Supplementary Material for: Preliminary efficacy, tolerability, and safety analysis of Darolutamide for metastatic castration‑resistant prostate cancer: a single-center, open-label... by Yu J. (3610580)

“…The median time to PSA50 in the Darolutamide group was 1.5 months (95%CI 0.2619- 0.9545), significantly lower than that in the placebo group (3.0 months [95%CI 1.048- 3.818], p= 0.0259); The median time to PSA90 in the experimental group was 4 months (95%CI 0.3094- 1.437), 2 months shorter than that in the placebo group (6.0 months [95%CI 0.6961- 3.232]).With the median follow-up of 6 months, , the median decrease in serum PSA was -81.8% (range -60.4 to -99.9%) in the Darolutamide group and -69.4% (range -50.3 to -89.6%) in the placebo group. …”

Table 4_Association between cardiovascular health and markers of liver function: a cross-sectional study from NHANES 2005–2018.docx by Huang Yu (5882174)

“…Weighted quantile sum (WQS) regression and quantile g-computation (QGC) analyses were employed to evaluate the association between CVH and liver function markers.</p>Results<p>Linear regression analysis showed that each 1-point increase in CVH score was significantly associated with decreased levels of liver enzymes [ALT: −0.200 U/L (95% CI: −0.223, −0.176), AST: −0.043 U/L (−0.062, −0.024), GGT: −0.453 U/L (−0.509, −0.397), ALP: −0.310 U/L (−0.340, −0.281)] and increased levels of albumin [0.040 g/dL (0.036, 0.045)] and AST/ALT ratio [0.0056 (0.0051, 0.0061)]. …”

Table 2_Association between cardiovascular health and markers of liver function: a cross-sectional study from NHANES 2005–2018.docx by Huang Yu (5882174)

“…Weighted quantile sum (WQS) regression and quantile g-computation (QGC) analyses were employed to evaluate the association between CVH and liver function markers.</p>Results<p>Linear regression analysis showed that each 1-point increase in CVH score was significantly associated with decreased levels of liver enzymes [ALT: −0.200 U/L (95% CI: −0.223, −0.176), AST: −0.043 U/L (−0.062, −0.024), GGT: −0.453 U/L (−0.509, −0.397), ALP: −0.310 U/L (−0.340, −0.281)] and increased levels of albumin [0.040 g/dL (0.036, 0.045)] and AST/ALT ratio [0.0056 (0.0051, 0.0061)]. …”

Passive mapping of hand motor cortex across altered states of consciousness by Yusheng Tong (6183350)

“…The slope coefficient of the simple linear model for long-latency average envelope was significantly smaller than that for short-latency. …”

Table 3_Association between cardiovascular health and markers of liver function: a cross-sectional study from NHANES 2005–2018.docx by Huang Yu (5882174)

“…Weighted quantile sum (WQS) regression and quantile g-computation (QGC) analyses were employed to evaluate the association between CVH and liver function markers.</p>Results<p>Linear regression analysis showed that each 1-point increase in CVH score was significantly associated with decreased levels of liver enzymes [ALT: −0.200 U/L (95% CI: −0.223, −0.176), AST: −0.043 U/L (−0.062, −0.024), GGT: −0.453 U/L (−0.509, −0.397), ALP: −0.310 U/L (−0.340, −0.281)] and increased levels of albumin [0.040 g/dL (0.036, 0.045)] and AST/ALT ratio [0.0056 (0.0051, 0.0061)]. …”

Table 1_Association between cardiovascular health and markers of liver function: a cross-sectional study from NHANES 2005–2018.docx by Huang Yu (5882174)

“…Weighted quantile sum (WQS) regression and quantile g-computation (QGC) analyses were employed to evaluate the association between CVH and liver function markers.</p>Results<p>Linear regression analysis showed that each 1-point increase in CVH score was significantly associated with decreased levels of liver enzymes [ALT: −0.200 U/L (95% CI: −0.223, −0.176), AST: −0.043 U/L (−0.062, −0.024), GGT: −0.453 U/L (−0.509, −0.397), ALP: −0.310 U/L (−0.340, −0.281)] and increased levels of albumin [0.040 g/dL (0.036, 0.045)] and AST/ALT ratio [0.0056 (0.0051, 0.0061)]. …”

Supplementary file 1_Association of antenatal dexamethasone administration timing with outcomes in preterm infants in a low- and middle-income country.docx by Vijay Kalrao (22696397)

“…No other secondary outcomes differed significantly.</p>Conclusion<p>Dexamethasone administration within 24 h before delivery did not reduce mortality but significantly decreased the risk of severe NEC. …”

Data Sheet 1_PANoptosis-related gene clusters and prognostic risk model in clear cell renal cell carcinoma.docx by Qiyue Zhao (12721537)

“…Expression of these hub genes was further validated by RT-qPCR.</p>Results<p>We found that most of the PRGs were upregulated in ccRCC tumors with low mutation rates, and 18 PRGs exhibited a significant correlation with ccRCC patient survival. …”

Data Sheet 1_Systematic analysis of the burden of ischemic stroke attributable to high LDL-C from 1990 to 2021.pdf by Jiahao Tang (12360233)

