Table 1_Cancer-associated fibroblasts gene signature: a novel approach to survival prediction and immunotherapy guidance in colon cancer.docx حسب Wenbing Zhang (152972)

"…A higher immune infiltration rate and lower IC50 values of anticancer drugs were significant in the high-risk group. …"

Table 1_Research on the changes in the disease burden of nasopharyngeal carcinoma caused by global occupational formaldehyde exposure from 1990 to 2021 and prediction of future tre... حسب Tingting Duan (5181482)

"…From the perspective of the socio-demographic index (SDI), the disease burden is most severe in regions with lower SDI. Geographically, there are significant differences in the disease burden among different countries and regions, with South Asia, East Asia, and Africa having the highest disease burden. …"

Table 2_Cancer-associated fibroblasts gene signature: a novel approach to survival prediction and immunotherapy guidance in colon cancer.xlsx حسب Wenbing Zhang (152972)

"…A higher immune infiltration rate and lower IC50 values of anticancer drugs were significant in the high-risk group. …"

Image 1_Cancer-associated fibroblasts gene signature: a novel approach to survival prediction and immunotherapy guidance in colon cancer.tif حسب Wenbing Zhang (152972)

"…A higher immune infiltration rate and lower IC50 values of anticancer drugs were significant in the high-risk group. …"

Analyzing the global burden of 11 subtypes of congenital birth defects: trends, sociodemographic correlates, and outcomes from 1990 to 2021 حسب Enhui Yang (11844002)

"…The findings advocate for enhanced prevention and management strategies specifically designed for regions with lower SDIs.</p> <p></p><p>The prevalence, mortality, and DALYs attributable to congenital birth defects (CBDs) significantly decreased globally from 1990 to 2021, though notable regional disparities persist.…"

Image 1_Changes in insulin resistance and other metabolic parameters during home quarantine amid the COVID-19 pandemic among the general population.jpeg حسب Yuting Zhang (337082)

"…Compared to before home quarantine, the TyG (6.80 ± 0.58 vs. 6.83 ± 0.58, p < 0.001), TyG-BMI (158.30 ± 31.92 vs. 159.48 ± 31.73, p < 0.001), and TyG-WC (533.53 ± 103.15 vs. 535.78 ± 103.65, p = 0.039) increased significantly after the home quarantine. Besides, glucose, lymphocyte, and platelet decreased significantly while BMI, systolic blood pressure, diastolic blood pressure, pulse, total cholesterol, triglyceride, high-density lipoprotein, low-density lipoprotein, uric acid, red blood cell, and monocyte also increased significantly after home quarantine (all p < 0.05).…"

Table1_Tle6 deficiency in male mice led to abnormal sperm morphology and reduced sperm motility.docx حسب Kousuke Kazama (19937214)

"…In addition, Tle6^+/− mice exhibited a significant increase in serum testosterone levels compared to wild-type mice. …"

Supplementary Material for: Role of melatonin in intestinal mucosal injury induced by chronic restraint stress in mice حسب figshare admin karger (2628495)

"…Results: Mice subjected to restraint stress presented elevated CORT and NE levels of 141.41% and 151.24%, respectively, and a decreased plasma MT content of 37.12%. Consistent with the decrease in MT levels, we observed a reduction in antioxidant ability and autophagic proteins and increased apoptotic protein levels in the gut, resulting in injury to the intestinal mucosa, which manifested as reductions in the villus height and the V/C ratio; the number of goblets; the number of mast and PCNA-positive cells; and the expression of tight junction proteins (ZO-1, occludin and claudin-1). …"

Supplementary Material for: Acute myelin oligodendrocyte glycoprotein (MOG)-IgG optic neuritis without optic nerve enhancement حسب Jeyanathan B. (20374227)

"…While acute MOG-ON usually presents with optic nerve enhancement, recognizing atypical presentations is critical in accurate diagnosis and effective management. Case Presentation: We herein present a case of a 67-year-old woman presenting with sudden decrease in vision in the right eye. …"

Table 1_Antimicrobial susceptibility profiles of commensal Clostridium perfringens isolates from chickens in Hungarian poultry farms between 2022 and 2023.docx حسب Ádám Kerek (14263613)

"…</p>Methods<p>In this study, we aimed to assess the antibiotic susceptibility of commensal Clostridium perfringens (C. perfringens) strains (n = 146) isolated from largescale poultry farms in Hungary, using minimum inhibitory concentration (MIC) determinations. …"

Table1_Bidirectional two-sample Mendelian randomization analysis investigates causal associations between cathepsins and inflammatory bowel disease.DOCX حسب Na Wang (193263)

