Video 7_Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC.mp4 by Lina Ouologuem (22489549)

“…</p>Methods<p>To investigate the role of the endolysosomal two-pore channel 2 (TPC2) in HCC, we employed genetic and pharmacological approaches, including TPC2 knockout (KO) and pharmacological inhibition using SG094. …”

Statistical data. by Bo Yang (104813)

“…The results show that: (1) Habitat quality shows significant gradient characteristics, and the overall decreases from southeast to northwest. …”

Sensitivity of land types to threat factors. by Bo Yang (104813)

“…The results show that: (1) Habitat quality shows significant gradient characteristics, and the overall decreases from southeast to northwest. …”

Table 1_Optimal fertilizer rate and sowing density can improve oat quality, yield and N and P comprehensive efficiency in the Loess Plateau of China.docx by Ruochen Zhang (3434996)

“…In order to compare N/P efficiency more intuitively, we combined N/P content, N/P uptake, N/P uptake efficiency and N/P recover efficiency to calculate N/P comprehensive efficiency.…”

Supplementary Material for: Minimal Change Disease and Focal Segmental Glomerulosclerosis are associated with good kidney prognosis and Thrombotic Microangiopathy with poor kidney... by Neves P.D.M.M. (20408168)

“…The kidney is a frequent target of SARS-CoV-2, potentially developing lesions in glomeruli, vessels, and tubulointerstitium in response to this infection. Herein we present the analysis of the first large Latin American cohort of adult patients undergoing kidney biopsy due to COVID-19-associated kidney disorders. …”

Repetitive stress modulates loudness perception. by Ghattas Bisharat (20706928)

“…(c) Perceptual boundaries in different conditions. We define the perceptual boundary as the intensity where the psychometric fit to the choice function, crosses PLoud = 0.5. …”

Table 1_Mutations in ace2 gene modulate cytokine levels and alter immune responses in Mycobacterium tuberculosis and SARS-CoV-2 co-infection: a Cameroonian cohort.docx by Mary Ngongang Kameni (20924126)

“…Our most significant findings include the association of double mutant alleles (AA) of rs4646140 and rs2074192 in the ace2 gene with decreased IL-6 and IL-2 expression levels respectively in TB-COVID-19 participants. …”

DataSheet1_The β2-adrenergic biased agonist nebivolol inhibits the development of Th17 and the response of memory Th17 cells in an NF-κB-dependent manner.docx by Mehri Hajiaghayi (19822665)

“…</p>Results<p>Nebivolol treatment decreased IL-17A and IFN-γ secretion by activated memory Th cells and elevated IL-4 levels. …”

<i>mig-21</i> sensitizes adult DTCs to polarizing signals. by Xin Li (51274)

“…A robust “extra turn” defect rate of control on <i>vab-3</i> RNAi (n=38/57) decreases with <i>mig-21(u787)</i> on <i>vab-3</i> RNAi (n=24/65), p < 0.01. …”

KIF5A-dependent axonal transport deficiency disrupts autophagic flux in trimethyltin chloride-induced neurotoxicity by Mengyu Liu (2890397)

“…<p>Trimethyltin chloride (TMT) is widely used as a constituent of fungicides and plastic stabilizers in the industrial and agricultural fields, and is generally acknowledged to have potent neurotoxicity, especially in the hippocampus; however, the mechanism of induction of neurotoxicity by TMT remains elusive. Herein, we exposed Neuro-2a cells to different concentrations of TMT (2, 4, and 8 μM) for 24 h. …”

The Effect of Chronic Stress on Apoptosis Regulation and Oncogenesis Evolution: A Theoretical Approach. by DIMITRIOS KIMOGLOU (20499350)

“…<br>Chronic stress disrupts the apoptotic process and contributes to<br>tumorigenesis. In particular, we seek to illustrate the epigenetic influence of stress on genes that control apoptosis, as well as the significance of the HPA axis as a therapeutic target for restoring cellular equilibrium. …”

<b>Distributed Hydraulic Micro-Cooling (MHD): A Low-Cost, High-Impact Urban Heat Mitigation Strategy</b> / <b>Enfriamiento Hidráulico Micro-Distribuido (MHD): Estrategia Urbana de... by Ricardo Riveros (22484566)

“…Large thermal masses such as roofs, asphalt roads, and concrete structures store significant amounts of solar radiation during the day (up to 1200–1600 MJ/m²). …”

LRIG1 and CDK6 expression in the lateral ventricular wall cells by Hyung-song Nam (8914220)

“…Although the <i>Cdk6</i> mRNA decreases significantly in the neuroblasts, the DCX+ neuroblasts still show a lot of td-sfGFP immunoreactivity.…”

Supplementary Material for: A Case Report of Intravitreal Aflibercept for Iris Metastasis from Small Cell Lung Carcinoma with Neovascular Glaucoma by figshare admin karger (2628495)

“…While the prognosis of patients with metastatic iris tumors remains poor, intravitreal aflibercept injections show potential in reducing iris tumor size and lowering IOP. Although not curative, this therapeutic approach may play a significant role in the symptom management of these patients.…”

Data Sheet 1_Elucidating the mechanism of stigmasterol in acute pancreatitis treatment: insights from network pharmacology and in vitro/in vivo experiments.pdf by Xuanlin Zhao (20466980)

“…Stigmasterol, a natural plant sterol found in various herbs and vegetables, exhibits a significant anti-inflammatory, antioxidant, and cholesterol-lowering effects. …”

Table 1_Improved medical protective clothing comfort for medical staff facing high-intensity infectious diseases.docx by Cheng-teng Jiang (22028945)

“…</p>Results<p>Comparative assessments revealed that the new MPC enhanced air permeability to 120 mm/s, reduced sweating by 30%, decreased skin temperature by 1.2°C, and lowered the incidence of skin maceration by 45%. …”

Table 1_Perioperative neurocognitive disorder in colorectal cancer surgery: a systematic review of incidence, mechanisms, and interventions.doc by Xiujin Huang (22637270)

“…Background<p>Perioperative neurocognitive disorder (PND) represents a significant impediment to postoperative recovery in patients undergoing colorectal cancer surgery, particularly among the elderly. …”

Preeclamptic plasma disrupts endothelial function and promotes inflammation in endothelial cells: beneficial effects of glibenclamide and MCC950 in this scenario by Karoliny Nune Santos (21752603)

“…Both GB and MCC950 reduced NLRP3 inflammasome activation and its related effects in ECs exposed to PE plasma, including lowered IL-1β, caspase-1, modulated adhesion molecules expression, as well as decreased ROS and cytotoxicity. …”

Data Sheet 1_Cannabinoid receptor 2 selective agonist ameliorates adjuvant-induced arthritis by modulating the balance between Treg and Th17 cells.docx by Na Tian (296333)

“…</p>Results<p>HU-308 reduced paw swelling, lowered spleen index, and preserved joint integrity in AIA mice, mitigating inflammatory cell infiltration and bone erosion. …”

DataSheet1_Strict biennial lifecycle and anthropogenic interventions affect temporal genetic differentiation in the endangered endemic plant, Pedicularis hallaisanensis.docx by Seongjun Kim (1993465)

“…Other cluster analyses also showed that a microhabitat under historical anthropogenic interventions contained lowered genetic diversity due to a decreased genetic distance between odd-year and even-year flowering cohorts (p < 0.05). …”