Table1_The clinical and genetic aspects of six individuals with GH1 variants and isolated growth hormone deficiency type II.docx by Xiaozhen Huang (5858690)

“…Background<p>Isolated growth hormone deficiency type II (IGHD II) is an autosomal dominant disorder characterized by a GH1 gene variant resulting in a significant reduction in growth hormone (GH) secretion and a subsequent decrease of plasma insulin-like growth factor 1 (IGF-1) levels and eventual growth impairment.…”

Image 2_Volumetric modulated arc therapy total body irradiation improves toxicity outcomes compared to 2D total body irradiation.jpeg by Caressa Hui (19676509)

“…For myeloablative regimen patients, rates of pneumonitis (0% vs. 17%) and nephrotoxicity (9% vs. 36%) were significantly lower with VMAT-TBI versus 2D-TBI (p < 0.01). …”

Image 1_Volumetric modulated arc therapy total body irradiation improves toxicity outcomes compared to 2D total body irradiation.jpeg by Caressa Hui (19676509)

“…For myeloablative regimen patients, rates of pneumonitis (0% vs. 17%) and nephrotoxicity (9% vs. 36%) were significantly lower with VMAT-TBI versus 2D-TBI (p < 0.01). …”

Data Sheet 1_Association of early aspirin use with 90-day mortality in patients with sepsis: an PSM analysis of the MIMIC-IV database.docx by Chunsheng Huang (3222711)

“…K-M curve analysis showed that the 90-day mortality of the aspirin users group was significantly lower than that of the aspirin nonusers group (P < 0.001). …”

Image 1_Global burden trends and future predictions of ischemic heart disease attributable to air pollution in people aged 60 years and older, 1990–2021.jpeg by Yuanqin Zhao (4435384)

“…Overall, the disease burden in the older adult population remains high, with older age groups experiencing the greatest burden and the most significant decrease in ASRs. Men consistently faced a higher burden than women. …”

Data Sheet 1_The CaSBP11 gene functions as a negative regulator in pepper drought stress.doc by Huai-Xia Zhang (8493453)

“…Conversely, overexpression of CaSBP11 in Nicotiana benthamiana decreased drought tolerance, with CaSBP11-overexpressing plants showing reduced ABA sensitivity, lower stomatal aperture and ABA levels, and increased stomatal density and ROS production compared to wild-type plants. …”

<i>Salmonella </i>Typhimurium <i>StiP</i>-mediated upregulation of membrane protein Alx drives complement evasion via CFI-dependent C3b degradation by jin guan (21792620)

“…Typhimurium, among which the <i>StiP</i> deletion strain (263<i>ΔStiP</i>) showed the greatest serum resistance reduction (2.49-fold). We further explored the role of <i>StiP</i> in host blood environment adaptation and found that 263<i>ΔStiP</i> displayed 3.12-fold reduced HeLa cell adhesion, 3.74-fold lower HeLa cell invasion, 1.92-fold decreased intra-macrophage survival, and 50% reduced serum resistance versus wild-type 263 (WT263), collectively indicating that <i>StiP</i> is critical for host blood environment adaptation in invasive <i>S</i>. …”

Supplementary Figures_Fainshtein.pdf by Kfir Sharabi (21415808)

“…Furthermore, we show that depleting <i>Hdac1</i> in mouse primary hepatocytes and liver tissue reduces glucose production, consistent with decreased PGC-1α activity. …”

Data Sheet 1_Meta-analysis of gut microbiota alterations in patients with irritable bowel syndrome.pdf by Xiaxi Li (1512688)

“…</p>Results<p>Significantly lower alpha-diversity indexes were observed in IBS patients by random effects model. …”

Table 1_Predicting the potential distribution of Corylus heterophylla in China under future climate change using an optimized MaxEnt model.docx by Jingyu Wang (292122)

“…The dominant factors influencing the distribution were identified as Bio16 (Precipitation of wettest quarter, 39.5%), Bio9 (Mean temperature of driest quarter, 22.2%), Alt (Altitude, 16.2%), and Bio3 (Isothermality, 7.1%). …”