“…However, the disease burden in high SDI countries remains significant, indicating potential for reduction. Predictions for the next 15 years suggest that while the global disease burden will decrease, there may be an increase among individuals under 55.…”

Image 4_Pronounced impairment of B cell differentiation during bone regeneration in adult immune experienced mice.tiff by Mireille Ngokingha Tchouto (20812811)

“…</p>Results<p>While the B cell proportion in young and non-immune experienced animals did not significantly change from 2 to 5 days post osteotomy in the hematoma, we found a significant decrease of the B cell proportion in the immune experienced mice, which was accompanied by the decreased expression of B cell specific genes, suggesting a specific response in immune experienced animals. …”

Table 1_Pronounced impairment of B cell differentiation during bone regeneration in adult immune experienced mice.xlsx by Mireille Ngokingha Tchouto (20812811)

“…</p>Results<p>While the B cell proportion in young and non-immune experienced animals did not significantly change from 2 to 5 days post osteotomy in the hematoma, we found a significant decrease of the B cell proportion in the immune experienced mice, which was accompanied by the decreased expression of B cell specific genes, suggesting a specific response in immune experienced animals. …”

Image 2_Pronounced impairment of B cell differentiation during bone regeneration in adult immune experienced mice.tiff by Mireille Ngokingha Tchouto (20812811)

“…</p>Results<p>While the B cell proportion in young and non-immune experienced animals did not significantly change from 2 to 5 days post osteotomy in the hematoma, we found a significant decrease of the B cell proportion in the immune experienced mice, which was accompanied by the decreased expression of B cell specific genes, suggesting a specific response in immune experienced animals. …”

Image 1_Pronounced impairment of B cell differentiation during bone regeneration in adult immune experienced mice.tiff by Mireille Ngokingha Tchouto (20812811)

“…</p>Results<p>While the B cell proportion in young and non-immune experienced animals did not significantly change from 2 to 5 days post osteotomy in the hematoma, we found a significant decrease of the B cell proportion in the immune experienced mice, which was accompanied by the decreased expression of B cell specific genes, suggesting a specific response in immune experienced animals. …”

Data Sheet 1_Pronounced impairment of B cell differentiation during bone regeneration in adult immune experienced mice.docx by Mireille Ngokingha Tchouto (20812811)

“…</p>Results<p>While the B cell proportion in young and non-immune experienced animals did not significantly change from 2 to 5 days post osteotomy in the hematoma, we found a significant decrease of the B cell proportion in the immune experienced mice, which was accompanied by the decreased expression of B cell specific genes, suggesting a specific response in immune experienced animals. …”

Image 3_Pronounced impairment of B cell differentiation during bone regeneration in adult immune experienced mice.tiff by Mireille Ngokingha Tchouto (20812811)

“…</p>Results<p>While the B cell proportion in young and non-immune experienced animals did not significantly change from 2 to 5 days post osteotomy in the hematoma, we found a significant decrease of the B cell proportion in the immune experienced mice, which was accompanied by the decreased expression of B cell specific genes, suggesting a specific response in immune experienced animals. …”

Table 1_Respiratory microbiome and metabolome features associate disease severity and the need for doxycycline treatment in children with macrolide-resistant Mycoplasma pneumoniae-... by Wei-Chao Liao (3574649)

“…We identified 15 discriminative amino-acid- and fatty-acid-related metabolites in two groups. …”

Image 5_Pronounced impairment of B cell differentiation during bone regeneration in adult immune experienced mice.tiff by Mireille Ngokingha Tchouto (20812811)

“…</p>Results<p>While the B cell proportion in young and non-immune experienced animals did not significantly change from 2 to 5 days post osteotomy in the hematoma, we found a significant decrease of the B cell proportion in the immune experienced mice, which was accompanied by the decreased expression of B cell specific genes, suggesting a specific response in immune experienced animals. …”

Table 2_Pronounced impairment of B cell differentiation during bone regeneration in adult immune experienced mice.xlsx by Mireille Ngokingha Tchouto (20812811)

“…</p>Results<p>While the B cell proportion in young and non-immune experienced animals did not significantly change from 2 to 5 days post osteotomy in the hematoma, we found a significant decrease of the B cell proportion in the immune experienced mice, which was accompanied by the decreased expression of B cell specific genes, suggesting a specific response in immune experienced animals. …”

Processed Data for “Projecting long-term excess risks of major infectious diseases associated with future extreme weather events in Thailand” by Esther Choo (22590272)

“…</p><p dir="ltr">Historically, extreme heat was associated with an increase in all infectious disease incidences except malaria and leptospirosis. We projected that dengue risk declines in most future climate change scenarios, except SSP245 where extreme heat drives a significant rise in Northern and Central Thailand from 2021–2060. …”

<b>Cannabinoid Receptor 2 Agonism Demonstrates Therapeutic </b><b>Potential in Experimental Models of Relevance to Diabetic Retinopathy</b> by Cayla D. Ontko (21434062)

“…<i>In vivo</i>, both intraocular and systemic HU-308 administration significantly decreased retinal leukostasis in cytokine-induced inflammation and STZ-induced diabetes. …”