"…</p>Results<p>The forward MR analyses showed no significant association between cathepsins and IBD. …"

Video 2_Progressive encephalomyelitis with rigidity and myoclonus after thymectomy in a woman with myasthenia gravis.mp4 حسب Lixia Qin (3358520)

"…The patient was treated with intravenous methylprednisolone, oral clonazepam, and tacrolimus, which resulted in significant clinical improvement. A 2-year follow-up demonstrated sustained recovery, accompanied by a decrease in GAD65 antibody titers. …"

Data Sheet 1_Non-stationary response of Pacific saury (Cololabis saira) in the northwestern Pacific to climate variability.docx حسب Chang Cao (2592700)

"…The dynamics of Pacific saury from 1970 to 2021 could be divided into four periods: the 1970s and 1980s when the Siberian High and the intensification of the East Asian winter monsoon drove down the water temperature, providing a suitable habitat and resulting in an increase in resource abundance; In the 1990s, the rise in temperature led to a reduction in resource abundance; At the beginning of the 21st century, the enhancement of the Siberian High brought about a suitable habitat, and the resource abundance showed a significant increase; The unfavorable high water temperature environment in the 2010s caused the resource abundance to decrease once again. …"

DataSheet1_Bidirectional two-sample Mendelian randomization analysis investigates causal associations between cathepsins and inflammatory bowel disease.DOCX حسب Na Wang (193263)

"…</p>Results<p>The forward MR analyses showed no significant association between cathepsins and IBD. …"

Video 1_Progressive encephalomyelitis with rigidity and myoclonus after thymectomy in a woman with myasthenia gravis.mp4 حسب Lixia Qin (3358520)

"…The patient was treated with intravenous methylprednisolone, oral clonazepam, and tacrolimus, which resulted in significant clinical improvement. A 2-year follow-up demonstrated sustained recovery, accompanied by a decrease in GAD65 antibody titers. …"

Image 1_Low hydrostatic pressure promotes functional homeostasis of nucleus pulposus cells through the TRPV4/CRT/FA complex axis.tiff حسب Junxian Hu (8158044)

"…CRT also exhibits distinct roles depending on its subcellular localization. In this study, we observed that under low hydrostatic pressure, TRPV4 activation and subsequent calcium influx led to an increase in CRT synthesis and a significant rise in its cytosolic expression. …"

DataSheet2_Bidirectional two-sample Mendelian randomization analysis investigates causal associations between cathepsins and inflammatory bowel disease.DOCX حسب Na Wang (193263)

"…</p>Results<p>The forward MR analyses showed no significant association between cathepsins and IBD. …"

Image 1_Multi-omics analysis reveals neutrophil heterogeneity and key molecular drivers in sepsis-associated acute kidney injury.jpg حسب Tianle Cheng (20788417)

"…This study employed a multi-omics approach, integrating single-cell and bulk RNA sequencing from 21 sepsis samples and Escherichia coli-induced sepsis datasets, alongside bioinformatics, machine learning, and experimental validation in a rat model and human peripheral blood. We identified four neutrophil subtypes—pro-inflammatory, anti-inflammatory, mature, and immature—revealing a significant increase in pro-inflammatory neutrophils in sepsis (40.53% versus 4.19% in controls) and a decrease in anti-inflammatory neutrophils (18.43% versus 27.04%). …"

Image 2_Multi-omics analysis reveals neutrophil heterogeneity and key molecular drivers in sepsis-associated acute kidney injury.jpg حسب Tianle Cheng (20788417)

"…This study employed a multi-omics approach, integrating single-cell and bulk RNA sequencing from 21 sepsis samples and Escherichia coli-induced sepsis datasets, alongside bioinformatics, machine learning, and experimental validation in a rat model and human peripheral blood. We identified four neutrophil subtypes—pro-inflammatory, anti-inflammatory, mature, and immature—revealing a significant increase in pro-inflammatory neutrophils in sepsis (40.53% versus 4.19% in controls) and a decrease in anti-inflammatory neutrophils (18.43% versus 27.04%). …"

Data Sheet 1_Low hydrostatic pressure promotes functional homeostasis of nucleus pulposus cells through the TRPV4/CRT/FA complex axis.zip حسب Junxian Hu (8158044)

"…CRT also exhibits distinct roles depending on its subcellular localization. In this study, we observed that under low hydrostatic pressure, TRPV4 activation and subsequent calcium influx led to an increase in CRT synthesis and a significant rise in its cytosolic expression. …"