Supplementary file 1_Wellness-enhancing effects of the canine growth hormone releasing hormone therapy mediated by plasmid and electroporation in healthy old dogs.docx by Min-Ok Ryu (5072594)

“…While mean serum IGF-1 concentrations did not change overall, post-hoc stratification revealed that dogs with low baseline IGF-1 (<90 ng/mL) showed substantial increases, whereas those with high baseline levels tended to decrease. …”

Supplementary file 1_Instability and uncertainty of carbon storage in karst regions under land use change: a case study in Guiyang, China.docx by Heng Zhou (287510)

“…By 2035, projections under natural development, urban expansion, and ecological protection scenarios estimate increases to 147.50 Tg, 147.40 Tg, and 147.82 Tg, respectively. (2) Carbon storage instability increased from 2000 to 2020, while uncertainty is expected to decrease by 2035. Instability was primarily due to transitions of Cropland-Forest, Forest-Cropland, Cropland-Grassland, and Cropland-Impervious, while uncertainties mainly arise from Cropland-Forest, Cropland-Impervious, and Grassland-Impervious transitions. (3) DEM, AI, Distance from national highways, SHDI, and Mean annual precipitation affected instability significantly. (4) Encouraging Shrub-Forest, Shrub-Cropland and Cropland-Forest conversions, and controlling Forest-Cropland, Forest-Shrub, and Cropland-Impervious conversions within the stable intervals of factors, can enhance carbon storage and reduce uncertainty. …”

Table 1_Growth dynamics, reproductive biology, and nutritional profiling of the freshwater mussel Lamellidens marginalis (Lamarck, 1819): implications for wild stock conservation a... by Md. Mostafizur Rahman Mondol (22045478)

“…The results revealed significant variations in the mean biometric parameters across genders and periods. …”

Table 1_Loneliness and mental burden among German medical students during the fading COVID-19 pandemic: a mixed-methods approach.docx by Marvik Leich (20930363)

“…Lower peer connectedness emerged as the sole significant factor associated with loneliness in summer 2022. …”

Data Sheet 1_Susceptibility to and severity of tuberculosis infection in mice depends upon MHC-II-determined level of activation-inhibition balance in CD4 T-cells.pdf by Nadezhda Logunova (831700)

“…<p>Previously we have shown that H2-congenic recombinant mice of the B6.I-9.3 (H2-Ab1^j) strain are significantly more susceptible to tuberculosis (TB) infection compared to their C57BL/6 (B6, H2-A^b) ancestors. …”

Data Sheet 1_Biomechanical mechanisms of multidirectional dynamic compensatory muscle fatigue induced by abnormal cervical curvature: a cross-sectional case-control study based on... by Rui Yang (293531)

“…</p>Results<p>The C2-C7 Cobb angle was significantly lower in the abnormal curvature group compared to the normal group (p < 0.01). …”

Table 1_Biomechanical mechanisms of multidirectional dynamic compensatory muscle fatigue induced by abnormal cervical curvature: a cross-sectional case-control study based on surfa... by Rui Yang (293531)

“…</p>Results<p>The C2-C7 Cobb angle was significantly lower in the abnormal curvature group compared to the normal group (p < 0.01). …”

Telomere-to-telomere genome of <i>Phoebe chekiangensis</i> reveals age-dependent CHG hypomethylation promoting floral transition via MADS-box gene activation by Qinglin Sun (17811556)

“…Their ectopic expression in Arabidopsis significantly accelerated flowering. Whole-genome bisulfite sequencing revealed an age-related decrease in CHG methylation, particularly at the PcMADS19.1 locus. …”

Frequency of short–term outcomes of IVH. by Annette Baine Mwatha (9046241)

“…Logistic regression analysis identified that exposure to antenatal steroids exhibited significantly lower odds of IVH occurrence (AOR 0.075, 95% CI 0.007–0.757). …”

Data Sheet 1_Direct and indirect effects of land use on microbiomes of trap-nesting solitary bee larvae and nests.docx by Birte Peters (12323923)

“…</p>Results<p>As expected, we observed significant shifts in the bacterial composition and diversity of bees and their nests across varying degrees of land use intensity, differing in management types and the availability of flowers. …”