fold) in Rmst expression. …”

RT-qPCR data tables. by Yoichi Kurokawa (22290520)

“…Conversely, exposure to endogenous prooxidants (dopamine and adrenaline), certain food-derived polyphenols (chrysin and 3-<i><i>O</i></i>-methylquercetin), or 1,2-naphthoquinone led to a significant decrease (<0.5-fold) in Rmst expression. …”

Inc exhibits key properties of a Cul3 adaptor in neurons in vivo. by Qiuling Li (390393)

“…Neuronal <i>Cul3</i> RNAi decreases <i>Cul3</i> transcript levels but does not significantly alter those of <i>inc</i>. …”

Citation patterns of Cochrane Reviews and other systematic reviews: a bibliometric analysis by Louise Olsbro Rosengaard (20439098)

“…The time window in which systematic reviews received citations has been progressively decreasing, possibly indicating a trend toward quicker recognition and uptake of these reviews within the academic community. …”

Certainty of affect predicted by valence and low, medium, and, high trait emotional clarity Predicted certainty of knowing how you feel in a trial, as predicted by the subject’s st... by Anthony G. Vaccaro (5964368)

Cascara Pulp: A Novel Ingredient for Healthy Kombucha by Using Honey and Brown Sugar by Wanlapa Lorliam (12523628)

“…Cascara kombucha with 15% brown sugar had significantly lower acetic acid content and higher brix as compared with 5% and 10% honey. …”

Categorisation of districts based on type of correlation observed and results of Moran’s local test for spatial correlation of coefficients and lags. by Gabriel Carrasco-Escobar (794055)

Basic features of microtopography. by Qingping Gou (22641045)

“…The results showed that: the difference of shallow soil moisture in different microtopographies on a slope surface was not significant, the difference of deep soil moisture was significant, and the soil moisture overuse was the largest in the gully (GU), amounting to 386.36 mm, and the smallest in the ephemeral gully (EG) (131.02 mm); the GU, the sink hole (SH), and the scarp (SC) showed a trend of decreasing and then increasing with the increase of soil depth, and the platform (PL) has little overall trend of change in soil moisture with the increase of soil depth, and the soil moisture of US and EG shows the trend of “decreasing-then increasing-then decreasing” with the increase of soil depth. …”

Soil bulk density of different microtopographies. by Qingping Gou (22641045)

“…The results showed that: the difference of shallow soil moisture in different microtopographies on a slope surface was not significant, the difference of deep soil moisture was significant, and the soil moisture overuse was the largest in the gully (GU), amounting to 386.36 mm, and the smallest in the ephemeral gully (EG) (131.02 mm); the GU, the sink hole (SH), and the scarp (SC) showed a trend of decreasing and then increasing with the increase of soil depth, and the platform (PL) has little overall trend of change in soil moisture with the increase of soil depth, and the soil moisture of US and EG shows the trend of “decreasing-then increasing-then decreasing” with the increase of soil depth. …”

Distribution of study areas. by Jie Zhang (64655)

“…(main findings) The results show the following: (1) the primary term of government innovation preferences has a positive effect on the ecological resilience of resource-based cities, and the secondary term has a negative effect, with a decreasing marginal effect. …”

Descriptive statistics of variables. by Jie Zhang (64655)

“…(main findings) The results show the following: (1) the primary term of government innovation preferences has a positive effect on the ecological resilience of resource-based cities, and the secondary term has a negative effect, with a decreasing marginal effect. …”

Code. by Jie Zhang (64655)

“…(main findings) The results show the following: (1) the primary term of government innovation preferences has a positive effect on the ecological resilience of resource-based cities, and the secondary term has a negative effect, with a decreasing marginal effect. …”

Schematic of the conclusions. by Jie Zhang (64655)

“…(main findings) The results show the following: (1) the primary term of government innovation preferences has a positive effect on the ecological resilience of resource-based cities, and the secondary term has a negative effect, with a decreasing marginal effect. …”

Robustness test. by Jie Zhang (64655)

“…(main findings) The results show the following: (1) the primary term of government innovation preferences has a positive effect on the ecological resilience of resource-based cities, and the secondary term has a negative effect, with a decreasing marginal effect. …”