Combating Chemoresistance in Breast Cancer: Exploring Tumor Microenvironment, Combination Therapies, and Drug Repurposing Strategies by Shazia Sofi (17764488)

“…Chemoresistance in cancer can arise from a variety of molecular mechanisms, including active drug expulsion (drug efflux), decreased drug uptake, enhanced DNA repair mechanisms, the ability of cancer cells to evade programmed cell death (apoptosis), the diversity in the population of cancer cells within a tumor (tumor heterogeneity), and significant alterations in the tumor microenvironment (TME), where interactions between cancer cells, cancer-associated fibroblasts, immune cells, and the extracellular matrix contribute to a supportive environment that allows tumors to survive treatment and escape therapy. …”

Table 1_Psychometric analysis of the social connectedness instrument.docx by Brian Kelley (1271004)

“…Introduction<p>Social connectedness is decreasing, especially among young adults, which poses a significant public mental and physical health threat globally. …”

Supplemental Tables S1-S5 by Kevin Gries (21956942)

“…These findings indicate that a single day of reduced physical activity can elicit modest but significant changes in the metabolic and transcriptomic exercise response. …”

Table 1_Global burden of disease changes related to high red meat diets and breast cancer from 1990 to 2021 and its prediction up to 2030.docx by Yujun Tong (6179414)

“…Stratification by Socio-Demographic Index (SDI) revealed a significant decline in disease burden in high-SDI regions, while the ASR in low-SDI regions trended upward. …”

Image 7_Systemic immune inflammatory index and mortality in chronic kidney disease.tif by Yanshuang Ma (22176478)

“…Higher SII levels correlated with decreased survival and longevity. In CKD patients over 45 years, SII reliably predicted all-cause mortality (statistically significant) and was linked to cardiovascular and cancer deaths (not statistically significant).…”

Image 2_Systemic immune inflammatory index and mortality in chronic kidney disease.tif by Yanshuang Ma (22176478)

“…Higher SII levels correlated with decreased survival and longevity. In CKD patients over 45 years, SII reliably predicted all-cause mortality (statistically significant) and was linked to cardiovascular and cancer deaths (not statistically significant).…”

Image 3_Systemic immune inflammatory index and mortality in chronic kidney disease.tif by Yanshuang Ma (22176478)

“…Higher SII levels correlated with decreased survival and longevity. In CKD patients over 45 years, SII reliably predicted all-cause mortality (statistically significant) and was linked to cardiovascular and cancer deaths (not statistically significant).…”

Image 4_Systemic immune inflammatory index and mortality in chronic kidney disease.tif by Yanshuang Ma (22176478)

“…Higher SII levels correlated with decreased survival and longevity. In CKD patients over 45 years, SII reliably predicted all-cause mortality (statistically significant) and was linked to cardiovascular and cancer deaths (not statistically significant).…”

Image 5_Systemic immune inflammatory index and mortality in chronic kidney disease.tif by Yanshuang Ma (22176478)

“…Higher SII levels correlated with decreased survival and longevity. In CKD patients over 45 years, SII reliably predicted all-cause mortality (statistically significant) and was linked to cardiovascular and cancer deaths (not statistically significant).…”

Image 1_Systemic immune inflammatory index and mortality in chronic kidney disease.tiff by Yanshuang Ma (22176478)

“…Higher SII levels correlated with decreased survival and longevity. In CKD patients over 45 years, SII reliably predicted all-cause mortality (statistically significant) and was linked to cardiovascular and cancer deaths (not statistically significant).…”

Image 6_Systemic immune inflammatory index and mortality in chronic kidney disease.tif by Yanshuang Ma (22176478)

“…Higher SII levels correlated with decreased survival and longevity. In CKD patients over 45 years, SII reliably predicted all-cause mortality (statistically significant) and was linked to cardiovascular and cancer deaths (not statistically significant).…”

Unveiling the molecular legacy of transient insulin resistance: Implications for hepatic metabolic adaptability (Sup Tables). Berthier et al. J. Hepatol. 2025 by Alexandre Berthier (16876311)

“…</p><h3>Results</h3><p dir="ltr">Our study shows that temporarily blocking the insulin receptor in young mice leads to later-life liver issues by hindering PPARα-mediated adaptation to a high-fat diet. This is linked to decreased histone active marks at PPARα sites and reduced endogenous PPARα ligands. …”

Supplementary file 1_Collaborative optimal operation control of HVAC systems based on multi-agent.docx by Chen Fu (165356)

“…<p>The HVAC system of public buildings, as a thermostatically controlled load, accounting for a relatively significant proportion of building energy consumption. …”

<b><i>N</i></b>^{<strong>6</strong>}<b>-Methyladenosine demethylase FTO controls</b><b>macrophage homeostasis in diabetic vasculopathy</b> by Siguo Feng (19924429)

“…<p dir="ltr"><b>Abstract</b></p><p dir="ltr">Diabetic vasculopathy, encompassing complications such as diabetic retinopathy, represents a significant source of morbidity, with inflammation playing a pivotal role in the progression of these complications. …”

Alcohol perceptions and driving decisions among adolescents: Exploring the role of peer and parental influences in Virginia by Asmaa Namoos (21304297)

“…Though parent distracted driving positively influenced adolescent driving behavior, this effect was not statistically significant (coefficient = 0.008, <i>P</i> = .320).</p> <p>The findings indicate a significant reduction in risky behaviors such as drinking and driving and an increase in seat belt use among adolescents. …”

Data Sheet 1_Successional patterns of microbial communities across various stages of leaf litter decomposition in poplar plantations.pdf by Shuang Hu (182425)

“…With the decomposition of leaf litter, the total N content increased gradually, while other nutrients (C, P, K, cellulose and hemicellulose) decreased progressively. Litter characteristics had significant effects on microbial community structure: C/N, TK and residual hemicellulose (RH) were the primary driving factors affecting fungal community structure, whereas bacterial community structure was influenced by TK, RH, residual cellulose (RC) and lignin contents.…”

Table 1_CyTOF reveals platelet subtype changes predicting the efficacy of combined immunotherapy and targeted therapy in liver cancer.docx by Wenjing Wang (181404)

“…However, some patients still exhibit poor therapeutic outcomes. Platelets, as a critical component of blood, play a significant role in liver cancer progression by influencing angiogenesis and the tumor immune microenvironment.…”

GPCR kinase, <i>Ppa</i>-GRK-2 is required for light avoidance. by Kenichi Nakayama (2354653)

“…<i>Ppa-grk-2</i> mutants had decreased light avoidance. One-way ANOVA, Dunnett’s multiple comparison tests, compared with wild type. n.s = not significant, ***<i>P</i> < 0.001, ****<i>P</i> < 0.0001.…”

Figure 1 from Combined Oxygen-Enhanced MRI and Perfusion Imaging Detect Hypoxia Modification from Banoxantrone and Atovaquone and Track Their Differential Mechanisms of Action by James P.B. O’Connor (15037863)

“…<b>F,</b> Under hypoxia (3% O₂), OCR ablation was observed at 1 µmol/L atovaquone and while a trend toward reduced OCR was observed for banoxantrone this was not significant.…”

Table 1_Unraveling the anti-inflammatory effects of Mediterranean diet in patients with cancer remission.xlsx by Michele Francesco Di Tolla (12503167)

“…After dietary intervention, a significant reduction in specific inflammatory and metabolic biomarkers was observed, with distinct effects depending on tumor type. …”