Data Sheet 2_Triterpenes in breast cancer: a systematic review of preclinical evidence in rodents.xlsx by Alexandra Prodea (22617710)

“…The toxicity assessment revealed that triterpenes have in general, insignificant or absent toxicity, with only a small number of studies reporting serious side effects such as leukopenia, hepatotoxicity and mortality at specific doses that were reversed in some cases by the use of carriers, which hold the potential to enhance the therapeutic effect of triterpenes while reducing their systemic toxicity.</p>Conclusion<p>We concluded that the current in vivo evidence does not support the clinical translation of triterpenes for the treatment of breast cancer due to methodological and clinical heterogeneity as well as the lack of toxicity data in a significant number of studies. …”

Table 1_Impact of the Yangtze River on Sediment source-to-sink processes in estuarine bays: a study of the Oujiang River Estuary, SE China.docx by Xia Guang (21570056)

“…Our findings revealed a dynamic pattern of sediment distribution, with the predominant clay minerals in the surface sediment of the offshore area being illite, followed by kaolinite and chlorite, with a minor smectite content. Notably, we observed a gradual increase in the proportions of illite and smectite from the upstream to the estuary, while kaolinite decreased accordingly. …”

Data Sheet 1_Triterpenes in breast cancer: a systematic review of preclinical evidence in rodents.pdf by Alexandra Prodea (22617710)

“…The toxicity assessment revealed that triterpenes have in general, insignificant or absent toxicity, with only a small number of studies reporting serious side effects such as leukopenia, hepatotoxicity and mortality at specific doses that were reversed in some cases by the use of carriers, which hold the potential to enhance the therapeutic effect of triterpenes while reducing their systemic toxicity.</p>Conclusion<p>We concluded that the current in vivo evidence does not support the clinical translation of triterpenes for the treatment of breast cancer due to methodological and clinical heterogeneity as well as the lack of toxicity data in a significant number of studies. …”

Data Sheet 1_Impact of a structured food sequence and mobile health monitoring on gestational diabetes outcomes: a clinical trial.pdf by Ria Murugesan (21795620)

“…A p-value <0.05 was considered statistically significant.</p>Results<p>The intervention group showed significant reductions in 1-h and 2-h postprandial blood glucose levels (−8.41 mg/dL and −7.56 mg/dL respectively, both p < 0.001), decreased LDL cholesterol (−7.33 mg/dL, p < 0.001), increased HDL cholesterol (+6.15 mg/dL, p < 0.001), and improved hemoglobin levels. …”

Data Sheet 1_Unveiling frailty: comprehensive and sex-specific characterization in prematurely aging PolgA mice.pdf by Dilara Yılmaz (19710658)

“…While these approaches have been applied to aging mice, their effectiveness in prematurely aging mouse models such as PolgA^D257A/D257A (PolgA) has not been completely explored. We demonstrated that frailty became evident in PolgA mice around 40 weeks, validated through body weight loss, reduced walking speed, decreased physical activity, and weaker grip strength. …”

Water bridges by Raman Jangra (19231711)

“…To delineate the structural role of water molecules in shaping the interactions between RNA and proteins, we comprehensively analyzed a dataset of 329 high-resolution crystal structures of RNA–protein complexes to identify water-mediated hydrogen-bonded contacts at the RNA–protein interface. …”

Data Sheet 1_Serum levels of per- and polyfluoroalkylated substances and methylation of DNA from peripheral blood.pdf by Hanane Omichessan (4991552)

“…Serum levels of PFOS and PFOA were measured by liquid chromatography coupled to tandem mass spectrometry.</p>Results<p>We found 64 CpG sites with significant hypomethylation or hypermethylation associated with increased levels of PFOA or PFOS (p-value_Bonferroni < 0.05). …”

Spatial variation and clgassification of anthropogenic soils formed by long-term “<i>Dorotsuke”</i> soil-dressing in Andosols of the Omiya Upland along the Arakawa River, Japan by Shokichi Wakabayashi (3872428)

“…The two anthropogenic horizons exceeded 50 cm in thickness with different soil textures, while one of the other two showed significant mixing with Andosol. The profiles exhibited a vertical attenuation of andic characteristics, including increased bulk density, decreased short-range-order mineral content, and reduced phosphate retention, from the buried Andosol up to the topsoil. …”

Algorithms for designing continuous curricula A: Decision tree showing the continuous version of ADP which includes actions that “grow” and “shrink” the increments between continuo... by William L. Tong (22238845)

“…<p>See the text for more details of the task in the continuous setting. B: ADP significantly outperforms INC when the task is difficult (low <i>ε</i>). …”

Data Sheet 1_Safety assessment of tolvaptan: real-world adverse event analysis using the FAERS database.docx by Peiyang Cao (10808613)

“…Notably, strong ADE signals were detected for decreased urine osmolality [n = 5, ROR 149.74, PRR 149.7, IC (Information Component) 7.13, EBGM (Empirical Bayes Geometric Mean) 139.79], osmotic demyelination syndrome (n = 38, ROR 128.47, PRR 128.25, IC 6.92, EBGM 120.91), and pulmonary-related tumors such as bronchial metastatic carcinoma, bronchial carcinoma, metastatic small cell lung carcinoma, and small cell lung carcinoma. …”

Data Sheet 1_Spatial–temporal evolution and associated factors of older adult care institutions in Shanghai.xlsx by Xingxing Yin (7919447)

“…The distribution of older adult care institutions and the aging population shows a positive trend, with the matching degree constantly increasing. The mean deviation index (M) decreased from 0.015 in 2005 to 0.011 in 2020. …”

Table 1_Effects of singing on vascular health in older adults with coronary artery disease: a randomized, crossover trial.docx by Mehri Bagherimohamadipour (21189317)

“…</p>Results<p>Sixty-five subjects (mean age 67.7 ± 0.8 years, 40% female) completed the study. …”

TRIM16 mediates secretory autophagy in head and neck cancer-associated fibroblasts by Thuc Ly (12832686)

“…Using both a literature based, and an unbiased approach, we studied the molecular machinery involved in autophagosome trafficking in CAFs. …”

Table 1_Altered Th17/Treg balance and therapeutic targeting of RORγ in primary focal hyperhidrosis.docx by Min Lin (17652)

“…Background<p>Primary focal hyperhidrosis (PFH) significantly impacts patients’ physical and mental health, yet its underlying mechanisms remain unclear.…”

DataSheet1_IVIG response in pediatric acute-onset neuropsychiatric syndrome correlates with reduction in pro-inflammatory monocytes and neuropsychiatric measures.docx by Isaac Melamed (6291590)

“…</p>Results<p>All ten patients included in the study were male, White, with mean age 12.4 years (range 6–16). Statistically significant improvements following IVIG treatment were demonstrated in all psychometric assessments and parent questionnaires including CY-BOCS (obsessive compulsive scale), YGTSS (tic scale) and a parent PANS rating scale (for all scales p<0.001). …”

Supplementary file 1_Efficacy and safety of the commercial Chinese polyherbal preparation Liu Shen Wan as an adjunctive treatment for herpes zoster and postherpetic neuralgia: a sy... by Yajing Li (1394572)

“…Meta-analysis demonstrated that LSW plus conventional treatment significantly outperformed conventional treatment alone in shortening vesicle cessation time [MD = −1.44, 95% CI (−1.66, −0.93), p < 0.00001, I² = 70%], accelerating scab formation (MD = −1.72, 95% CI (−2.09, −1.35), p < 0.00001, I² = 38%), reducing scab shedding time (MD = −2.22, 95% CI (−3.64, −0.80), p = 0.002, I² = 36%), decreasing time to pain resolution (MD = −2.46, 95% CI (−3.52, −1.39), p < 0.00001, I² = 0%), and shortening pain persistence duration (MD = −1.97, 95% CI (−2.49, −1.46), p < 0.00001, I² = 86%). …”

Supplementary file 2_Efficacy and safety of the commercial Chinese polyherbal preparation Liu Shen Wan as an adjunctive treatment for herpes zoster and postherpetic neuralgia: a sy... by Yajing Li (1394572)

“…Meta-analysis demonstrated that LSW plus conventional treatment significantly outperformed conventional treatment alone in shortening vesicle cessation time [MD = −1.44, 95% CI (−1.66, −0.93), p < 0.00001, I² = 70%], accelerating scab formation (MD = −1.72, 95% CI (−2.09, −1.35), p < 0.00001, I² = 38%), reducing scab shedding time (MD = −2.22, 95% CI (−3.64, −0.80), p = 0.002, I² = 36%), decreasing time to pain resolution (MD = −2.46, 95% CI (−3.52, −1.39), p < 0.00001, I² = 0%), and shortening pain persistence duration (MD = −1.97, 95% CI (−2.49, −1.46), p < 0.00001, I² = 86%). …”

Data Sheet 1_Efficacy and safety of the commercial Chinese polyherbal preparation Liu Shen Wan as an adjunctive treatment for herpes zoster and postherpetic neuralgia: a systematic... by Yajing Li (1394572)

“…Meta-analysis demonstrated that LSW plus conventional treatment significantly outperformed conventional treatment alone in shortening vesicle cessation time [MD = −1.44, 95% CI (−1.66, −0.93), p < 0.00001, I² = 70%], accelerating scab formation (MD = −1.72, 95% CI (−2.09, −1.35), p < 0.00001, I² = 38%), reducing scab shedding time (MD = −2.22, 95% CI (−3.64, −0.80), p = 0.002, I² = 36%), decreasing time to pain resolution (MD = −2.46, 95% CI (−3.52, −1.39), p < 0.00001, I² = 0%), and shortening pain persistence duration (MD = −1.97, 95% CI (−2.49, −1.46), p < 0.00001, I² = 86%). …”

Thymoquinone loaded nanoemulgel in streptozotocin induced diabetic wound by Urati Anuradha (20306190)

“…</p> <p>In diabetic wound animal model nanoemulgel showed significant decreased levels of TNF-α, IL-6, MMP-9 and IL-1β. …”

Table 1_Has carbon finance been able to promote clean energy development? — a low-carbon technology innovation perspective.xlsx by Rui Cui (622759)

“…It is found that carbon finance significantly promotes clean energy development, but this contribution decreases with the intervention of low-carbon technology innovation. …”